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Autor:
Sander Kersten
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100150-(2021)
Journal of Lipid Research, 62
Journal of Lipid Research 62 (2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100150-(2021)
Journal of Lipid Research, 62
Journal of Lipid Research 62 (2021)
Triglycerides are carried in the bloodstream as the components of very low-density lipoproteins and chylomicrons. These circulating triglycerides are primarily hydrolyzed in muscle and adipose tissue by the enzyme lipoprotein lipase (LPL). The activi
Autor:
Nabil G. Seidah
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100130-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100130-(2021)
In 2003 the sequences of mammalian PCSK9 were reported. Radiolabeling pulse-chase analyses demonstrated that PCSK9 was synthesized as a zymogen (proPCSK9) that undergoes autocatalytic cleavage in the endoplasmic reticulum. Distinct from the other pro
Autor:
Yasuhiro Takenouchi, Hironobu Ishimaru, Keisuke Kitakaze, Kazuhito Tsuboi, Maho Tsuda, Yasuo Okamoto
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100141-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100141-(2021)
Lysophosphatidic acid (LPA) is a lipid mediator that regulates various processes, including cell migration and cancer progression. Autotaxin (ATX) is a lysophospholipase D-type exoenzyme that produces extracellular LPA. In contrast, glycerophosphodie
Autor:
Aaron J. Donner, Rosanne M. Crooke, Adam E. Mullick, Richard G. Lee, Mingxia Liu, Thomas A. Bell
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100101-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100101-(2021)
Supported by an abundance of experimental and genetic evidence, angiopoietin-like protein 3 (ANGPTL3) has emerged as a promising therapeutic target for cardiovascular disease. ANGPTL3 is primarily produced by the liver and is a potent modulator of pl
Autor:
Hiroyuki Sugimoto, Yasuhiro Horibata
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100100-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100100-(2021)
Choline phospholipids (PLs) such as phosphatidylcholine (PC) and 1-alkyl-2-acyl-sn-glycerophosphocholine are important components for cell membranes and also serve as a source of several lipid mediators. These lipids are biosynthesized in mammals in
Autor:
Adam Alexander T. Smith, Man K.S. Lee, Michelle Cinel, Bronwyn A. Kingwell, Sudip Paul, Paul J. Nestel, Kevin Culham, Natalie A. Mellett, Kaushala S. Jayawardana, Kevin A. Gunawan, Peter J. Meikle, Jacqueline M. Weir, Graeme I. Lancaster, Andrew J. Murphy
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100092-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100092-(2021)
Plasmalogens are membrane glycerophospholipids with diverse biological functions. Reduced plasmalogen levels have been observed in metabolic diseases; hence, increasing their levels might be beneficial in ameliorating these conditions. Shark liver oi
Publikováno v:
Casteleijn, M G, Parkkila, P, Viitala, T & Koivuniemi, A 2018, ' Interaction of lecithin : Cholesterol acyltransferase with lipid surfaces and apolipoprotein A-I-derived peptides [S] ', Journal of Lipid Research, vol. 59, no. 4, pp. 670-683 . https://doi.org/10.1194/jlr.M082685
Journal of Lipid Research, Vol 59, Iss 4, Pp 670-683 (2018)
Journal of Lipid Research
Journal of Lipid Research, Vol 59, Iss 4, Pp 670-683 (2018)
Journal of Lipid Research
LCAT is an enzyme responsible for the formation of cholesteryl esters from unesterified cholesterol (UC) and phospholipid (PL) molecules in HDL particles. However, it is poorly understood how LCAT interacts with lipoproteins and how apoA-I activates
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 3, Pp 524-530 (2014)
X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by impaired degradation of very long-chain fatty acids (VLCFAs) due to mutations in the ABCD1 gene responsible for VLCFA transport into peroxisomes. Lorenzo's oil, a 4: 1 mixture
Publikováno v:
Robciuc, A, Hyötyläinen, T, Jauhiainen, M & Holopainen, J M 2012, ' Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2 ', Journal of Lipid Research, vol. 53, no. 11, pp. 2286-2295 . https://doi.org/10.1194/jlr.M026732
Journal of Lipid Research, Vol 53, Iss 11, Pp 2286-2295 (2012)
Journal of Lipid Research, Vol 53, Iss 11, Pp 2286-2295 (2012)
Hyperosmolarity (HO) imposes a remarkable stress on membranes, especially in tissues in direct contact with the external environment. Our efforts were focused on revealing stress-induced lipid changes that precede the inflammatory cytokine response i
Autor:
Alma M. Astudillo, Luis Gil-de-Gómez, Jesús Balsinde, Julio M. Rubio, Gema Perez-Chacon, Carlos Guijas, María A. Balboa
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Journal of Lipid Research, Vol 53, Iss 11, Pp 2343-2354 (2012)
instname
Journal of Lipid Research, Vol 53, Iss 11, Pp 2343-2354 (2012)
Resumen del trabajo presentado al Fourth European Workshop on Lipid Mediators (Young session) celebrado en Paris (Francia) del 27 al 28 de septiembre de 2012.
Exposure of human peripheral blood monocytes to free arachidonic acid (AA) results in
Exposure of human peripheral blood monocytes to free arachidonic acid (AA) results in