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Autor:
Jianwei Zhou, Sharad Sharma, Hangping Yao, Yong-Qing Zhou, Ming-Hai Wang, Ruiwen Zhang, Liang Feng
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Aberrant expression of the RON receptor tyrosine kinase, a member of the MET proto-oncogene family, in breast cancer and non-small cell lung cancer (NSCLC) has therapeutic implication. Here we evaluated the efficacy of a novel anti-RON ant
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background SIRT1 expression and Notch1 signaling have been implicated in tumorigenesis in many cancers, but their association with survival in breast cancer has not been determined. The purpose of this study was to assess the possible prognostic valu
Autor:
Chengfeng Xu, Leitao Sun, Yitong Hua, Zhenlin Yang, Jianli Dong, Yong Han, Kai Cheng, Zhongming Jia, Xiaohong Wang, Yuzhen Cui
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Release of exosomes have been shown to play critical roles in drug resistance by delivering cargo. Targeting the transfer of exosomes from resistant cells to sensitive cells may be an approach to overcome some cases of drug resistance. Met
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Breast cancer patients with positive estrogen receptor (ER) have a better prognosis. However, no prognostic miRNA signature was reported in the ER-positive breast cancer. The aim of the study was to identify and assess the prognostic signi
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Breast cancer is the most fatal malignant cancer among women, the conventional therapeutic modalities of it are limited. Morusin possesses cytotoxicity against some cancer cells in vitro. The purpose of this study is to test the growth inh
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background LKB1, also known as STK11, is a master kinase that serves as an energy metabolic sensor and is involved in cell polarity regulation. Recent studies have indicated that LKB1 is related to breast tumorigenesis and breast cancer progression.
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Many long non-coding RNAs(lncRNAs) have been found to be a good marker for several tumors. Using lncRNA-mining approach, we aimed to identify lncRNA expression signature that can predict breast cancer patient survival. Methods We performed
Autor:
Pierpaolo Gullo, Maurizio Costantini, Ernesto Maria Buccheri, Antonio Varanese, Roy De Vita, Marcello Pozzi, Giovanni Zoccali
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Introduction In women with macromastia, a type IV skin sparing mastectomy is often required to achieve an aesthetically pleasing reconstruction. The introduction of “skin-reducing mastectomy”, which inserts a permanent prosthetic device into a la
Autor:
Paolo Anibaldi, Valerio D'Orazi, Francesco Monteleone, Merola R, Silvia Iacobelli, Giulia Anna Follacchio, Giuseppe De Vincentis, Vittorio Pasta, Massimo Monti
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background The spread of mammographic screening programs has allowed an increasing amount of early breast cancer diagnosis. A modern approach to non-palpable breast lesions requires an accurate intraoperative localization, in order to achieve a compl
Autor:
Yuxuan Wang, Yongjie Xu, Genze Shao, Luzheng Xu, Shucong Meng, Jingyu Kuang, Xiaozhen Wang, Limei Guo, Li Li, Liandi Lei, Yanrong Su
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Epithelial-mesenchymal transition (EMT) is a crucial step for solid tumor progression and plays an important role in cancer invasion and metastasis. RNF8 is an ubiquitin E3 ligase with RING domain, and plays essential roles in DNA damage r