Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ernest S. Smith"'
Autor:
Desa Rae Pastore, Kevin M. Chin, Nashat Y. Gabrail, JT Beck, Aaron S. Mansfield, Andreas Schröder, Alexander I. Spira, Yanyan Lou, Michael Shafique, Crystal Mallow, Megan Ann Baumgart, Terrence L. Fisher, Ernest S. Smith, Rachel E. Sanborn, Nagashree Seetharamu, Maurice Zauderer, Elizabeth E. Evans, Ramaswamy Govindan, John E. Leonard, Jonathan W. Goldman
Publikováno v:
Journal of Clinical Oncology. 38:3011-3011
3011 Background: Antibody blockade of semaphorin 4D (SEMA4D, CD100) promotes tumoral dendritic cell and CD8+ T cell infiltration and reduces function and recruitment of immunosuppressive myeloid cells. Importantly, these mechanisms to overcome immune
Autor:
Andreas Schröder, Ramaswamy Govindan, Elizabeth E. Evans, Jonathan W. Goldman, John E. Leonard, Nagashree Seetharamu, Kevin M. Chin, Megan Ann Baumgart, Desa Rae Pastore, Yan Yan Lou, Rachel E. Sanborn, Aaron S. Mansfield, Nashat Y. Gabrail, Terrence L. Fisher, J. Thaddeus Beck, Ernest S. Smith, Maurice Zauderer, Alexander I. Spira, Crystal Mallow, Michael Shafique
Publikováno v:
Journal of Clinical Oncology. 38:75-75
75 Background: Despite progress of immune checkpoint therapies, many cases of non-small cell lung cancer (NSCLC) are refractory or acquire resistance to current therapies. Antibody blockade of semaphorin 4D (SEMA4D, CD100) can overcome resistance mec
Autor:
L. A. Winter, Raymond Watkins, Alan S. Jonason, Terrence L. Fisher, J. Seils, John E. Leonard, Maurice Zauderer, Ernest S. Smith, C. A. Cornelius, Christine Reilly
Publikováno v:
Journal of Clinical Oncology. 29:e13071-e13071
e13071 Background: VX15/2503 is a humanized IgG4 monoclonal antibody binding with approximately 3 nM affinity to Semaphorin 4D (SEMA4D, CD100); an important mediator of axonal growth cone guidance,...
Autor:
Ernest S. Smith, Maurice Zauderer, Holm Bussler, Sebold Torno, Raymond Watkins, Terrence L. Fisher, John E. Leonard, Ji Li, Alan S. Jonason, Elizabeth E. Evans
Publikováno v:
Journal of Clinical Oncology. 28:e13154-e13154
e13154 Background: It has been demonstrated that semaphorin 4D (Sema4D; CD100) is a potent pro-angiogenic molecule. Sema4D binding to its receptor plexin-B1 (Plex-B1) on endothelial cells transacti...