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pro vyhledávání: ''
Autor:
Hideya Uratsuji, Yoshihito Yamada, Hideki Watanabe, Sachi Mori, Kei Hashimoto, Tatsumi Matsumoto, Mika Fujikawa, Kota Sekiguchi
Publikováno v:
Journal of Dermatological Science. 104:21-29
Background C3H/HeJ mouse models progress gradually in hair loss from acute to chronic phase and reflect the symptoms of patients with alopecia areata (AA). However, the underlying pathological characteristics alteration associated with disease progre
Publikováno v:
Journal of Dermatological Science. 97:216-224
Background Sarcoidosis is a systemic granulomatous disease characterized by the combination of Th1 and Th17 responses. Recently, several arguments have suggested a potential involvement of B cells as well as T cells in the pathogenesis of sarcoidosis
Autor:
Noriko Arase, Tomo Kamitani, Daisuke Motooka, Mari Wataya-Kaneda, Kiyotoshi Sekiguchi, Ichiro Katayama, Daisuke Okuzaki, Hiroyuki Murota, Ryoko Sato-Nishiuchi
Publikováno v:
Journal of Dermatological Science. 96:73-80
Background Neurofibromas in von Recklinghausen's disease (vRD) can develop in the dermis. Therefore, we hypothesized that a dermal niche exists that promotes the development of these neurofibromas in subjects with vRD. Objective The purpose of this s
Publikováno v:
Journal of Dermatological Science. 94:298-305
Background Epidermal stem cells (ESCs) are keratinocytes that reside in the basal layer of the epidermis and mediate epidermal homeostasis. Insulin-like growth factor 1 (IGF-1) signaling through its receptor (IGF-1R) has been identified as an importa
Autor:
Yang Han, Rui-Qun Qi, Yu-Zhe Sun, Li-Li Zhu, Ya-Li Gao, Yu-Jing Zhang, Yang Yang, Yi Ren, Hong-Duo Chen, Xing-Hua Gao
Publikováno v:
Journal of Dermatological Science. 91:256-267
Background Hyperthermia is an effective treatment against cancer and human papillomavirus (HPV) infection. Previous studies have shown that heat shock proteins are crucial to the action of hyperthermia. Objectives To examine the effects of hypertherm
Publikováno v:
Journal of Dermatological Science. 91:250-255
Background De novo hair regeneration occurs in scars of normal adult mice. This interesting phenomenon is termed as wound-induced hair neogenesis (WIHN). We hypothesized that M2 macrophages are crucially involved in WIHN. Objective To clarify the con
Autor:
Johan Engblom, Zdenka Prgomet, Lars Ohlsson, Tautgirdas Ruzgas, Skaidre Jankovskaja, Anna Gustafsson, Anette Gjörloff Wingren
Publikováno v:
Journal of dermatological science. 99(3)
BACKGROUND: Interferon-gamma (IFN-γ) represents a potent inducer for keratinocyte inflammatory and immune activation in vitro. Since tryptophan (trp) conversion to kynurenine (kyn) is involved in inflammation, the topical kyn/trp ratio may serve as
Autor:
Seon Pil Jin, Zhenyu Li, Jin Ho Chung, Yoen Kyung Kim, Eun Young Seo, Soyun Cho, Eun Kyung Choi, Serah Lee
Publikováno v:
Journal of Dermatological Science. 91:175-183
Background Particulate matter (PM) is an integral part of air pollution, which is a mixture of particles suspended in the air. Recently, it has been reported that PM is associated with increased risks of skin diseases, especially atopic dermatitis in
Autor:
Manyun Mao, Jie Li, Ni Tang, Yingfang Wu, Ying Wang, Youyou Zhou, Cong Peng, Juan Li, Wei Zhang, Xiang Chen
Publikováno v:
Journal of dermatological science. 102(1)
Background Mast cells play an important role in allergic responses and persistently exposure to environmental fine particulate matter (PM2.5) exacerbates allergic diseases,but the details remained elucidative. Objectives To investigate the effect of
Autor:
Hye In Choi, Chang Yup Shin, Sungjoo Tommy Hwang, Kyu Han Kim, Dong Young Kim, Soon Jin Choi, Oh Sang Kwon
Publikováno v:
Journal of Dermatological Science. 91:60-68
Background Cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, increases the intracellular level of cyclic adenosine monophosphate to cause vasodilation. Topical application of cilostazol is reported to improve local blood flow and enhance wound heal