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Autor:
Cynthia X. Ma, Eric J. Lenze, Tahir Rahman, Michael D. Yingling, Benoit H. Mulsant, Cory Patrick, Charles F. Reynolds, Ginger E. Nicol, Sarah M. Hartz
Publikováno v:
Journal of clinical psychopharmacology. 41(1)
Background Antipsychotic drugs are well established to alter serum prolactin levels, often resulting in adverse effects including amenorrhea, galactorrhea, osteoporosis, and loss of libido. There is growing preclinical evidence that prolactin-elevati
Autor:
Joseph Gao, M. Celeste Ferreira-Cornwell, Patricia Donnelly, Gary Zammit, Thomas Roth, Jon Freeman, Maria Gasior
Publikováno v:
Journal of Clinical Psychopharmacology. 34:642-644
In a study of acute sleep deprivation in healthy male volunteers randomized to double-blind treatment with lisdexamfetamine dimesylate (20, 50, or 70 mg), placebo control, or an active control (armodafinil 250 mg), Maintenance of Wakefulness Test dat
Autor:
Ryan Wright, Jill Chappell, Malcolm I. Mitchell, Richard Kovacs, Harry Haber, Beth A. Pangallo, Michael J. Detke
Publikováno v:
Journal of Clinical Psychopharmacology. 33:236-239
A decrease in heart rate variability (HRV) can indicate increased sympathetic nervous system activity and possibly increased norepinephrine levels. In this randomized, placebo- and escitalopram (ESC)-controlled, subject-blind, 2-period, crossover stu
Autor:
Tolani O. Ajagbe, Zsuzsa Szombathyne Meszaros, Steven L. Batki, Dongliang Wang, Jacqueline A. Dimmock, Ynesse Abdul-Malak
Publikováno v:
Journal of Clinical Psychopharmacology. 33:243-247
Alcohol and nicotine dependence are common in schizophrenia. Varenicline is effective in smoking cessation and has also been shown to decrease alcohol consumption in smokers. The present pilot study assessed the safety and effectiveness of vareniclin
Autor:
Robert A. Schoevers, Durk Wiersma, Edwin R. van den Heuvel, Marrit K. de Boer, Henderikus Knegtering, Johannes M. Oolders
Publikováno v:
Journal of Clinical Psychopharmacology, 34(3), 380-382. LIPPINCOTT WILLIAMS & WILKINS
Autor:
Robert M. Berman, Andrei Pikalov, Ronald N. Marcus, Quynh-Van Tran, Stephen R. Wisniewski, Maurizio Fava, Ross A. Baker, Huyuan Yang, Michael E. Thase
Publikováno v:
Journal of Clinical Psychopharmacology. 29:362-367
In 2 identical multicenter, double-blind, placebo-controlled trials, an 8-week prospective treatment phase to ensure inadequate response to standard antidepressants was followed with 6 weeks of aripiprazole (2-20 mg/d) or placebo, plus a standard ant
Autor:
Manuel J. Barbanoj, Consuelo García-Gea, Román Valiente, Joan Martínez-Colomer, Rosa M. Antonijoan
Publikováno v:
Journal of Clinical Psychopharmacology. 28:675-685
Peripheral anti-H1 and central nervous system (CNS) activities after single (day 1) and repeated (day 7) administrations of increasing doses of bilastine (BIL) were assessed in 20 healthy volunteers throughout a crossover, randomized, double-blind, p
Autor:
Bo Söderpalm, Andrea de Bejczy
Publikováno v:
Journal of clinical psychopharmacology. 35(1)
The number of therapeutic drugs available for the treatment of alcohol use disorders (AUDs) is limited, and a well-tolerated, self-administrable drug is much needed. Subgroups of alcohol-dependent individuals, for example, individuals with heredity f
Publikováno v:
Journal of Clinical Psychopharmacology. 25:589-592
Sildenafil used as oral drug treatment for erectile dysfunction is predominantly metabolized by the cytochrome P450 isozyme 3A4. The antidepressant fluvoxamine is an inhibitor of cytochrome P450 3A4. In a randomized, double-blind, placebo-controlled,
Autor:
William R. Harlan, Corette B. Parker, Louise Ritz, Richard I. Shader, David J. Greenblatt, K. Ranga Rama Krishnan, Kishore M. Gadde, Benedetto Vitiello, Jonathan R. T. Davidson
Publikováno v:
Journal of Clinical Psychopharmacology. 25:243-249
Background A previously reported clinical trial of Hypericum perforatum (St John's wort) in depression did not demonstrate efficacy. We assessed treatment adherence by measuring plasma hyperforin and evaluated the possible impact of adherence on stud