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Autor:
Masahiro Kashiwaba, Tsuyoshi Saito, Michiko Tsuneizumi, Hiroji Iwata, Noriko Sagawa, Hiroaki Kawashima, Takuya Kawahara, Miki Yamaguchi, Yasuo Ohashi, Tsutomu Takashima, Masataka Sawaki, Toshiro Mizuno, Naruto Taira, Shinichi Baba, Yutaka Yamamoto, Hirofumi Mukai, Yukari Uemura, Takahiro Nakayama, Hiroko Bando, Masato Takahashi, Kokoro Kobayashi
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 38(32)
PURPOSE Adjuvant trastuzumab monotherapy has not been compared with trastuzumab + chemotherapy. We investigated the relative value of trastuzumab monotherapy for older patients with breast cancer. METHODS This study was an open-label, randomized cont
Autor:
Julia Bonastre, Francoise Callonnec, Sonia Zilberman, I. Jaffré, Claire Chapellier, Nicole Guérin, Philippe Rauch, Marguerite Kandel, Jean-Rémi Garbay, Gilles Houvenaeghel, Pascal Cherel, Ariane Dunant, Marie-Christine Mathieu, Françoise Rimareix, Philippe Henrot, Chafika Mazouni, Ines Raoust, Aurélie Jalaguier, Isabelle Doutriaux-Dumoulin, Marie-Pierre Chauvet, Luc Ceugnart, Corinne Balleyguier, Jocelyne Chopier
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37(11)
PURPOSE We evaluated the addition of breast magnetic resonance imaging (MRI) to standard radiologic evaluation on the re-intervention rate in women with ductal carcinoma in situ (DCIS) undergoing breast-conserving surgery. PATIENTS AND METHODS Women
Autor:
Kala Visvanathan, Catherine Pesce, Bradley M. Turner, Lorraine Tafra, Stacie Jeter, David G. Hicks, Leslie Cope, Maria Cristina Figueroa-Magalhães, Ashley Cimino-Mathews, Charles Mylander, Deborah K. Armstrong, Dylan V. Miller, Tyler A. Jensen, Robert S. Miller, Vered Stearns, Hyun-Seok Kim, Martin Rosman, Christopher B. Umbricht, Antonio C. Wolff, Ben Ho Park, John H. Fetting, Roisin M. Connolly, Peter B. Illei, Soonweng Cho, Nivedita Chowdhury
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34(36)
Purpose Gene expression profiling assays are frequently used to guide adjuvant chemotherapy decisions in hormone receptor–positive, lymph node–negative breast cancer. We hypothesized that the clinical value of these new tools would be more fully
Autor:
Nadine Tung, Judy Garber, John Kidd, Brian Allen, Eric P. Winer, Anne-Renee Hartman, Richard J. Wenstrup, Nan Lin, Nanda Singh
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34(13)
Purpose Testing for germline mutations in BRCA1/2 is standard for select patients with breast cancer to guide clinical management. Next-generation sequencing (NGS) allows testing for mutations in additional breast cancer predisposition genes. The fre
Autor:
Rosalind P. Candelaria, Kelly K. Hunt, Dalliah M. Black, Benjamin Smith, Henry Mark Kuerer, Isabelle Bedrosian, Savitri Krishnamurthy, Elizabeth A. Mittendorf, Gildy Babiera, Mariana Chavez-MacGregor, Abigail S. Caudle, Basak E. Dogan, Rosa F. Hwang, Beatriz E. Adrada, Michael Z. Gilcrease, Lumarie Santiago, Simona F. Shaitelman, Brian P. Hobbs, Sarah M. DeSnyder, Wei T. Yang
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34(10)
Purpose Placing clips in nodes with biopsy-confirmed metastasis before initiating neoadjuvant therapy allows for evaluation of response in breast cancer. Our goal was to determine if pathologic changes in clipped nodes reflect the status of the nodal
Autor:
Nina R. Horowitz, Vicky Q. Yang, Brandon Hayse, Brigid K. Killelea, Donald R. Lannin, Lajos Pusztai, Sarah S. Mougalian, Shi-Yi Wang, Anees B. Chagpar
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 33(36)
Purpose To explore racial differences in the use and outcome of neoadjuvant chemotherapy for breast cancer. Methods The National Cancer Data Base was queried to identify women with stage 1 to 3 breast cancer diagnosed in 2010 and 2011. Chemotherapy u
Autor:
Joseph A. Sparano, William C. Wood, Edith A. Perez, Nancy E. Davidson, Tom Saphner, Fengmin Zhao, Jennifer A. Ligibel, George W. Sledge, Antonio C. Wolff, Silvana Martino
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 33(21)
Purpose To determine long-term outcomes in a clinical trial evaluating the role of taxane type and schedule in operable breast cancer and evaluate the impact of obesity and black race on outcome. Patients and Methods A total of 4,954 eligible women w
Autor:
Douglas W. Blayney, Jane C. Weeks, Richard L. Theriault, Rebecca A. Ottesen, Y. Wong, Ann H. Partridge, Erica T. Warner, Melissa E. Hughes, Eric P. Winer, Joyce C. Niland, Rulla M. Tamimi, Stephen B. Edge
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 33(20)
Purpose To evaluate the relationship between race/ethnicity and breast cancer–specific survival according to subtype and explore mediating factors. Patients and Methods Participants were women presenting with stage I to III breast cancer between Ja
Autor:
Elizabeth Crowley, Linda T. Vahdat, Randa Loutfi, Rebecca Bechhold, Robert Weaver, Michael Yellin, Dennis Citrin, Thomas Hawthorne, Thomas A. Davis, Scott Cruickshank, Francis P. Arena, Denise A. Yardley, Andres Forero, Michelle E. Melisko, Ira Oliff, Mansoor N. Saleh, Alison Stopeck, Tessa Cigler, Agustin A. Garcia, Jennifer Green
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 33(14)
Purpose Glycoprotein NMB (gpNMB), a negative prognostic marker, is overexpressed in multiple tumor types. Glembatumumab vedotin is a gpNMB-specific monoclonal antibody conjugated to the potent cytotoxin monomethyl auristatin E. This phase II study in
Autor:
Leigh Neumayer, Kala Visvanathan, Melissa E. Hughes, Keith Stockerl-Goldstein, Beverly Moy, Hope S. Rugo, Jane C. Weeks, Amanda L. Blackford, R. L. Theriault, Lori J. Goldstein, Judith E. Karp, Terry S. Langbaum, Antonio C. Wolff
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 33, iss 4
Purpose Outcomes for early-stage breast cancer have improved. First-generation adjuvant chemotherapy trials reported a 0.27% 8-year cumulative incidence of myelodysplastic syndrome/acute myelogenous leukemia. Incomplete ascertainment and follow-up ma