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Autor:
Xinxin Long, Qi Wang, Chenglai Xia, Jiazheng Li, Xuebiao Peng, Mingwei Shang, Yantao Cai, Yu Dai, Jiayi Xian
Publikováno v:
Journal of Dermatological Science. 105:27-36
Background Psoriasis is a chronic, complicated, and recurrent inflammatory skin disease. However, the precise molecular mechanisms remain largely elusive and the present treatment is unsatisfactory. Objective This study aimed to unravel the functions
Autor:
Masashi Akiyama
Publikováno v:
Journal of Dermatological Science. 105(1):11-17
Pustular psoriasis is a chronic inflammatory skin disease characterized by erythematous plaques with sterile pustules. It includes the distinct clinical entities generalized pustular psoriasis (GPP), acrodermatitis continua of Hallopeau (ACH) and pal
Autor:
Ian L. Chin, Yu Suk Choi, Fiona M. Wood, Manon Subilia, Mark W. Fear, Zhenjun Deng, Andrew W. Stevenson, Cecilia M Prêle, Nicole Hortin
Publikováno v:
Journal of Dermatological Science. 104:11-20
Background Fibroblasts found in keloid tissues are known to present an altered sensitivity to microenvironmental stimuli. However, the impact of changes in extracellular matrix stiffness on phenotypes of normal fibroblasts (NFs) and keloid fibroblast
Autor:
Hideya Uratsuji, Yoshihito Yamada, Hideki Watanabe, Sachi Mori, Kei Hashimoto, Tatsumi Matsumoto, Mika Fujikawa, Kota Sekiguchi
Publikováno v:
Journal of Dermatological Science. 104:21-29
Background C3H/HeJ mouse models progress gradually in hair loss from acute to chronic phase and reflect the symptoms of patients with alopecia areata (AA). However, the underlying pathological characteristics alteration associated with disease progre
Autor:
Mutsumi Yamanoi, Kenji Izumi, Osamu Sakata, Yoshiki Tokura, Yutaka Takahashi, Zinat Tamannaa, Do Huu Chi, Mitsutoshi Setou, Tetsuya Honda, Tomoaki Kahyo, A.S.M. Waliullah, Ariful Islam, Md. Mahmudul Hasan, Eri Kobayashi, Md. Al Mamun, Tomohito Sato, Eiji Naru, Kenji Kikushima
Publikováno v:
Journal of Dermatological Science. 103:143-150
Background The vermilion of the human lip presents characteristic features and undergoes aging faster than the skin. Therefore, knowledge of the vermilion surface-specific functional molecules is important to understand lip aging and formulate lip ca
Publikováno v:
Journal of Dermatological Science. 103:130-134
Human skin is a highly efficient self-renewing barrier that is critical to withstanding environmental insults. Undifferentiated keratinocyte stem cells reside in the basal layer of the epidermis and in hair follicles that continuously give rise to pr
Publikováno v:
Journal of Dermatological Science. 103:49-52
Autor:
Kota Sekiguchi, Sachi Mori, Shoichi Matsuda, Tatsumi Matsumoto, Yoshihito Yamada, Kei Hashimoto
Publikováno v:
Journal of Dermatological Science. 102:177-183
Background Alopecia areata (AA) is an autoimmune disease resulting in non-scarring hair loss. Animal models are useful means to identify candidates for therapeutic agents. The C3H/HeJ mouse AA model induced via transferring cultured lymphoid cells is
Autor:
Masayuki Amagai, Eric L. Simpson, Erin E. Grinich, Thomas A. Luger, Wilson Liao, Matthias Schmuth, Brigitte Dréno, Tamara Schikowski, Peter M. Elias, Kenji Kabashima, Ehrhardt Proksch, Marie Ange Dagnelie, Michel Simon
Publikováno v:
Journal of Dermatological Science. 102:142-157
Atopic dermatitis (AD) is a chronic, inflammatory skin disorder characterized by eczematous and pruritic skin lesions. In recent decades, the prevalence of AD has increased worldwide, most notably in developing countries. The enormous progress in our
Autor:
Lei Li, Peng Xu, Yongyan Dang, Jianru Xiao, Xiaoshuang Wang, Ying Yu, Lei Yuan, Zhipeng Wu, Qingwei Wang, Chan Jiao, Xiao Gao, Yining Ma, Yelin Wu
Publikováno v:
Journal of Dermatological Science. 102:101-108
Background REGγ acts as a proteasome activating factor mediating proteasome degradation of substrate proteins in an ATP and ubiquitination independent manner and also as an important regulator of cell cycle, proliferation and apoptosis. Hair cycle i