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Autor:
Yuki Hayata, Motoyuki Otsuka, Yasuo Tanaka, Masaya Sato, Hayato Nakagawa, Tomoharu Yamada, Kazuhiko Koike, Koji Uchino, Ryosuke Tateishi, Takuma Nakatsuka, Tatsuya Minami, Kenichiro Enooku, Yotaro Kudo, Takahiro Kishikawa, Mizuki Nishibatake Kinoshita, Taijiro Wake, Ryo Nakagomi
Publikováno v:
Journal of Gastroenterology. 56:456-469
Liquid biopsies, particularly those involving circulating tumor DNA (ctDNA), are rapidly emerging as a non-invasive alternative to tumor biopsies. However, clinical applications of ctDNA analysis in hepatocellular carcinoma (HCC) have not been fully
Autor:
Maria V.T. Lobo, Patricia Sanmartín-Salinas, Miguel Toro Londoño, Fernando Noguerales-Fraguas, Antonio Jiménez-Ruiz, Luis G. Guijarro
Publikováno v:
Journal of Gastroenterology. 53:932-944
Insulin receptor substrate 4 (IRS-4) is an adaptor protein for which new evidence suggests plays a role in tumour promotion. We described nuclear IRS-4 in RKO colon cancer cell lines in biopsies of patients with colorectal cancer (CRC) (n = 20) and i
Autor:
You Lu, Zong-Guang Zhou, Yongyang Yu, Gunnar Arbman, Xianming Mo, Cun Wang, Ke-Ling Chen, Bin Zhou, Lie Yang, Yuan Li, Xiao-Feng Sun, Jin Zhou
Publikováno v:
Journal of Gastroenterology. 49:436-445
Currently, little is known regarding the role of peroxisome proliferator-activated receptor-β (PPAR β) in the vascular endothelial cells (VECs) of colorectal cancers (CRCs). The aim of this study was to investigate the relationship of PPAR β expre
Autor:
Katya Gudis, Taku Tsukui, Atsushi Tatsuguchi, Masafumi Kusunoki, Tetsuro Hiratsuka, Nobue Ueki, Akane Horie, Kazumasa Miyake, Seiji Futagami, Choitsu Sakamoto, Tomotaka Shindo, Tatsuhiko Hamamoto
Publikováno v:
Journal of Gastroenterology. 43:216-224
Recent studies have reported that expression of monocyte chemoattractant protein 1 (MCP-1) and its receptor (CCR2) and CD40 ligation on mesenchymal cells play important roles in tumor development. Cyclooxygenase 2 (COX-2) has also been shown to contr
Autor:
Kenji Fujiwara, Masashi Naito, Atsushi Matsui, Mie Inao, Sumiko Nagoshi, Nobuko Ito, Tohru Egashira, Hashimoto Michie, Satoshi Mochida, Makoto Nagano, Shunji Mishiro
Publikováno v:
Journal of Gastroenterology. 40:381-388
The T-helper (Th)1 immune reaction is essential for the eradication of hepatitis C virus (HCV) during interferon (IFN) therapy in patients with chronic hepatitis C. Osteopontin is a cytokine crucial for the initiation of the Th1 response. Recently, w
Publikováno v:
Journal of Gastroenterology. 39:783-787
Specific mutations in the cationic trypsinogen gene ( PRSS1) are disease-causing in patients with hereditary pancreatitis, but the genetic background still remains mysterious in about 40% of patients with the disease. It has been suggested that oxida
Autor:
Hidemitsu Sugai, Shigeo Kamei, Akihiro Takahashi, Hideki Amemiya, Yoshirou Matsumoto, Fumiko Ichihara, Hideki Fujii, Koji Kono
Publikováno v:
Journal of Gastroenterology. 38:540-547
Gastric cancers producing α-fetoprotein (AFP) are known to have a poor prognosis and to show a high incidence of liver metastasis. Vascular endothelial growth factor (VEGF) and its isoform VEGF-C are reported to be associated with tumor progression
Autor:
Masaru Sonoda, Saburou Murakami, Kiyoshi Ishida, Taiju Hashimoto, Akira Satomi, Moriyuki Matsuki
Publikováno v:
Journal of Gastroenterology. 30:177-182
The significance of superoxide dismutase (SOD) activity in colorectal cancer tissue was determined from the aspect of the antioxidant defense system. SOD activity and thiobarbituric acid reactive substance were measured in the tumor, in tissues adjac