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pro vyhledávání: ''
Autor:
C. Nelson Hayes, Eisuke Murakami, Wataru Okamoto, Kenichiro Kodama, Takashi Nakahara, Masami Yamauchi, Kazuaki Chayama, Daiki Miki, Tomokazu Kawaoka, Masataka Tsuge, Yuji Teraoka, Hiroshi Aikata, Michio Imamura, Yasutoshi Fujii, Shinsuke Uchikawa, Atsushi Ono, Hatsue Fujino
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
BackgroundThere has been a recent surge in interest in predicting biological effects associated with genomic alterations in order to implement personalized cancer treatment strategies. However, no reports have yet evaluated the utility of profiling b
Autor:
Fei Yan, Cheng ying Zhu, Li ping Dou, Hao Wang, Baoxu Pang, Yong hui Li, Meng zhen Wang, Xiao kai Wang, Dai hong Liu, Yu chen Liu, Chun ji Gao, Shujun Liu, Xiao su Chen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-19 (2020)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Induction therapy for acute myeloid leukemia (AML) is an anthracycline-based chemotherapy regimen. However, many patients experience a relapse or exhibit refractory disease (R/R). There is an urgent need for more effective regimens to reve
Autor:
Dongqing Guo, Weili Li, Xiaoqian Sun, Qian Zhang, Yanyan Jiang, Chun Li, Yong Wang, Qiyan Wang, Xiaoping Wang, Wenji Lu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-15 (2020)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Doxorubicin is effective in a variety of solid and hematological malignancies. Unfortunately, clinical application of doxorubicin is limited due to a cumulative dose-dependent cardiotoxicity. Dihydrotanshinone I (DHT) is a natural product
Autor:
Jing He, Mei Hong, Shiwang Li, Shao-tao Tang, Yuanyuan Chu, Jiarui Pu, Harish C. Joshi, Duo Li, Qiangsong Tong
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-16 (2020)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Runt-related transcription factor 1 (RUNX1) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters and can accelerate apoptosis in various tumors. However, the regulatory mechanisms underlyin
Autor:
Qi Zhou, Junbin Liao, Jianting Long, Sui Peng, Lixia Xu, Zhenwei Peng, Huilin Jin, Yu Guo, Shaoqiang Li, Guangyan Wei, Ming Kuang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-13 (2019)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Limited effective intervention for advanced hepatocellular carcinoma (HCC) is available. This study aimed to investigate the potential clinical utility of apatinib, a highly selective inhibitor of the vascular endothelial growth factor rec
Autor:
Yajie Xiong, Yan Wang, Zhongqin Liang, Yao Fei, Yi-fan Zhao, Xiao Shen, Ying Zhu, Anqi Wang, Long Wang, Wenjuan Wang, Fang Lin
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-13 (2019)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Cathepsin L (CTSL) is a cysteine protease known to have important roles in regulating cancer cellular resistance to chemotherapy. However mechanism underlying which regulates CTSL-mediated drug resistance remain largely unknown. Methods We
Autor:
María Díez-Campelo, Alejandro Pérez-Fernández, Angel Hernández-Hernández, Rodrigo Prieto-Bermejo, Carla Ijurko, Guillermo López-Ruano, Fermín Sánchez-Guijo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background The differentiation-based therapy for acute promyelocytic leukemia (APL) is an inspiring example for the search of novel strategies aimed at treatment of other subtypes of acute myeloid leukemia (AML). Thus, the discovery of new molecular
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-11 (2018)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Uncontrolled proliferation is thought to be the most fundamental characteristic of cancer. Detailed knowledge of cancer cell proliferation mechanisms would not only benefit understanding of cancer progression, but may also provide new clue
Autor:
Xiangge Tian, Bao-Jing Zhang, Xiaokui Huo, Xiaochi Ma, Lei Feng, Wei Cheng, Xun Wang, Bo Zhang, Qingjuan Hou, Dongdong Sun, Chao Wang, Zhenlong Yu, Yan Wang, Jin-Shan Xing, Cheng-Peng Sun, Yu-Long Lan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-14 (2017)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Glioblastoma multiforme (GBM) is one of the most refractory and palindromic central nervous system (CNS) neoplasms, and current treatments have poor effects in GBM patients. Hence, the identification of novel therapeutic targets and the de
Autor:
X P Zhang, Changtao Jiang, Jing Li, Yiqing Du, Caipeng Qin, Qiang Wang, Xiao-feng Wang, Tao Xu, Huaqi Yin, Zhengzuo Sheng
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-11 (2017)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background The involvement of lipid metabolism in tumourigenesis and the progression of clear cell renal cell carcinoma (ccRCC) have been reported. However, the role of phospholipid profile alterations in ccRCC has not yet been systematically explore