Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Lionel Feigenbaum"'
Autor:
Lionel Feigenbaum, Frederick W. Alt, Susan Lim, Elsa Callen, Helena Tolarová, Michael Potter, Rafael Casellas, André Nussenzweig, Maria Mosaico, Wendy Dubois, Zhiyu Li, Makiko Takizawa, Sonia Franco
Publikováno v:
The Journal of Experimental Medicine
Immunoglobulin (Ig) isotype switching is a recombination event that changes the constant domain of antibody genes and is catalyzed by activation-induced cytidine deaminase (AID). Upon recruitment to Ig genes, AID deaminates cytidines at switch (S) re
Autor:
Patrick C. Wilson, Siegfried Janz, Rafael Casellas, Carolina Montaño, Zhiyu Li, F. Nina Papavasiliou, Makiko Takizawa, Stefan Fichtner-Feigl, Polyxeni Gourzi, Lionel Feigenbaum, Elizabeth E. Crouch
Publikováno v:
The Journal of Experimental Medicine
The B cell–specific enzyme activation-induced cytidine deaminase (AID) has been shown to be essential for isotype switching and affinity maturation of antibody genes during the immune response. Conversely, AID activity has also been linked to autoi
Autor:
Lionel Feigenbaum, Steven L. Reiner, S. Rhiannon Jenkinson, Rémy Bosselut, Guangping Sun, Andrew M. Intlekofer
Publikováno v:
The Journal of Experimental Medicine
Most T cells belong to either of two lineages defined by the mutually exclusive expression of CD4 and CD8 coreceptors: CD4 T cells are major histocompatibility complex (MHC) II restricted and have helper function, whereas CD8 T cells are MHC I restri
Publikováno v:
Journal of Experimental Medicine. 200:797-803
Intrathymic T cell development depends on signals transduced by both T cell receptor and cytokine receptors. Early CD4−CD8− (double negative) thymocytes require interleukin (IL)-7 receptor (IL-7R) signals for survival and proliferation, but IL-7R