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Autor:
Zhikun Ma, Stanley D. Kosanke, Erin W. Howard, Xiaoshan Feng, Amanda B. Parris, Zhengzheng Xiao, Xiaohe Yang
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Although chemopreventative agents targeting the estrogen/estrogen receptor (ER) pathway have been effective for ER+ breast cancers, prevention of hormone receptor-negative breast cancers, such as Her2/erbB-2+ breast cancers, remains a sign
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Nestin expression has been reported to be associated with the prognosis of many solid tumors including human hepatocellular carcinoma (HCC). The present study aimed to identify the role, if any, of Nestin in the chemotherapeutic treatment
Autor:
Jian-Xin Gao, Juanjie Bo, Qi Pan, Jiang-hua Yang, Lian-hua Zhang, Shan-Shan Liu, Mengyao Liu, Guoliang Yang, Ning Liu, Shi-Long Lin, Rulong Shen, Qiang Liu, Yiran Huang
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Metformin is the first line of oral antidiabetic drug in the biguanide class for treatment of type 2 diabetes. Increasing evidence has suggested that it is a potential anti-tumor drug. However, the mechanisms underlying inhibiting tumor de
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background One-third of estrogen (ER+) and/or progesterone receptor-positive (PGR+) breast tumors treated with Tamoxifen (TAM) do not respond to initial treatment, and the remaining 70% are at risk to relapse in the future. Estrogen-related receptor
Autor:
Yuan Wen, Li Pan, Huashan Shi, Xiang Chen, Zhi-Yong Li, Qing-Zhong Yuan, Chun-Ting Wang, Dan-Dan Yu, Fei Leng, Yuquan Wei
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 29, Iss 1, p 46 (2010)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background A high concentration of cisplatin (CDDP) induces apoptosis in many tumor cell lines. CDDP has been administered by infusion to avoid severe toxicity. Recently, it has been reported that changes in survivin expression or function may lead t
Autor:
Yuquan Wei, Zhiyong Qian, Xingyi Li, Yu-mei Wang, Xian-ping Liu, Zhi-yong Li, Zhengyu Li, Lina Zhou, Shengtao Zhou, Xiancheng Chen, Xia Zhao, Tao Yi, Qian Zhong, Xiang He
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 29, Iss 1, p 76 (2010)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Camptothecin (CPT) has recently attracted increasing attention as a promising anticancer agent for a variety of tumors. But the clinical application is largely hampered by its extreme water insolubility and unpredictable side effect. It is
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 30, Iss 1, p 57 (2011)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental and Clinical Cancer Research
Journal of Experimental and Clinical Cancer Research, BioMed Central, 2011, 30 (1), pp.57. ⟨10.1186/1756-9966-30-57⟩
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental and Clinical Cancer Research
Journal of Experimental and Clinical Cancer Research, BioMed Central, 2011, 30 (1), pp.57. ⟨10.1186/1756-9966-30-57⟩
Background Epidermal Growth Factor Receptor (EGFR) mutations, especially in-frame deletions in exon 19 (ΔLRE) and a point mutation in exon 21 (L858R) predict gefitinib sensitivity in patients with non-small cell lung cancer. Several methods are curr
Autor:
Jipei Zhao, Guodong Gao, Yanyang Tu, Jingyu Zhang, Jianhai Zong, Fuqiang Feng, Peigang Ji, Shiming He, Yongsheng Zhang, Liang Wang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 31, Iss 1, p 44 (2012)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
BackgroundChloride intracellular channel 1 (CLIC1) is expressed ubiquitously in human tissues and is involved in the regulation of cell cycle, cell proliferation and differentiation. Recent studies have shown that CLIC1 is highly expressed in several
Autor:
Francesco Pisani, Maria Concetta Petti, D. Assisi, Carlo Ludovico Maini, Rosa Sciuto, Mariella D'Andrea, Laura Dessanti
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 30, Iss 1, p 16 (2011)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background This retrospective analysis is focused on the efficacy and safety of radioimmunotherapy (RIT) with Zevalin® in nine patients with recurrent follicular lymphoma (FL) who were treated in a consolidation setting after having achieved complet
Autor:
María-Ester Brandan, Blanca Ivone Herrera-Penilla, Mario Alberto Castro-Morales, Enrique Pérez-Cárdenas, José Chanona-Vilchis, Patricia García-López, Rafael Jurado, Luis A. Medina
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 27, Iss 1, p 57 (2008)
Journal of Experimental & Clinical Cancer Research, Vol 27, Iss 1, p 57 (2008)
Background We explore the use of a clinical orthovoltage X-ray treatment unit as a small-animal radiation therapy system in a tumoral model of cervical cancer. Methods Nude mice were subcutaneously inoculated with 5 × 106 HeLa cells in both lower li