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Autor:
Kevin Sondenheimer, M. Majora, Jean Krutmann, Sonja Faßbender, Jennifer Schindler, Thomas Haarmann-Stemmann, Friederike V. Opitz, Marius Pollet, Heike Weighardt
Publikováno v:
Journal of Investigative Dermatology. 142:1183-1193
The transcription factor Hypoxia-Inducible Factor-1alpha (HIF-1a) regulates cellular metabolism under hypoxia but also immune responses and UVB-induced skin reactions. In keratinocytes, HIF-1a is an environmental sensor orchestrating the adaptation t
Publikováno v:
Journal of Investigative Dermatology. 142:774-780
Regulatory T cells (Tregs) play a critical role in regulating tissue inflammation. Reduced Treg numbers and/or suppressive function contribute to autoimmune disease. Tregs can adopt the transcriptional programming of T helper (Th) type-1/2/17 cells t
Publikováno v:
J Invest Dermatol
Autoimmunity results from the breaking of immune tolerance, leading to inflammation and pathology. Although well studied in the conventional T-cell field, the role of nonconventional T cells in autoimmunity is less understood. CD1-restricted T cells
Publikováno v:
Journal of Investigative Dermatology. 141:2338-2343
Periostin, an extracellular matrix and matricellular protein, binds to several types of integrins that transduce its signals. Its function in allergic inflammation is the establishment of sustained chronic inflammation through an amplification of T h
Autor:
Xianying Xing, Bogi Andersen, Alexander A. Merleev, Jiaoling Chen, Lam C. Tsoi, Joseph Kirma, Mrinal K. Sarkar, Chang Zeng, Robert L. Modlin, Shuai Shao, William R. Swindell, Rachael Wasikowski, Olesya Plazyo, Allison C. Billi, Matteo Pellegrini, Feiyang Ma, Johann E. Gudjonsson, Nicole L. Ward, Jingru Sun, Yanyun Jiang, J. Michelle Kahlenberg, Ranjitha Uppala, Stephan Weidinger, Emanual Michael Maverakis, Bethany E. Perez White, Paul W. Harms, Gang Wang, John J. Voorhees
Publikováno v:
J Invest Dermatol
The Journal of investigative dermatology, vol 141, iss 10
The Journal of investigative dermatology, vol 141, iss 10
Many inflammatory skin diseases are characterized by altered epidermal differentiation. Whether this altered differentiation promotes inflammatory responses has been unknown. Here, we show that IRAK2, a member of the signaling complex downstream of I
Publikováno v:
Journal of Investigative Dermatology. 141:2775-2777
Dysfunctional autophagy is linked to various diseases, including psoriasis and atopic dermatitis. Recent evidence suggests that exposure of keratinocytes to TNF-α results in impaired autophagy and lysosomal function. The skin of patients with psoria
Autor:
Yiting Lin, Zhenlai Zhu, Hua Meng, Gang Wang, Jiaoling Chen, Shujie An, Hua Bai, Nanxi Sha, Erle Dang, Shuai Shao, Qingyang Li
Publikováno v:
Journal of Investigative Dermatology. 141:787-799
Neutrophil infiltration and papillary vessel dilation are hallmarks of the initiation phase of psoriatic lesions. However, how neutrophils aggravate psoriasis development during transendothelial migration and the interaction between neutrophils and c
Publikováno v:
Journal of Investigative Dermatology. 141:1087-1095
As global life expectancy continues to rise, we are challenged with maintaining health into old age. One strategy is to target the chronic low-level inflammation associated with aging, termed inflammaging. This is characterized by increased levels of
miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes
Autor:
Xinling Bi, Sergiu-Bogdan Catrina, Changchun Xiao, Ola Rollman, Warangkana Lohcharoenkal, Xiaowei Zheng, Hongmei Peng, Queping Liu, Ning Xu Landén, Dongqing Li, Enikö Sonkoly, Le Qu, Li Zhou, Irène Gallais Sérézal, Aoxue Wang, Jacob Grünler, Xi Li, Mona Ståhle, Pehr Sommar, Tongbin Chu, Qing-Sheng Mi, Andor Pivarcsi, Sofie Eliasson Angelstig
Publikováno v:
Journal of Investigative Dermatology. 141:659-671
Persistent and impaired inflammation impedes tissue healing and is a characteristic of chronic wounds. A better understanding of the mechanisms controlling wound inflammation is needed. In this study, we show that in human wound-edge keratinocytes, t
Publikováno v:
Journal of Investigative Dermatology. 141:2325-2327
Aberrant epidermal differentiation is a hallmark of inflammatory skin diseases, including psoriasis and atopic dermatitis. If and how differentiated epidermal cells contribute to inflammatory pathology is unclear. In their new article in the Journal