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Autor:
Riping, Xiao, Kawai, Lei, Hioha, Kuok, Wende, Deng, Yuxin, Zhuang, Yanqing, Tang, Zhengyang, Guo, Hongyan, Qin, Li-Ping, Bai, Ting, Li
Publikováno v:
Journal of Leukocyte Biology. 112:835-843
Primary bile acids (BAs), products of cholesterol metabolism and clearance, are synthesized in the liver and released into the intestine to facilitate the digestion and absorption of lipids. BAs are further converted by gut commensal bacteria into se
Autor:
Andrew P. Hart, Terri M. Laufer
Publikováno v:
Journal of Leukocyte Biology. 111:173-195
T follicular helper (Tfh) cells are a critical component of adaptive immunity and assist in optimal Ab-mediated defense. Multiple effector functions of Tfh support germinal center B cell survival, Ab class switching, and plasma cell maturation. In th
Autor:
Manoj Kumar Barthwal, Kumaravelu Jagavelu, Sachin Kumar, Rajeshwar Nath Srivastava, Samreen Sadaf, Ashok Kumar Agrahari, Abhishek Singh, Madhu Dikshit, Sheela Nagarkoti, Deepika Awasthi
Publikováno v:
Journal of leukocyte biology. 106(2)
Neutrophils play important role in immunity and inflammation through diverse mechanisms. Reports from this lab and others have demonstrated involvement of NO in neutrophil adhesion, chemotaxis, bacterial killing, reactive oxygen species generation, n
Autor:
Loren D. Erickson, Kelly M. Cox
Publikováno v:
Journal of Leukocyte Biology. 101:1-3
Follicular helper T cells (Tfh) support high-affinity Ab production by germinal center B cells through both membrane interactions and secretion of IL-4 and -21, two major cytokines implicated in B-cell survival and Ab class switch. Tfh-2 cells recent
Publikováno v:
Journal of leukocyte biology. 100(4)
Bromodomain protein 4 (BRD4) is a transcriptional and epigenetic regulator that plays a pivotal role in cancer and inflammatory diseases. BRD4 binds and stays associated with chromatin during mitosis, bookmarking early G1 genes and reactivating trans
Autor:
Hyun-Bae Jie, Hyeong-Woo Lee, Tong-Soo Kim, Paul L. Bollyky, Brian S. Wilson, David A. Sarracino
Publikováno v:
Journal of leukocyte biology. 101(4)
In this study, we used the culture supernatant of iNKT cells to identify human myeloid DC maturation factors produced by human CD4+ iNKT cells. S100A8 had a strong maturation effect. Notably, the recombinant S100A8 protein displayed properties of DC
Autor:
Hubert Hackl, Rotraud Wieser, Irene Herbacek, Anna Karger, Torsten A. Konrad, Ilse Schwarzinger
Publikováno v:
Journal of Leukocyte Biology
EVI1, a gene involved in myelodysplastic syndromes, causes growth arrest and cell death in U937 cells. The oncogene EVI1 has been implicated in the etiology of AML and MDS. Although AML cells are characterized by accelerated proliferation and differe
Autor:
Antonio Campos-Caro, José A. Brieva, Francisco Medina, Gema Jiménez-Gómez, Carmen Segundo, Ines Gonzalez-Garcia
Publikováno v:
Journal of Leukocyte Biology. 82:1430-1436
Human plasma cells (PC) are present in cell suspensions obtained from the tonsil by mechanical disaggregation (PC(MECH)). The present study shows that a collagenase treatment of tonsillar debris remaining after mechanical disaggregation yielded simil
Autor:
Ulrike Kostezka, Frank Leithäuser, Facundo D. Batista, Sandra Prokosch, Georg Pougialis, Alexandra Klevenz, Bernd Arnold, Angelo Castello, Anna Tafuri, Sabine Schmitt, Günter Küblbeck, Kun-Hui Lu, Torsten Mattfeldt, Selina Jessica Keppler, Tony Pawson
Publikováno v:
Journal of leukocyte biology. 98(3)
Understanding the molecular mechanisms regulating T cell reactivity is required for successful reprogramming of immune responses in medical conditions, characterized by dysfunctions of the immune system. Nck proteins are cytoplasmic adaptors mediatin
Publikováno v:
Journal of Leukocyte Biology. 79:388-396
Positive transcription elongation factor b (P-TEFb) is an RNA polymerase II elongation factor which exists as multiple complexes in human cells. These complexes contain cyclin-dependent kinase 9 as the catalytic subunit and different cyclin subunits