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Autor:
Christoph Jacoby, Sebastian Temme, Jürgen Schrader, Florian Bönner, Ulrich Flögel, Nadine Borg, Zhaoping Ding
Publikováno v:
Journal of Leukocyte Biology. 95:689-697
Inflammation results in the recruitment of neutrophils and monocytes, which is crucial for the healing process. In the present study, we used 19F MRI to monitor in vivo the infiltration of neutrophils and monocytes from the onset of inflammation to t
Autor:
Ralph Kettritz, Adrian Schreiber
Publikováno v:
Journal of Leukocyte Biology. 94:623-631
Necrotizing, small-vessel vasculitis develops in patients with circulating ANCAs. Neutrophils and monocytes harbor the two major ANCA antigens, PR3 and MPO. A whole body of in vitro experiments implicated ANCA-activated neutrophil effector functions
Autor:
Zizhi Tu, Hongwei Lu, Shuhua Chen, Meidong Liu, Xiaoxia Zuo, Ke Liu, Nian Wang, Xianzhong Xiao, Kangkai Wang, Guangwen Chen, Mingshi Yang
Publikováno v:
Journal of Leukocyte Biology. 92:851-857
HSF1 alleviated multiple organ damage and PMN infiltration in mice by suppressing the surface expression of PSGL-1 and CD11b on PMNs during endotoxemia. We have reported previously that HSF1 is essential in protection against the lethal systemic infl
Autor:
Margot Brickelmaier, Kevin Gilbride, Aldo Amatucci, Paula S. Hochman, Tatiana Novobrantseva, Alexander Ibraghimov
Publikováno v:
Journal of Leukocyte Biology. 82:124-132
Excessive scarring or fibrosis is a common feature of a wide spectrum of diseases characterized by an exaggerated Th2 response. The TLR/IL-1 receptor (IL-1R)-related protein ST2 is expressed in a membrane-bound form selectively by Th2 cells and was s
Publikováno v:
Journal of Leukocyte Biology. 81:802-808
Recent in vitro studies suggest that calcitonin gene-related peptide (CGRP) inhibits early B cell differentiation; however, there is no evidence in the intact animal for a role for CGRP in B cell development. Here, we show that in vivo treatment of m
Autor:
Ling Chu Chang, Jeanne L. Burton, George W. Smith, Janelle Durrett Tirrell, Trine Toelboell, Patty S.D. Weber, P.M. Saama
Publikováno v:
Journal of Leukocyte Biology. 75:815-827
One anti-inflammatory action of glu- cocorticoids is down-regulation of surface L-selec- tin on circulating neutrophils. However, it is un- clear if this is a result of release of affected bone marrow neutrophils or if the steroid has direct effects
Autor:
Christina Barja-Fidalgo, Marta S. De Freitas, Fernando Q. Cunha, Maria Augusta Arruda, M.C. Plotkowski, Iolanda M. Fierro, Vany Nascimento-DaSilva
Publikováno v:
Journal of Leukocyte Biology. 65:508-514
Intravenous administration of lipopolysaccharide (LPS) to rats increased the production of nitric oxide (NO) metabolites (NOx) by blood polymorphonuclear neutrophils (PMN) in vitro. Both dexamethasone and L-NMMA, added in vitro to neutrophil cultures
Autor:
R. Whiston, Graham R. Wallace, Lucy Howe, John Marshall, Miles Stanford, John Biggerstaff, Adrian Parnaby-Price
Publikováno v:
Journal of Leukocyte Biology. 64:434-440
Leukocyte trafficking from blood into tissue is a fundamental process in immune surveillance and the immune response to stimuli. Experimental autoimmune uveitis (EAU) is an animal model for posterior uveitis and is mediated by T lymphocytes and macro
Publikováno v:
Journal of Leukocyte Biology. 55:574-580
The proliferation of lung epithelial cells is a prominent feature of lung tissue response following silica-induced lung injury and alveolar macrophages are recognized as a major contributing cell to the lung inflammatory processes. In previous studie
Publikováno v:
Journal of Leukocyte Biology. 55:241-247
The effect of recombinant human interleukin-2 (IL-2) on tumor cell cycle kinetics was evaluated in rats bearing the Walker-256 carcinosarcoma. Seven days after implantation, tumor-bearing rats were infused intravenously with IL-2 at a dose of 500 mg/