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Autor:
Noëmie Pörtner, Jo Van Damme, Sofie Struyf, Nele Berghmans, Alexandra De Zutter, Mieke Gouwy, Sara Abouelasrar Salama, Lotte Vanbrabant, Mieke De Buck
Publikováno v:
Journal of Interferon & Cytokine Research. 40:195-206
Chronic hepatitis C virus (HCV) infection accounts for a large proportion of hepatic fibrosis and carcinoma cases observed worldwide. Mechanisms involved in HCV-induced hepatic injury have yet to be fully elucidated. Of particular interest is the cap
Autor:
Qi Zhang, Ying Xu, Juncheng Yang, Qunfang Fu, Zhanhui Wang, Kangxian Luo, Guifeng Yang, Hai Liu, Xiaoting Wu, Xuan Huang, Lu Ning
Publikováno v:
Journal of Interferon & Cytokine Research. 39:740-751
Treatment of chronic hepatitis B with pegylated-interferon-α-2a (PegIFNα) in pediatric patients can lead to a higher rate of hepatitis B virus (HBV) surface antigen (HBsAg) loss than in adults. However, the mechanism of underlying immune response i
Autor:
Hongjie Xia, Pei Yong Shi
Publikováno v:
Journal of Interferon & Cytokine Research
The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), warranting urgent study of the molecular mechanisms of SARS-CoV-2 infection and host immune response. Type I interferon (IFN-I
Autor:
Rodolfo Emilio Domínguez, Natacha Mezquia, Lissette del Rosario Lopez, Rafael Venegas, Albadio Pérez, Hubert Blas Rivero, Juan Carlos Rivero, Daniel Gonzalez, Julio Roberto Betancourt, Ricardo Pereda
Publikováno v:
Journal of Interferon & Cytokine Research
A prospective observational study was conducted for assessing the therapeutic efficacy of interferon (IFN)-α2b in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first month after the coronavirus diseas
Autor:
Zaid Mutahar Mohammed Alezzi, Mansour Ali Alamrani, Waleed F. Fathallah, Fouad Othman, Ayman Yosry Abd El Rehim
Publikováno v:
Journal of Interferon & Cytokine Research. 38:38-44
Hepatitis C virus (HCV) infection is increasingly seen as a major public health problem, threat, and concern worldwide. In Yemen about 1.7% of the population is infected with chronic hepatitis C. This study aimed to detect the predictors for response
Publikováno v:
Journal of Interferon & Cytokine Research. 37:342-347
Infection with hepatitis C virus (HCV) remains one of the serious human diseases worldwide, especially in Egypt, which can lead to cirrhosis or hepatocellular carcinoma (HCC). However, the exact molecular mechanism of HCC progress in HCV-infected pat
Autor:
Javier García-Samaniego, Alfonso Cabello, Miguel Górgolas, Antonio Madejón, B. Alvarez, Luz Martín-Carbonero, Norma Rallón, Marcial García, José M. Benito
Publikováno v:
Journal of Interferon & Cytokine Research. 37:278-286
Despite new treatments for hepatitis C virus (HCV) infection, IFNα-based regimens still have clinical relevance in special populations of patients and remain the only therapeutic option for many patients. We sought to elucidate the interplay between
Publikováno v:
Journal of Interferon & Cytokine Research. 37:246-253
ISG15 is a ubiquitin-like type I IFN-stimulated protein of 15 kDa and is one of the most prominently expressed proteins in viral infections. ISG15 is widely known to be involved in a process called ISGylation, where it binds to over 150 targets from
Autor:
M ColstonElizabeth, SrinivasanSubasree, M Wind-RotoloMegan, XuDong, W HruskaMatthew, NarasimhanPremkumar, KishnaniNarendra, ZwirtesRicardo
Publikováno v:
Journal of Interferon & Cytokine Research. 36:644-651
The phase 2b EMERGE study compared the efficacy/safety of peginterferon lambda-1a (Lambda) and peginterferon alfa-2a (Alfa), both with ribavirin (RBV), for treatment of chronic hepatitis C virus (HCV) infection. A key safety finding was a higher freq
Distinct Patterns of Expression of Transcription Factors in Response to Interferonβ and Interferonλ1
Autor:
Voskanian-KordiAlin, SimonyanVahan, A RennLynnsey, C TheisenTerence, MassieTammy, NovattHilary, L RabinRonald, MassieTristan
Publikováno v:
Journal of Interferon & Cytokine Research. 36:589-598
After viral infection, type I and III interferons (IFNs) are coexpressed by respiratory epithelial cells (RECs) and activate the ISGF3 transcription factor (TF) complex to induce expression of a cell-specific set of interferon-stimulated genes (ISGs)