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Autor:
Stephen M. Ansell, Svetomir N. Markovic, Luis F. Porrata, Ivana N. Micallef, William J. Hogan, David J. Inwards, Patrick B. Johnston
Publikováno v:
Journal of Hematology & Oncology
Background The infused autograft lymphocyte-to-monocyte ratio (A-LMR) is a prognostic factor for survival in B-cell lymphomas post-autologous peripheral hematopoietic stem cell transplantation (APHSCT). Thus, we set out to investigate if the A-LMR is
Autor:
Yong-Mei Zhu, Jing Wu, Chun-Lei Jiang, Shu-Min Xiong, Xiaodong Xi, Yan Sheng, Bing Chen, Qing-lei Kong, Yunxiang Zhang, Junmin Li, Qi Cao, Sai-Juan Chen, Cong Yu, Xiang-Qin Weng
Publikováno v:
Journal of Hematology & Oncology
Background Minimal residual disease detection in the bone marrow is usually performed in patients with acute myeloid leukemia undergoing one course of induction chemotherapy. To optimize the chemotherapy strategies, more practical and sensitive marke
Autor:
Britta Halter, Sabine Hojas, Johannes Andel, Armin Zebisch, Michael Pfeilstöcker, Richard Greil, Heinz Sill, Eva-Maria Autzinger, Sonja Burgstaller, Sigrid Machherndl-Spandl, Konstantin Schlick, Reinhard Stauder, Alois Lang, Wolfgang R. Sperr, Daniela Voskova, Dietmar Geissler, Angelika Pichler, Klaus Geissler, Inga Mandac Rogulj, Michael Girschikofsky, Josef Thaler, Lisa Pleyer
Publikováno v:
Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-16 (2016)
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-16 (2016)
Background The MDS-IWG and NCCN currently endorse both FAB and WHO classifications of MDS and AML, thus allowing patients with 20–30 % bone marrow blasts (AML20–30, formerly MDS-RAEB-t) to be categorised and treated as either MDS or AML. In addit
Autor:
Elvira Dietrich, Lisa Nonnenmacher, Michal Hlavac, Josef Högel, Timo Burster, C. Rainer Wirtz, E. Marion Schneider, Michael K. Georgieff, Haouraa Mostafa, Andrej Pala, M. Andrew Westhoff
Publikováno v:
Journal of Hematology & Oncology
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-14 (2016)
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-14 (2016)
Background Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The current study aimed at the analysis of immunological control in individual patie
Autor:
Joseph D. Khoury, Hagop M. Kantarjian, Rajesh R. Singh, Mark J. Routbort, Keyur P. Patel, Jorge E. Cortes, Rajyalakshmi Luthra, Carlos E. Bueso-Ramos, Sanam Loghavi, L. Jeffrey Medeiros, Liping Zhang, Zhuang Zuo, Francesco C. Stingo, Farhad Ravandi
Publikováno v:
Journal of Hematology & Oncology
De novo acute myeloid leukemia (AML) with concurrent DNMT3A, FLT3 and NPM1 mutations (AML DNMT3A/FLT3/NPM1 ) has been suggested to represent a unique AML subset on the basis of integrative genomic analysis, but the clinical features of such patients
Autor:
Rajyalakshmi Luthra, Jie Peng, Keyur P. Patel, Hagop M. Kantarjian, Rajesh R. Singh, Maitrayee Goswami, Guillermo Garcia-Manero, Guilin Tang, Mark J. Routbort, Sa Wang, L. Jeffrey Medeiros, Ken H. Young, Chi Young Ok
Publikováno v:
Journal of Hematology & Oncology
Background TP53 mutation is more prevalent in therapy-related myeloid neoplasms (t-MN) than their de novo counterparts; however, the pattern of mutations involving TP53 gene in t-MN versus de novo diseases is largely unknown. Methods We collected 108
Autor:
Yun Lian, Yaoyu Chen, Si-Xuan Qian, Jiayu Huang, Yue Xie, Yanru Li, Jianping Mao, Shuai Wang, Jianyong Li, Huihui Zhao, Yu Zhu, Ming Hong
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-13 (2016)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Background Cancer cells show increased glycolysis and take advantage of this metabolic pathway to generate ATP. The TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits aerobic glycolysis and protects tumor cells from intracellular reacti
Autor:
Lee Li-Qun Pu, Weijie Ma, Yanhong Zhang, Hong Li, Garrett M. Frampton, Michael Molmen, Philip J. Stephens, Ken Y. Yoneda, Tianhong Li, Elizabeth H Moore
Publikováno v:
Journal of hematology & oncology, vol 10, iss 1
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-9 (2017)
Journal of Hematology & Oncology
Li, H; Ma, W; Yoneda, KY; Moore, EH; Zhang, Y; Pu, LLQ; et al.(2017). Severe nivolumab-induced pneumonitis preceding durable clinical remission in a patient with refractory, metastatic lung squamous cell cancer: a case report. Journal of Hematology and Oncology, 10(1). doi: 10.1186/s13045-017-0433-z. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9tk43241
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-9 (2017)
Journal of Hematology & Oncology
Li, H; Ma, W; Yoneda, KY; Moore, EH; Zhang, Y; Pu, LLQ; et al.(2017). Severe nivolumab-induced pneumonitis preceding durable clinical remission in a patient with refractory, metastatic lung squamous cell cancer: a case report. Journal of Hematology and Oncology, 10(1). doi: 10.1186/s13045-017-0433-z. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/9tk43241
© 2017 The Author(s). Background: Programmed cell death 1 (PD-1) and its ligand 1 (PD-L1) inhibitors have quickly become standard of care for patients with advanced non-small cell lung cancer and increasing numbers of other cancer types. In this rep
Autor:
Tie-Qiang Liu, Yao Wang, Weidong Han, Chang-Lin Yu, Bing-Xia Li, Zheng Dong, Jian-Hui Qiao, Yu-Jing Sun, Mingxing Feng, Hong-Li Zuo, Yelei Guo, Qi-Yun Sun, Mei Guo, Jun Yang, Zechuan Zhang, Yajing Zhang, Zhiqing Liu, Hui-Sheng Ai, Ya-Jing Huang, Bo Cai, Yi Wang, Kai-Xun Hu, Hanren Dai, Bo Yao
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-6 (2016)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Background Elderly patients with relapsed and refractory acute lymphoblastic leukemia (ALL) have poor prognosis. Autologous CD19 chimeric antigen receptor-modified T (CAR-T) cells have potentials to cure patients with B cell ALL; however, safety and
Autor:
Yue Zhang, Zhijian Xiao, Tiejun Qin, Robert Peter Gale, Zefeng Xu, Qian Jiang, Peihong Zhang, Yajuan Cui, Bing Li
Publikováno v:
Journal of Hematology & Oncology
The WHO 2008 definition of chronic neutrophilic leukemia (CNL) is based on clinical and laboratory parameters but not on molecular abnormalities. Mutations in CSF3R, SETBP1 and CALR are reported in patients with chronic neutrophilic leukemia (CNL). H