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Autor:
Eve Hornsby, Hamish W King, Madusha Peiris, Roberto Buccafusca, Wing-Yiu Jason Lee, Elinor S Wing, L Ashley Blackshaw, James O Lindsay, Andrew J Stagg
Publikováno v:
Journal of Leukocyte Biology. 112:365-381
Monocytes are mononuclear phagocytes that can differentiate to a variety of cell fates under the influence of their microenvironment and hardwired commitment. We found that inhibition of TRPM8 in human blood CD14+ monocytes during a critical 3-h wind
Autor:
Fernanda, Scopelliti, Laura, Mercurio, Caterina, Cattani, Valentina, Dimartino, Cristina, Albanesi, Gianfranco, Costanzo, Concetta, Mirisola, Stefania, Madonna, Andrea, Cavani
Publikováno v:
Journal of Leukocyte Biology. 112:383-393
PI3K pathway plays a crucial role in dendritic cells (DCs) functions, as it regulates different cellular processes, such as maturation and cytokines production. However, the specific role of PI3K p110δ isoform in human DCs has not been thoroughly ad
Autor:
Riping, Xiao, Kawai, Lei, Hioha, Kuok, Wende, Deng, Yuxin, Zhuang, Yanqing, Tang, Zhengyang, Guo, Hongyan, Qin, Li-Ping, Bai, Ting, Li
Publikováno v:
Journal of Leukocyte Biology. 112:835-843
Primary bile acids (BAs), products of cholesterol metabolism and clearance, are synthesized in the liver and released into the intestine to facilitate the digestion and absorption of lipids. BAs are further converted by gut commensal bacteria into se
Publikováno v:
Journal of Leukocyte Biology. 111:1185-1197
Macrophages are widely distributed in a variety of tissues, and the different state of macrophages polarization is closely related to the occurrence, development, and prognosis of inflammation, including periodontitis, a chronic inflammatory disease
Autor:
Zheng Wang, Jiao Li, Weiwei Miao, Hongying Chao, Lijun Wen, Jinlan Pan, Zhao Zeng, Yi Xu, Xiaosen Bian, Jun Zhang, Wenzhong Wu, Suning Chen, Li Yao, Zhen Shen
Publikováno v:
Journal of Leukocyte Biology. 111:981-987
ETO2 is a nuclear co-repressor, which plays a critical role in the regulation of the cell cycle, self-renewal capacity, and differentiation of hematopoietic progenitor cells. We identified novel fusion transcripts involving ETO2 and CTCF by RNA-seq i
Autor:
Ziyang Su, Xi Wang, Xulong Zhang, Zihan Wang, Miaoran Xia, Yujie Zhou, Minghang Yu, Xuefeng Huang, Yi Liu, Nianzeng Xing, Bingbing Wang
Publikováno v:
Journal of Leukocyte Biology. 110:1033-1045
NK cells are innate lymphoid cells that play important roles in tumor eradication and viral clearance. We previously found that deletion or inhibition of the histone methyltransferase Ezh2 (enhancer of zeste homolog 2) in hematopoietic stem and proge
Publikováno v:
Journal of Leukocyte Biology. 110:239-255
Follicular regulatory T (Tfr) cells are recently found to be a special subgroup of regulatory T (Treg) cells. Tfr cells play an important role in regulating the germinal center (GC) response, especially modulating follicular helper T (Tfh) cells and
Autor:
Andrew P. Hart, Terri M. Laufer
Publikováno v:
Journal of Leukocyte Biology. 111:173-195
T follicular helper (Tfh) cells are a critical component of adaptive immunity and assist in optimal Ab-mediated defense. Multiple effector functions of Tfh support germinal center B cell survival, Ab class switching, and plasma cell maturation. In th
Publikováno v:
Journal of Leukocyte Biology
Macrophages are key immune cells in the activation and regulation of immune responses. These cells are present in all tissues under homeostatic conditions and in many disease settings. Macrophages can exhibit a wide range of phenotypes depending on l
Autor:
Ramon Caballero, Edana Cassol, Duale Ahmed, Ashok Kumar, Simon Xin Min Dong, Hamza Ali, Angela M. Crawley, Jonathan B. Angel, Salma Iqbal, Niranjala Gajnayaka, Agatha Vranjkovic
Publikováno v:
Journal of Leukocyte Biology. 110:693-710
The inflammatory and anti-inflammatory Mϕs have been implicated in many diseases including rheumatoid arthritis, multiple sclerosis, and leprosy. Recent studies suggest targeting Mϕ function and activation may represent a potential target to treat