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Publikováno v:
Bruckner-Tuderman, L, McGrath, J A, Robinson, E C & Uitto, J 2013, ' Progress in Epidermolysis Bullosa Research : Summary of DEBRA International Research Conference 2012 ', Journal of Investigative Dermatology, vol. 133, no. 9, N/A, pp. 2121-2126 . https://doi.org/10.1038/jid.2013.127
Epidermolysis bullosa (EB), a group of heritable skin fragility disorders, is characterized by blistering, erosions, and chronic ulcers of the skin and mucous membranes, associated with extracutaneous manifestations with considerable morbidity and mo
Autor:
Geertrui Denecker, Barbara Gilbert, Leslie van der Fits, Jean-Pierre Hachem, Filip Van Nieuwerburgh, Bob Asselbergh, Riet De Rycke, Esther Hoste, Peter Vandenabeele, Wim Declercq, Errol P. Prens, Dieter Deforce
Publikováno v:
Journal of Investigative Dermatology, 133(3), 742-750. Nature Publishing Group
Caspase-14 is an important protease in the proper formation of a fully functional skin barrier. Newborn mice that are deficient in caspase-14 exhibit increased transepidermal water loss and are highly sensitive to UVB-induced photodamage. Decreased c