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Publikováno v:
Journal of Leukocyte Biology. 111:391-400
Neutrophil extracellular traps (NETs)-mediated tissue damage is a hallmark in abdominal sepsis. Under certain conditions, microRNAs (miRs) can regulate protein expression and cellular functions. The aim of this study was to investigate the role of mi
Autor:
Daniel Prantner, Stefanie N. Vogel, David Spiegel, Katharina Richard, Shreeram C. Nallar, Kim D. Collins
Publikováno v:
J Leukoc Biol
The highly reactive compound methylglyoxal (MG) can cause direct damage to cells and tissues by reacting with cellular macromolecules. MG has been identified as a biomarker associated with increased sepsis-induced mortality. Patients undergoing septi
Autor:
John M. Craig, Ifeanyi U. Anidi, Alan L. Scott, Amy K. Poupore, Nathachit Limjunyawong, Wayne Mitzner, H. A. Daniel Lagassé
Publikováno v:
Journal of Leukocyte Biology. 99:659-671
Pulmonary complications occur in a significant percentage of adults and children during the course of severe malaria. The cellular and molecular innate immune mechanisms that limit the extent of pulmonary inflammation and preserve lung function durin
Autor:
Pankaj Sharma, Mrigank Srivastava, Aditi Sharma, Achchhe Lal Vishwakarma, Promod Kumar Agnihotri, Sharad Sharma
Publikováno v:
Journal of Leukocyte Biology. 99:619-628
Eosinophils play a central role in the pathogenesis of tropical pulmonary eosinophilia, a rare, but fatal, manifestation of filariasis. However, no exhaustive study has been done to identify the genes and proteins of eosinophils involved in the patho
Publikováno v:
Journal of Leukocyte Biology. 83:288-295
Endotoxemia is a life-threatening, inflammatory condition that involves multiple organ injury and dysfunction. Preprotachykinin-A (PPT-A) gene products, substance P (SP), and neurokinin-A have been shown to play an important role in neurogenic inflam
Publikováno v:
Journal of Leukocyte Biology. 82:449-456
Fibrocytes were first described over a decade ago as a population of cells in circulation with fibroblast-like properties, which were involved in tissue repair. Since that time, we have learned a significant amount about these bone marrow-derived cel
Autor:
Irshad H. Chaudry, Mashkoor A. Choudhry, William J. Hubbard, Frank Hildebrand, Bjoern M. Thobe, Hans-Christoph Pape
Publikováno v:
Journal of Leukocyte Biology. 80:759-765
We hypothesized that administration of androgen receptors antagonist flutamide following trauma-hemorrhage (T-H) in metestrus females will maintain immune function and reduce remote organ damage under those conditions. Female B57BL/J6 mice (metestrus
Autor:
Cuzzocrea, Salvatore, Mazzon, E, DI PAOLA, R, Peli, A, Bonato, A, Britti, D, Genovese, Tiziana, Muia, C, Crisafulli, Concetta, Caputi, Achille, DI PAOLA, Rosanna
Publikováno v:
Journal of Leukocyte Biology. 79:999-1010
The peroxisome proliferator-activated receptor-α (PPAR- α) is a member of the nuclear receptor superfamily of ligand-dependent transcription factors related to retinoid, steroid, and thyroid hormone receptors. The aim of the present study was to ev
Autor:
Mary Jane Thomassen, Tracey L. Bonfield, Mani S. Kavuru, Carol Farver, Carmen M. Swaisgood, Barbara P. Barna
Publikováno v:
Journal of Leukocyte Biology. 79:133-139
Pulmonary alveolar proteinosis (PAP) is an anti-granulocyte macrophage-colony stimulating factor (GM-CSF) autoimmune disease resulting in the accumulation of phospholipids in the alveoli. GM-CSF knockout (KO) mice exhibit a strikingly similar lung pa
Autor:
Paul S. Foster, Joerg Mattes, Klaus I. Matthaei, Nicole Newcombe, Lindsay A. Dent, Nancy A. Lee, Ljubov Simson, James J. Lee, Aulikki Koskinen, Kristopher Clark
Publikováno v:
Journal of Leukocyte Biology, 75, 6, pp. 1001-9
Journal of Leukocyte Biology, 75, 1001-9
Journal of Leukocyte Biology, 75, 1001-9
Eosinophil degranulation is thought to play a pivotal role in the pathogenesis of allergic disorders. Although mouse models of allergic disorders have been used extensively to identify the contribution of eosinophils to disease, ultrastructural evide