Zobrazeno 1 - 10
of 11
pro vyhledávání: '"M. Allen"'
Autor:
Stephanie Jost, Marcus Altfeld, Siddhartha Sharma, Marisol Romero-Tejeda, Michael Sirignano, Todd M. Allen, Christine D. Palmer
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 196(2)
Multiple studies have shown correlates of immune activation with microbial translocation and plasma LPS during HIV infection. It is unclear whether this activation is due to LPS, residual viral replication, or both. Few studies have addressed the eff
Autor:
Brian D. Evavold, Cheng Zhu, Stephen P. Persaud, Jinsung Hong, Paul M. Allen, Stephen Horvath
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 195(8)
We have recently shown that two-dimensional (2D) and force-regulated kinetics of TCR–peptide-bound MHC class I (pMHC-I) interactions predict responses of CD8+ T cells. To test whether these findings are applicable to CD4+ T cells, we analyzed the i
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 193(4)
Thymic selection is designed to ensure TCR reactivity to foreign Ags presented by self-MHC while minimizing reactivity to self-Ags. We hypothesized that the repertoire of T cells with unwanted specificities such as alloreactivity or autoreactivity ar
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 185(5)
Th cell subsets have unique calcium (Ca2+) signals when activated with identical stimuli. The regulation of these Ca2+ signals and their correlation to the biological function of each T cell subset remains unclear. Trpm4 is a Ca2+-activated cation ch
Autor:
Hong Mei Li, Qing Mao, John Sidney, Andrea L. Cox, Dale M. Netski, Drew M. Pardoll, Jurgen Kuball, Stuart C. Ray, Daniel G. Kavanagh, Alessandro Sette, Thomas Kuntzen, Timothy Mosbruger, Alleluiah Rutebemberwa, Todd M. Allen, Matthias Wolfl, Philip D. Greenberg
Publikováno v:
Scopus-Elsevier
Hepatitis C virus (HCV) infection frequently persists despite eliciting substantial virus-specific immune responses. Thus, HCV infection provides a setting in which to investigate mechanisms of immune escape that allow for viral persistence. Viral am
Publikováno v:
ResearcherID
Helper T cell subsets have evolved to respond to different pathogens, and upon activation secrete distinct sets of cytokines. The discovery and identification of Th17 cells, which develop via a unique lineage from Th1 and Th2 cells, have provided new
Autor:
Eric Hailman, Paul M. Allen
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 175(8)
CD4+CD8+ double-positive (DP) thymocytes express a lower level of surface TCR than do mature T cells or single-positive (SP) thymocytes. Regulation of the TCR on DP thymocytes appears to result from intrathymic signaling, as in vitro culture of these
Autor:
Isao Tawara, Takuma Kato, Robert D. Schreiber, Paul M. Allen, Hiroyoshi Nishikawa, Lloyd J. Old, Kagemasa Kuribayashi, Hiroaki Ikeda, Hiroshi Shiku
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 175(7)
Immunization with serological identification of Ags by recombinant expression cloning (SEREX)-defined self-Ags leads to generation/activation of CD4+CD25+ regulatory T cells with suppressive activities and enhanced expression of Foxp3. This is associ
Autor:
Paul M. Allen, Silvia S. Kang
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 174(9)
Although IL-10 acts as an inhibitory cytokine for APC and CD4+ T cell function, its effects on CD8+ T cells are unclear. Additionally, little is known about whether initial priming in the presence of IL-10 can have long-lasting effects and influence
Autor:
Paul M. Allen, Lyse A. Norian
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 173(2)
Aging is associated with a decline in immune function, particularly within the T cell compartment. Because CD8+ T cells are critical mediators of protective immunity against cancer, which arises more frequently with advancing age, it is important to