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Publikováno v:
Journal of clinical psychopharmacology. 39(6)
Background The negative symptoms of schizophrenia pose a heavy burden on patients and relatives and represent an unmet therapeutic need. The observed association of negative symptoms with impaired reward system function has stimulated research on pro
Publikováno v:
Journal of Clinical Psychopharmacology. 36:720-723
INTRODUCTION The aim of this study is to evaluate the efficacy of duloxetine augmentation in treatment of resistant obsessive-compulsive disorder (OCD). METHODS This augmentation trial was designed as an 8-week randomized controlled, double-blind stu
Autor:
Roger M. Lane, Anne Torbeyns, Arif Khan, Boadie W. Dunlop, Delphine Hennicken, Craig Nelson, Richard H. Weisler, Michael E. Thase, Ming Zheng, Sanjay J. Mathew, Richard C. Shelton, Zubin Bhagwagar
Publikováno v:
Journal of Clinical Psychopharmacology. 35:454-459
Two phase 2B, randomized, double-blind studies assessed the efficacy and safety of fixed or flexible dose of triple monoamine uptake inhibitor BMS-820836 in patients with treatment-resistant depression to demonstrate whether switching to BMS-820836 w
Autor:
Ali Akhoundpour Manteghi, Mohammad Mortezania, Mehri Baghban Haghighi, Arash Javanbakht, Paria Hebrani
Publikováno v:
Journal of Clinical Psychopharmacology. 34:240-243
Posttraumatic stress disorder (PTSD) is a chronic disabling illness, resulting from exposure to extreme traumatic event. Although different pharmacologic agents are suggested for treatment of PTSD, none have been completely effective in eliminating s
Autor:
Tolani O. Ajagbe, Zsuzsa Szombathyne Meszaros, Steven L. Batki, Dongliang Wang, Jacqueline A. Dimmock, Ynesse Abdul-Malak
Publikováno v:
Journal of Clinical Psychopharmacology. 33:243-247
Alcohol and nicotine dependence are common in schizophrenia. Varenicline is effective in smoking cessation and has also been shown to decrease alcohol consumption in smokers. The present pilot study assessed the safety and effectiveness of vareniclin
Autor:
Alireza Emadossadat, Mehrdad Salehi, Mohammad Reza Maracy, Gholam Reza Kheirabadi, Mohammad Reza Sharbafchi
Publikováno v:
Journal of clinical psychopharmacology. 35(6)
Methamphetamine (METH) abuse and dependence present a major global problem. We investigated the efficacy of adding buprenorphine in reducing METH cravings during treatment with the Matrix program.This was a randomized, double-blind, controlled clinic
Publikováno v:
Journal of Clinical Psychopharmacology. 26:152-156
Motor vehicle accidents (MVAs) are a leading cause of posttraumatic stress disorder (PTSD) in the general population. Alterations in norepinephrine and serotonin systems have been proposed as mechanisms involved in the pathophysiology of the conditio
Autor:
Bo Söderpalm, Andrea de Bejczy
Publikováno v:
Journal of clinical psychopharmacology. 35(1)
The number of therapeutic drugs available for the treatment of alcohol use disorders (AUDs) is limited, and a well-tolerated, self-administrable drug is much needed. Subgroups of alcohol-dependent individuals, for example, individuals with heredity f
Autor:
William R. Harlan, Corette B. Parker, Louise Ritz, Richard I. Shader, David J. Greenblatt, K. Ranga Rama Krishnan, Kishore M. Gadde, Benedetto Vitiello, Jonathan R. T. Davidson
Publikováno v:
Journal of Clinical Psychopharmacology. 25:243-249
Background A previously reported clinical trial of Hypericum perforatum (St John's wort) in depression did not demonstrate efficacy. We assessed treatment adherence by measuring plasma hyperforin and evaluated the possible impact of adherence on stud
Autor:
Maria Celeste Ferreira-Cornwell, Thomas Roth, Maria Gasior, Patricia Donnelly, Gary K. Zammit, Joseph Gao, Jon Freeman
Publikováno v:
Journal of clinical psychopharmacology. 34(6)
This study evaluated daytime alertness and performance with lisdexamfetamine dimesylate during acute sleep loss. In a randomized, double-blind study in healthy adult men (n = 135) undergoing 24-hour sleep loss, the alerting effects of single oral lis