Zobrazeno 1 - 10
of 54
pro vyhledávání: ''
Autor:
Alessandro Antonelli, Bruno Perrucci, Michele Milella, Roberto Iacovelli, Matteo Brunelli, Giovanni L. Pappagallo, Maria Angela Cerruto, Cinzia Baldessari, Stefano Panni, Alessandra Mosca, Giuseppe Fornarini, Luca Cima, Roberto Sabbatini, Anna Caliò, Alessandro Tafuri, Guido Martignoni, Elena Verzoni, Maria Olga Giganti, Valerio Gaetano Vellone, Giuseppe Procopio, Filippo Alongi, Marcello Tucci, Rodolfo Passalacqua, Sara Elena Rebuzzi, Cinzia Ortega, Melissa Bersanelli, Maddalena Donini, Andrea Zivi, Sergio Bracarda, Enrico Munari, Camillo Porta, Albino Eccher, Veronica Prati, Sebastiano Buti
Publikováno v:
Journal of clinical pathology. 75(1)
AimsAccording to The Cancer Genome Atlas (TCGA), around 9% of bladder carcinomas usually show abnormalities of the murine double minute 2 (MDM2) gene, but a few studies have been investigated them. We profiled MDM2 gene amplification in a series of u
Autor:
Puay Hoon Tan, Murasaki Ikeda, Joe Yeong, Bernett Lee, Jabed Iqbal, Jeffrey Chun Tatt Lim, Seigo Nakamura, Aye Aye Thike
Publikováno v:
Journal of Clinical Pathology. 71:161-167
BackgroundTriple-negative breast cancers (TNBCs) are defined by their lack of oestrogen receptor, progesterone receptor and epidermal growth factor receptor 2. Although heterogeneous, the majority are aggressive and treatment options are limited. Cav
Autor:
Ann Boguniewicz, Tony El Jabbour, Katherine B. Geiersbach, David M. Jones, Sanaz Ainechi, Mary P. Bronner, Christine E. Sheehan, Jeffrey S. Ross, Kajsa E. Affolter, Hwajeong Lee
Publikováno v:
Journal of Clinical Pathology. 71:46-51
AimsRoutine application of PD-L1 immunohistochemistry (IHC) in colorectal cancer (CRC) is limited due to lack of standardized scoring criteria, antibody clones, and intratumoral staining heterogeneity. We assessed PD-L1 protein expression on full fac
Publikováno v:
Journal of Clinical Pathology. 70:899-902
The recent publication reviewing the updated WHO classification commented on the presence of cyclin D1-positive cells in the proliferation centres (PC) of small lymphocytic lymphoma/chronic lymphocytic leukaemia (SLL/CLL). The figure quoted was 30%,
Autor:
Hallie Kretsinger, Tina Schaller, Beate Paul, Bernadette Kriening, Gerhard Schenkirsch, Bruno Märkl
Publikováno v:
Journal of Clinical Pathology. 70:443-447
Recently, we demonstrated that the intratumoural density of CD3+ and CD8+ T cells is independently prognostic and associated with lymph node (LN) harvest and LN size in node-negative colon cancer. We assumed that FOXP3+ T cells (Tregs) could be inver
Autor:
Daniel Olsen, James deKay, Takamaru Ashikaga, Mark Evans, Zhouwei Zhang, Zhihua Peng, Donald L. Weaver
Publikováno v:
Journal of Clinical Pathology. 69:76-81
Aim Long non-coding RNAs (lncRNAs) are potential biomarkers for breast cancer risk stratification. LncRNA expression has been investigated primarily by RNA sequencing, quantitative reverse transcription PCR or microarray techniques. In this study, si
Autor:
Eszter Turányi, A. Marcell Szász, Zoltán Hanzély, Lilla V. Lukács, Gabriella Arató, Janina Kulka, István Kenessey, Anna Maria Tokes, János Fillinger, Katalin Bálint, Nora Meggyeshazi, Miklos Szendroi, István Arthur Molnár, Ibolya Soltesz, Franciska Geszti
Publikováno v:
Journal of Clinical Pathology. 68:274-282
AimsTo assess the expression of the following cell cycle regulatory proteins in primary metastatic breast carcinomas (MBCs) and on availability in matched distant metastases (DMs): Ki67, cyclin A, geminin and aurora-kinase A (aurkA); and to compare t
Autor:
Gesa Schuebbe, Helge Siemens, Rolf D. Issels, Sebastian Gibis, Thomas Kirchner, Eric Kampmann, Thomas Knösel, Heiko Hermeking, Annelore Altendorf-Hofmann, Lars H. Lindner
Publikováno v:
Journal of Clinical Pathology. 67:592-598
Aims p16(INK4a) is an important factor in carcinogenesis, and its expression is linked to oncogene-induced senescence. Very recently it was shown that upregulation and downregulation of p16 indicates a senescence barrier in the serrated route of colo
Publikováno v:
Journal of Clinical Pathology. 66:758-763
To investigate the expression of inhibitor of differentiation/DNA binding (Id-1), phosphatidylinositol-3-kinase/protein kinase B pathway proteins and hyperthermia-associated protein and their association with various clinicopathological factors in or
Autor:
Peter Malfertheiner, Zsolt Tulassay, Kinga Tóth, Michael Selgrad, Jan Bornschein, Béla Molnár, Doerthe Kuester, Thomas Wex
Publikováno v:
Journal of Clinical Pathology. 66:819-822
The interplay between gastric and intestinal transcription factors has an important impact on gastric carcinogenesis. We compared the gene expression of CDX1, CDX2, SOX2 and related downstream genes in tumour and tumour surrounding gastric tissue of