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Autor:
Ian L. Chin, Yu Suk Choi, Fiona M. Wood, Manon Subilia, Mark W. Fear, Zhenjun Deng, Andrew W. Stevenson, Cecilia M Prêle, Nicole Hortin
Publikováno v:
Journal of Dermatological Science. 104:11-20
Background Fibroblasts found in keloid tissues are known to present an altered sensitivity to microenvironmental stimuli. However, the impact of changes in extracellular matrix stiffness on phenotypes of normal fibroblasts (NFs) and keloid fibroblast
Publikováno v:
Journal of Dermatological Science. 103:130-134
Human skin is a highly efficient self-renewing barrier that is critical to withstanding environmental insults. Undifferentiated keratinocyte stem cells reside in the basal layer of the epidermis and in hair follicles that continuously give rise to pr
Autor:
Kota Sekiguchi, Sachi Mori, Shoichi Matsuda, Tatsumi Matsumoto, Yoshihito Yamada, Kei Hashimoto
Publikováno v:
Journal of Dermatological Science. 102:177-183
Background Alopecia areata (AA) is an autoimmune disease resulting in non-scarring hair loss. Animal models are useful means to identify candidates for therapeutic agents. The C3H/HeJ mouse AA model induced via transferring cultured lymphoid cells is
Publikováno v:
Journal of Dermatological Science. 102:94-100
Background Skin aging is marked by progressive loss in elastin and collagen that causes wrinkling and sagging of skin. Tropoelastin (TE) is the precursor monomer of elastin secreted by cells that cross-links extracellularly to create functional elast
Publikováno v:
J Dermatol Sci
Background Aged human skin is primarily attributable to the loss of collagen. Hepatocyte growth factor (HGF) acts as an anti-fibrotic factor by suppression of collagen production. In aged human skin, HGF is elevated in dermal fibroblasts and thus con
Publikováno v:
Journal of Dermatological Science. 101:134-137
Publikováno v:
Journal of Dermatological Science. 100:99-109
Background Lichen sclerosus (LS) is an acquired inflammatory mucocutaneous disease affecting the anogenital area, characterized histologically by hyalinosis and thickened vessel walls in the dermis. The presence of serum autoantibodies against extrac
Publikováno v:
Journal of Dermatological Science. 98:102-108
Background 585 nm light-emitting diodes have been proven to suppress melanogenesis in melanocytes. However, whether LEDs will influence normal human epidermal keratinocytes (NHEKs) and paracrine effect of LEDs-irradiated NHEKs in melanogenesis remain
Autor:
Ines Jakob, Robert Sabat, Ramona Schmid, Christian T. Wohnhaas, Denis Delic, Franziska Wiech, Demetrios Christou, Patrick Baum, Kathrin Rieber, Manuela Griesser, Kerstin Wolk, Georgios Kokolakis, E. Witte‐Händel, Marcel Rolser, Ogsen Gabrielyan
Publikováno v:
Journal of Dermatological Science. 97:9-20
Background Psoriasis is a chronic inflammatory disease characterized by demarcated, raised, and scaling skin lesions. It often serves as a model for immune-mediated disorders. Gene expression profiling of affected skin has allowed insights into psori
Autor:
Daisuke Nanba
Publikováno v:
Journal of Dermatological Science. 96:66-72
Human keratinocyte cultures contain keratinocyte stem cells, and have been involved in significant progress regarding stem cell biology as well as keratinocyte biology. Such cultures have also been applied in cell therapy for extensive severe burns f