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Publikováno v:
Journal of Investigative Dermatology. 142:1755-1758
Sezary syndrome (SS) is an aggressive form of cutaneous T-cell lymphoma with a diverse set of mutated genes. Using previously published datasets, we reanalyzed the copy number landscape of SS and detected whole genome amplifications in 20% of all SS
Autor:
Haowu Jiang, Katherine Beattie, Wenqin Luo, Mayank Gautam, Barbara A. Miller, Minghong Ma, Qin Liu, Mary K. MacVittie
Publikováno v:
J Invest Dermatol
Contact dermatitis (CD), including allergic and irritant CD, are common dermatological diseases and are characterized by an erythematous rash and severe itch. In this study, we investigated the function of TRPC3, a canonical transient receptor potent
Publikováno v:
J Invest Dermatol
Autoimmunity results from the breaking of immune tolerance, leading to inflammation and pathology. Although well studied in the conventional T-cell field, the role of nonconventional T cells in autoimmunity is less understood. CD1-restricted T cells
Publikováno v:
Journal of Investigative Dermatology. 142:823-833
Dysregulation in the phenotype and function of neutrophils may play important roles in the initiation and perpetuation of autoimmune responses, including conditions affecting the skin. Neutrophils can have local and systemic effects on innate and ada
Autor:
Xiaowei Liu, Jiqiao Yang, Xiujing He, Guangchao Xu, Jianping Hu, Yu Bao, Jie Xu, Jing Yu, Chune Yu, Jing Jing, Ya Luo, Hubing Shi, Yanna Li, Wenshuang Wu, Rongjie Zhang, Hongying Chen, Xin Yu
Publikováno v:
Journal of Investigative Dermatology. 142:445-458
As a hallmark of cancer, angiogenesis plays a pivotal role in carcinogenesis. However, the correlation between angiogenesis and the evolution of BRAFV600E kinase inhibitor‒acquired resistance is still poorly understood. In this study, we reported t
Publikováno v:
Journal of Investigative Dermatology. 141:2354-2368
Cutaneous squamous cell carcinomas (SCCs) are frequent heterogeneous tumors arising from sun-exposed regions of the skin and characterized by complex pathogenesis. HOPX is a member of the homeodomain-containing superfamily of proteins holding an atyp
Autor:
Mechthild Hatzfeld, Thomas M. Magin
Publikováno v:
Journal of Investigative Dermatology. 142:272-274
Single gene disorders are ideally suited to establish robust genotype‒phenotype correlations and provide excellent opportunities to understand molecular pathomechanisms with relevance to complex disorders. The observation that patients diagnosed wi
Autor:
Yuhree Kim, Samridhi Banskota, Qiuming Yao, Charles B. Epstein, Bradley E. Bernstein, Maryam M. Asgari, Luca Pinello, Robbyn Issner
Publikováno v:
Journal of Investigative Dermatology. 141:1207-1218
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are both derived from epidermal keratinocytes but are phenotypically diverse. To improve the understanding of keratinocyte carcinogenesis, it is critical to understand epigenetic alteration
Autor:
Lauren S. Mohan, Lacey Kruse, Kevin P. White, Katherine Shi, Annette Wagner, Timothy Taxter, Bin Zhang, Yongzhan Zhang, Victor L. Quan, Nike Beaubier, Lihua Zou, Pedram Gerami
Publikováno v:
Journal of Investigative Dermatology. 140:1599-1608
The newest World Health Organization classification of skin tumors suggests the elimination of cases with BRAF and NRAS mutations from the categories of Spitz tumors (ST) and Spitz melanoma (SM). The objective of this study is to better characterize
Publikováno v:
Journal of Investigative Dermatology. 140:2111-2113
Mohamad et al. (2020) describe loss-of-function mutations in SERPINA12 as a cause of diffuse, transgradient palmoplantar keratoderma (PPK). This disorder shares similar clinical features with other PPKs caused by protease overactivity, including eryt