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Publikováno v:
The Journal of investigative dermatology [J Invest Dermatol] 1964 Dec; Vol. 43, pp. 559-64.
Autor:
Alexander R. Berg, Christin G. Hong, Maryia Svirydava, Haiou Li, Philip M. Parel, Elizabeth Florida, Ross O’Hagan, Carla J. Pantoja, Sundus S. Lateef, Paula Anzenberg, Charlotte L. Harrington, Grace Ward, Wunan Zhou, Alexander V. Sorokin, Marcus Y. Chen, Heather L. Teague, Andrew J. Buckler, Martin P. Playford, Joel M. Gelfand, Nehal N. Mehta
Publikováno v:
Journal of Investigative Dermatology. 142:2909-2919
Psoriasis is a systemic inflammatory disease with an increased risk of atherosclerotic events and premature cardiovascular disease. S100A7, A8/A9, and A12 are protein complexes that are produced by activated neutrophils, monocytes, and keratinocytes
Autor:
Charlie Bridgewood, Miriam Wittmann, Tom Macleod, Abdulla Watad, Darren Newton, Kanchan Bhan, Howard Amital, Giovanni Damiani, Sami Giryes, Nicola Luigi Bragazzi, Dennis McGonagle
Publikováno v:
Journal of Investigative Dermatology. 142:2660-2667
Dupilumab, an IL-4/IL-13 receptor blocker, has been linked to emergent seronegative inflammatory arthritis and psoriasis that form part of the spondyloarthropathy spectrum. We systematically investigated patterns of immune disorders, including predom
Publikováno v:
J Invest Dermatol
The use of preclinical animal models of psoriasis has significantly increased over the last three decades, with each model having unique strengths and limitations. Some models translate better to human disease, and many have provided unique insight i
Publikováno v:
J Invest Dermatol
Autoimmunity results from the breaking of immune tolerance, leading to inflammation and pathology. Although well studied in the conventional T-cell field, the role of nonconventional T cells in autoimmunity is less understood. CD1-restricted T cells
Autor:
Thomas S. McCormick, Pushpa Pandiyan
Publikováno v:
Journal of Investigative Dermatology. 142:867-875
This review focuses on the IL-17A family of cytokines produced by T lymphocytes and other immune cells and how they are involved in cutaneous pathogenic responses. It will also discuss cutaneous dysbiosis and FOXP3+ regulatory T cells in the context
Publikováno v:
Journal of Investigative Dermatology. 142:823-833
Dysregulation in the phenotype and function of neutrophils may play important roles in the initiation and perpetuation of autoimmune responses, including conditions affecting the skin. Neutrophils can have local and systemic effects on innate and ada
Autor:
Sebastiaan J. Vastert, Femke van Wijk, Timothy R D J Radstake, Barbara Giovannone, Chiara Angiolilli, Marlot van der Wal, Emmerik F A Leijten, Judith L. Thijs, Jorg van Loosdregt, Cornelis P. J. Bekker, Michel Olde Nordkamp, Ella Eeftink
Publikováno v:
Journal of Investigative Dermatology. 142:402-413
Dermal fibroblasts are strategically positioned underneath the basal epidermis layer to support keratinocyte proliferation and extracellular matrix production. In inflammatory conditions, these fibroblasts produce cytokines and chemokines that promot
Autor:
Mansoor Saqi, Maria Papanikolaou, Jeremias Reich, Konstantina Dimitrakopoulou, Umar Niazi, Chao Kai Hsu, Chrysanthi Ainali, Evangelia Kesidou, Kristian Reich, John A. McGrath, Alexandros Onoufriadis
Publikováno v:
Journal of Investigative Dermatology. 142:489-493
Autor:
Xianying Xing, Bogi Andersen, Alexander A. Merleev, Jiaoling Chen, Lam C. Tsoi, Joseph Kirma, Mrinal K. Sarkar, Chang Zeng, Robert L. Modlin, Shuai Shao, William R. Swindell, Rachael Wasikowski, Olesya Plazyo, Allison C. Billi, Matteo Pellegrini, Feiyang Ma, Johann E. Gudjonsson, Nicole L. Ward, Jingru Sun, Yanyun Jiang, J. Michelle Kahlenberg, Ranjitha Uppala, Stephan Weidinger, Emanual Michael Maverakis, Bethany E. Perez White, Paul W. Harms, Gang Wang, John J. Voorhees
Publikováno v:
J Invest Dermatol
The Journal of investigative dermatology, vol 141, iss 10
The Journal of investigative dermatology, vol 141, iss 10
Many inflammatory skin diseases are characterized by altered epidermal differentiation. Whether this altered differentiation promotes inflammatory responses has been unknown. Here, we show that IRAK2, a member of the signaling complex downstream of I