Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Langone, A"'
Autor:
Marwan Fakih, Dung T. Le, Katrina Sophia Pedersen, Anthony Frank Shields, Manish A. Shah, Sarbajit Mukherjee, Patricia Delaite, Théa Faivre, Anna Morena D'Alise, Guido Leoni, Gabriella Cotugno, Francesca Langone, Elisa Scarselli, Michael J. Overman
Publikováno v:
Journal of Clinical Oncology. 40:2515-2515
2515 Background: Defective DNA mismatch repair (dMMR) leads to high levels of microsatellite-instability (MSI-H) and insertions or deletions in coding regions, triggering the generation of tumor-specific frameshift peptides (FSPs). We selected 209 sh
Autor:
C. Millward, Greg Yothers, Kim M. Clark-Langone, Steven Shak, Margarita Lopatin, Saima Sharif, Michael O’Connell, Norman Wolmark, Mark Lee, Soonmyung Paik
Publikováno v:
Journal of Clinical Oncology. 31:4512-4519
Purpose Accurate assessments of recurrence risk and absolute treatment benefit are needed to inform colon cancer adjuvant therapy. The 12-gene Recurrence Score assay has been validated in patients with stage II colon cancer from the Cancer and Leukem
Autor:
C. Millward, Donna Niedzwiecki, Xing Ye, Kim M. Clark-Langone, Mark Lee, Margarita Lopatin, Paula N. Friedman, Alan P. Venook, Robert S. Warren, Monica M. Bertagnolli, Richard L. Schilsky, Steven Shak, Wendy L. Frankel, Najjia N. Mahmoud, Richard M. Goldberg
Publikováno v:
Journal of Clinical Oncology. 31:1775-1781
Purpose A greater understanding of the biology of tumor recurrence should improve adjuvant treatment decision making. We conducted a validation study of the 12-gene recurrence score (RS), a quantitative assay integrating stromal response and cell cyc
Autor:
Kelly Handley, C Beaumont, Margarita Lopatin, David J. Kerr, Philip Quirke, Steven Shak, Laura Magill, Carl Yoshizawa, Kim M. Clark-Langone, Mark Lee, Richard Gray, Drew Watson, Frederick L. Baehner
Publikováno v:
Journal of Clinical Oncology. 29:4611-4619
Purpose We developed quantitative gene expression assays to assess recurrence risk and benefits from chemotherapy in patients with stage II colon cancer. Patients and Methods We sought validation by using RNA extracted from fixed paraffin-embedded pr
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Autor:
Anthony Langone, Rebecca Hung, Robert F. Cornell, Stacey Goodman, Kevin T. McDonagh, Sara N. Horst, Samuel M. Rubinstein, Ilka Decker, Mark P. Steele, Oluchi C. Ukaegbu, Kyle T Rawling, Daniel J. Lenihan, Sharon Phillips, Robert D. Hoffman, Adetola A. Kassim, Shelton Lacy
Publikováno v:
Journal of Clinical Oncology. 33:e19539-e19539
e19539 Background: Light chain amyloidosis (AL) is characterized by the accumulation of misfolded proteins that deposit in tissue causing multisystem organ dysfunction. Current treatments target pl...
Autor:
Mark A Lee, Haluk Tezcan, Margarita Lopatin, Kim M. Clark-Langone, Steven Shak, Amy P. Sing, Emily Burke
Publikováno v:
Journal of Clinical Oncology. 32:523-523
523 Background: The 12-gene colon cancer assay is the first commercially available molecular assay to predict the risk of recurrence in stage II/III colon and rectal cancer. Rigorous evidence for clinical validity and utility of an assay is imperativ
Akademický článek
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Autor:
Greg Yothers, Saima Sharif, Michael J. O'Connell, Kim M. Clark-Langone, C. Millward, Margarita Lopatin, Mark A Lee, Steven Shak, Norman Wolmark, Soonmyung Paik
Publikováno v:
Journal of Clinical Oncology. 30:3512-3512
3512 Background: Standardized clinical tools which accurately quantify recurrence risk are needed for optimal adjuvant treatment of colon cancer. The 12-gene RS has been validated in stage II colon cancer pts from QUASAR and CALGB 9581. We conducted
Akademický článek
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