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Reduced Il17a Expression Distinguishes a Ly6cloMHCIIhi Macrophage Population Promoting Wound Healing
Autor:
Mathieu P Rodero, Christophe Combadière, Samantha Hodgson, Brett G. Hollier, Kiarash Khosrotehrani
Publikováno v:
Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2013, 133 (3), pp.783-792. ⟨10.1038/JID.2012.368⟩
Journal of Investigative Dermatology, 2013, 133 (3), pp.783-792. ⟨10.1038/JID.2012.368⟩
Journal of Investigative Dermatology, Nature Publishing Group, 2013, 133 (3), pp.783-792. ⟨10.1038/JID.2012.368⟩
Journal of Investigative Dermatology, 2013, 133 (3), pp.783-792. ⟨10.1038/JID.2012.368⟩
Macrophages are the main components of inflammation during skin wound healing. They are critical in wound closure and in excessive inflammation, resulting in defective healing observed in chronic wounds. Given the heterogeneity of macrophage phenotyp
Autor:
Mathieu P Rodero, Herlina Y. Handoko, Graeme J. Walker, Geoffrey R. Hill, Blake Ferguson, Glen M. Boyle, Christian R. Engwerda, Kiarash Khosrotehrani, H. Konrad Muller
Publikováno v:
Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2013, 133 (7), pp.1803-1812. ⟨10.1038/JID.2013.9⟩
Journal of Investigative Dermatology, Nature Publishing Group, 2013, 133 (7), pp.1803-1812. ⟨10.1038/JID.2013.9⟩
Intermittent sunburns, particularly in childhood, are the strongest environmental risk factor for malignant melanoma (MM). In mice, a single neonatal UVR exposure induces MM, whereas chronic doses to adult mice do not. Neonatal UVR alters melanocyte