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Autor:
Zenzo Isogai, Seiya Matsui, Yosuke Yagi, Yoshiki Miyachi, Eri Muroga, Susumu Ikehara, Atsushi Utani, Shigehiko Suzuki, Motoko Naitoh
Publikováno v:
Journal of Investigative Dermatology. 133:386-393
The most distinctive feature of keloid is the extreme deposition of extracellular matrix, including collagens and proteoglycans (PGs). The focus of this study was the PG versican, which presumably defines keloid volume because of its ability to retai
Autor:
Martin Hrabé de Angelis, Helmut Fuchs, Jenny Li-Ying Huang, Mugdha Deo, Catherine D. Van Raamsdonk
Publikováno v:
J. Invest. Dermatol. 133, 49-58 (2013)
Mutations in neurofibromin (NF1) cause the dominant genetic disorder neurofibromatosis type 1. Neurofibromatosis is characterized by Schwann cell-based tumors and skin hyperpigmentation, resulting from both haploinsufficiency and loss of heterozygosi