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Autor:
Kevin Sondenheimer, M. Majora, Jean Krutmann, Sonja Faßbender, Jennifer Schindler, Thomas Haarmann-Stemmann, Friederike V. Opitz, Marius Pollet, Heike Weighardt
Publikováno v:
Journal of Investigative Dermatology. 142:1183-1193
The transcription factor Hypoxia-Inducible Factor-1alpha (HIF-1a) regulates cellular metabolism under hypoxia but also immune responses and UVB-induced skin reactions. In keratinocytes, HIF-1a is an environmental sensor orchestrating the adaptation t
Autor:
Sophia Derdak, Veronika Mlitz, Karin Brigit Holthaus, Florian Ehrlich, Michael Mildner, Leopold Eckhart, Julia Lachner, Erwin Tschachler, Tanja Wagner
Publikováno v:
Journal of Investigative Dermatology. 141:2829-2837
The function of the skin as a barrier against a dry environment evolved in a common ancestor of terrestrial vertebrates such as mammals and birds. However, it is unknown which elements of the genetic program of skin barrier formation are evolutionari
Publikováno v:
Journal of Investigative Dermatology. 141:2679-2689
Opsin-3 (OPN3) is a potential key regulator of human melanocyte melanogenesis. How OPN3-mediated regulation of melanocyte melanogenesis is triggered is largely unclear. TGFβ can inhibit the growth of human melanocytes and reduce melanin synthesis in
Publikováno v:
Journal of Investigative Dermatology. 141:563-574
T helper cells are crucial for psoriasis pathogenesis. Communication between T cells and psoriatic keratinocytes (KCs) helps drive the Th1 and Th17 response, but the underlying mechanism is not well-understood. Small extracellular vesicles (sEVs) are
Publikováno v:
Journal of Investigative Dermatology. 140:2496-2504
FBPs are components of the SCF protein E3 ubiquitin ligase and can specifically bind to substrates and thereby regulate multiple tumor behaviors. However, the role of FBPs, FBXO25 in particular, in cutaneous squamous cell carcinoma (cSCC) has not bee
Publikováno v:
Journal of Investigative Dermatology. 140:1691-1697
Human skin acts as a barrier to protect our bodies from UV rays and external pathogens and to prevent water loss. Phenotypes of aging, or natural aging due to chronic damage, include wrinkles and the reduction of skin thickness that occur because of
Autor:
Michael S. Roberts, Isha N. Haridass, Jeffrey E. Grice, Heather A. E. Benson, Yousuf H. Mohammed
Publikováno v:
Journal of Investigative Dermatology. 140:1656-1659
The regular use of sunscreen products protects against sunburn, photo-aging, and skin cancer (Waldman and Grant-Kels, 2019). A recent Australasian Sunscreen Summit recommended that sunscreens should be applied daily when the UV index is expected to b
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Autor:
Guy Serre, Marie Reynier, Alain Moga, Corinne Leprince, Sophie Allart, Dominique Goudounèche, Michel Simon
Publikováno v:
Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
Journal of Investigative Dermatology, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
Journal of Investigative Dermatology, Nature Publishing Group, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
Journal of Investigative Dermatology, 2019, 139 (7), pp.1430-1438. ⟨10.1016/j.jid.2018.12.021⟩
International audience; Myosin Vb (Myo5b) is an unconventional myosin involved in the actin-dependent transport and tethering of intracellular organelles. In the epidermis, granular keratinocytes accumulate cytoplasmic lamellar bodies (LBs), secretor
Autor:
Yong Yang, Linghan Hu, Bo Hyun Lee, Dingfang Bu, Zhe Xu, Simon Vu, Zhimiao Lin, Jie Zheng, Huijun Wang, Xu Cao, Samuel T Hwang, Mingyang Lee
Publikováno v:
Journal of Investigative Dermatology. 139:1089-1097
Transient receptor potential (TRP) channels respond to various chemical and physical stimuli by mediating cation influx. The skin expresses abundant TRP channels of different subtypes, which play an essential role in the maintenance of skin functiona