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Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Breast cancer is the most fatal malignant cancer among women, the conventional therapeutic modalities of it are limited. Morusin possesses cytotoxicity against some cancer cells in vitro. The purpose of this study is to test the growth inh
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background One-third of estrogen (ER+) and/or progesterone receptor-positive (PGR+) breast tumors treated with Tamoxifen (TAM) do not respond to initial treatment, and the remaining 70% are at risk to relapse in the future. Estrogen-related receptor
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 31, Iss 1, p 102 (2012)
Journal of Experimental & Clinical Cancer Research, Vol 31, Iss 1, p 102 (2012)
Background Acquired radioresistance of cancer cells remains a fundamental barrier to attaining the maximal efficacy of radiotherapy for the treatment of breast cancer. Anti-apoptotic proteins, such as Bcl-2 and Bcl-xL, play an important role in the r
Autor:
Teresa Klinowska, Massimo Cristofanilli, Emily Foster, Xiaoshen Dong, Chris Womack, Sandra V. Fernandez, Zhaomei Mu
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Introduction Epidermal growth factor receptor (EGFR) overexpression has been associated with prognostic and predictive value in inflammatory breast cancer (IBC). Epidermal growth factor receptor 2 (HER2) overexpression is observed at a higher rate in
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 30, Iss 1, p 102 (2011)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Breast cancer is one of the most diagnosed cancers in females, frequently with fatal outcome, so that new strategies for modulating cell proliferation in the mammary tissue are urgently needed. There is some, as yet inconclusive evidence t
Autor:
Nomeli P. Nunez, Amy W. Wong, Emily Schrader, Karen Poh, Qiwei X Paulson, Jina Hong, Renee E. Stubbins
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 30, Iss 1, p 75 (2011)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Alcohol consumption is an established risk factor for breast cancer metastasis. Yet, the mechanism by which alcohol promotes breast cancer metastases is unknown. The ability of cancer cells to invade through tissue barriers (such as baseme
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Nucleobindin 2 (NUCB2) protein, a novel oncoprotein, is overexpressed in breast cancer. To date, there have been no published data regarding the role of NUCB2 protein expression in prostate cancer (PCa). Therefore, this study was performed
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 28, Iss 1, p 93 (2009)
Journal of Experimental & Clinical Cancer Research, Vol 28, Iss 1, p 93 (2009)
Background Peroxiredoxins (Prxs) are a novel group of peroxidases containing high antioxidant efficiency. The mammalian Prx family has six distinct members (Prx I-VI) in various subcellular locations, including peroxisomes and mitochondria, places wh
Autor:
Xianrang Song, Li Xie, Jie Liu, Bao Song, Liyan Lv, Yan Zheng, Xingwu Wang, Ling Wei, Chuan-xi Wang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 29, Iss 1, p 29 (2010)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background MicroRNAs are non-coding RNA molecules that posttranscriptionally regulate expression of target genes and have been implicated in the progress of cancer proliferation, differentiation and apoptosis. The aim of this study was to determine w
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Mir-29 microRNA families are involved in regulation of various types of cancers. Although Mir-29 was shown to play an inhibitory role in tumorigenesis, the role of Mir-29 in breast cancer still remains obscure. In this study, we showed that Mir-29a i