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miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes
Autor:
Xinling Bi, Sergiu-Bogdan Catrina, Changchun Xiao, Ola Rollman, Warangkana Lohcharoenkal, Xiaowei Zheng, Hongmei Peng, Queping Liu, Ning Xu Landén, Dongqing Li, Enikö Sonkoly, Le Qu, Li Zhou, Irène Gallais Sérézal, Aoxue Wang, Jacob Grünler, Xi Li, Mona Ståhle, Pehr Sommar, Tongbin Chu, Qing-Sheng Mi, Andor Pivarcsi, Sofie Eliasson Angelstig
Publikováno v:
Journal of Investigative Dermatology. 141:659-671
Persistent and impaired inflammation impedes tissue healing and is a characteristic of chronic wounds. A better understanding of the mechanisms controlling wound inflammation is needed. In this study, we show that in human wound-edge keratinocytes, t
Autor:
Floris C. Loeff, Teresa Tsakok, Lisanne Dijk, Margreet H. Hart, Michael Duckworth, David Baudry, Alice Russell, Nick Dand, Astrid van Leeuwen, Christopher E.M. Griffiths, Nick J. Reynolds, Jonathan Barker, A. David Burden, Richard B. Warren, Annick de Vries, Karien Bloem, Gerrit Jan Wolbink, Catherine H. Smith, Theo Rispens, Marilyn Benham, David Burden, Ian Evans, Christopher Griffiths, Sagair Hussain, Brian Kirby, Linda Lawson, Kayleigh Mason, Kathleen McElhone, Ruth Murphy, Anthony Ormerod, Caroline Owen, Nick Reynolds, Catherine Smith, Richard Warren, Jonathan N.W.N. Barker, Michael R. Barnes, Paola DiMeglio, Richard Emsley, Andrea Evans, Katherine Payne, Deborah Stocken
Publikováno v:
Journal of investigative dermatology, 140(11), 2129-2137. Nature Publishing Group
Ustekinumab is an effective treatment for psoriasis, but response varies between patients. The formation of anti-drug antibodies (ADAs) may explain part of this variation by reducing the free ustekinumab level. Currently, published analyses of the cl
Publikováno v:
J Invest Dermatol
Loss-of-function mutations in the ABCC6 gene cause pseudoxanthoma elasticum and type 2 generalized arterial calcification of infancy, heritable ectopic mineralization disorders without effective treatment. ABCC6 encodes the putative efflux transporte
Autor:
Dulce Lima Cunha, Verena Moosbrugger-Martinz, Sarah Hedtrich, Guy Yealland, Sari Thomforde, Roswitha Plank, Patrick Graff, Marcelo Calderón, Enrico Miceli, Hans Christian Hennies, Katja Martina Eckl, Robert Gruber
Publikováno v:
Journal of Investigative Dermatology. 139:1191-1195
Autor:
Kristian Reich, Norbert Blödorn-Schlicht, Martina Bresch, Jeremias L K Reich, Thomas Falk, Beyhan Ertas, Stefan Jäckle, Julie Schröder, Nadine Steingrube, Anna Hartjen, Markus Meier
Publikováno v:
Journal of Investigative Dermatology. 139:720-723
Autor:
Sen Yang, Yujun Sheng, Xianfa Tang, Caihong Zhu, Xiaoqun Luo, Wenjun Wang, Yang Li, Fusheng Zhou, Yaohua Zhang, Xuejun Zhang, Xiaodong Zheng, Xianbo Zuo, Shengxiu Liu, Dong-Qing Ye, Sheng-an Chen, Gang Chen, Qian Wenjun, Fanping Yang, Zhengwei Zhu, Hui Cheng, Huayang Tang, Jinping Gao, Liangdan Sun, Zaixing Wang, Qinyuan Zhu
Publikováno v:
Journal of Investigative Dermatology. 138:2307-2314
To identify possible additional genetic susceptibility loci for pemphigus vulgaris (PV), we performed a genome-wide association study of 240 PV patients and 1,031 control individuals, and we selected the top single nucleotide polymorphisms for replic
Publikováno v:
Journal of Investigative Dermatology. 138:2480-2483
Autor:
Nihal Kaplan, Robert M. Lavker, Rosa Ventrella, Paul Hoover, Spiro Getsios, Bethany E. Perez White
Publikováno v:
Journal of Investigative Dermatology. 138:2133-2143
EphA2 receptor tyrosine kinase is activated by ephrin-A1 ligand, which harbors a glycosylphosphatidylinositol anchor that enhances lipid raft localization. Although EphA2 and ephrin-A1 modulate keratinocyte migration and differentiation, the ability
Autor:
Ying Luo, Qi-long Chen, Shuang-yi Yin, Jian-kun Song, Jing-Si Jiang, Yi Ru, Yue Luo, Wei Li, Yanwei Xiang, Bing Lu, Le Kuai, Bin Li
Publikováno v:
Journal of Investigative Dermatology. 142:220-231.e8
Persistent chronic inflammation and delayed epithelialization lead to stalled healing in diabetic ulcers (DUs). PD-L1 shows anti-inflammatory and proliferative activities in healing defects, whereas its function in DU pathogenesis remains unknown. Lo
Autor:
Donna A. Culton, Michal Pyzik, Richard S. Blumberg, Victoria P. Werth, Russell P. Hall, James S. Graydon, Joyce Okawa, Laurence J. Blumberg, Josef Symon S. Concha
Publikováno v:
Journal of Investigative Dermatology. 141:2858-2865.e4
Pemphigus is a debilitating IgG-mediated autoimmune disease requiring better tolerated, more targeted, and rapid onset therapies. ALXN1830 is a humanized IgG4 antibody that blocks neonatal Fc receptor interactions with IgG. A multicenter, open-label