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Autor:
Linnan Zhang, Jianping Ma, Xiaoyang Jin, Liwei Zhang, Mengfan Zhang, Patrick Z. Li, Jingyun Li, Liguo Zhang
Publikováno v:
Journal of Interferon & Cytokine Research. 42:580-589
Type I interferons (IFN-Is) play central roles in regulating immune responses. The role of IFNAR2 in IFN-I signaling is an open question since a previous report showed that IFNβ was still functional in the absence of IFNAR2 in mice. In this study, w
Autor:
Linggai Cao, Lili Zhang, Xiaolian Zhang, Jia Liu, Meng-Ao Jia, Jishun Zhang, Jiemin Liu, Feng Wang
Publikováno v:
Journal of Interferon & Cytokine Research. 42:62-71
Interferons (IFNs) are divided into 3 types (type I, type II, and type III) on the basis of sequence homology and functional properties. Recombinant IFNs have been approved by regulatory agencies in many countries for clinical treatment of hepatitis
Autor:
Qi Zhang, Ying Xu, Juncheng Yang, Qunfang Fu, Zhanhui Wang, Kangxian Luo, Guifeng Yang, Hai Liu, Xiaoting Wu, Xuan Huang, Lu Ning
Publikováno v:
Journal of Interferon & Cytokine Research. 39:740-751
Treatment of chronic hepatitis B with pegylated-interferon-α-2a (PegIFNα) in pediatric patients can lead to a higher rate of hepatitis B virus (HBV) surface antigen (HBsAg) loss than in adults. However, the mechanism of underlying immune response i
Publikováno v:
Journal of Interferon & Cytokine Research. 39:416-420
Population studies indicate women have higher prevalences of depression and anxiety than men. Interferon (IFN) is a biologic agent that can induce or exacerbate depression and/or anxiety. Whether women are more likely to experience these side effects
Autor:
Mohamed Salaheldin, Mohamed F Montasser, Muneer J. Al-Husseini, Fathiya El-Raey, Samy Zaky, Elsayed G Mohammed, Abdelrahman Ibrahim Abushouk, Dina Johar
Publikováno v:
Journal of Interferon & Cytokine Research. 39:85-94
Interferon-alpha (IFN-α)-based therapy is associated with several hematological adverse events in hepatitis C virus (HCV)-infected patients with advanced fibrosis. We performed this study to evaluate the association between Fibrosis-4 (Fib-4) index
Autor:
Hongjie Xia, Pei Yong Shi
Publikováno v:
Journal of Interferon & Cytokine Research
The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), warranting urgent study of the molecular mechanisms of SARS-CoV-2 infection and host immune response. Type I interferon (IFN-I
Autor:
Rodolfo Emilio Domínguez, Natacha Mezquia, Lissette del Rosario Lopez, Rafael Venegas, Albadio Pérez, Hubert Blas Rivero, Juan Carlos Rivero, Daniel Gonzalez, Julio Roberto Betancourt, Ricardo Pereda
Publikováno v:
Journal of Interferon & Cytokine Research
A prospective observational study was conducted for assessing the therapeutic efficacy of interferon (IFN)-α2b in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first month after the coronavirus diseas
Autor:
Dorota Dybowska, Magdalena Tudrujek, A. Staniaszek, Zbigniew Deroń, Ewa Janczewska, Jerzy Jaroszewicz, Beata Dobracka, Iwona Orłowska, Marta Wawrzynowicz-Syczewska, Łukasz Laurans, Krzysztof Simon, Beata Lorenc, Robert Flisiak, Aleksander Garlicki, Olga Tronina, Teresa Belica-Wdowik, Andrzej Horban, Hanna Berak, Waldemar Halota, Dorota Zarębska-Michaluk, Marek Sitko, Małgorzata Pawłowska, Łukasz Socha, Barbara Baka-Ćwierz, Jolanta Białkowska, Anna Piekarska, Agnieszka Czauż-Andrzejuk, Włodzimierz Mazur, Krzysztof Tomasiewicz, Andrzej Gietka
Publikováno v:
Journal of Interferon & Cytokine Research. 38:93-100
The aim of the study is to analyze treatments available for patients infected with genotype (G) 3 hepatitis C virus (HCV) in Poland at the beginning of the interferon (IFN)-free era and evaluate the efficacy and safety of different therapeutic option
Autor:
Zaid Mutahar Mohammed Alezzi, Mansour Ali Alamrani, Waleed F. Fathallah, Fouad Othman, Ayman Yosry Abd El Rehim
Publikováno v:
Journal of Interferon & Cytokine Research. 38:38-44
Hepatitis C virus (HCV) infection is increasingly seen as a major public health problem, threat, and concern worldwide. In Yemen about 1.7% of the population is infected with chronic hepatitis C. This study aimed to detect the predictors for response
Autor:
Rui Zhou, Zongfang Li, Dan Bai, Hong Deng, Zhifang Cai, Fanpu Ji, Wenjun Wang, Yuan Shen, Shengbang Wang, Caini He
Publikováno v:
Journal of Interferon & Cytokine Research. 37:362-368
Although eradication of hepatitis C virus (HCV) decreases the risk of hepatocellular carcinoma (HCC) development, a considerable level of risk remains in cirrhotic patients with advanced liver disease. Yet, data for the effect of serum markers on HCC