Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Cornelia Liedtke"'
Autor:
Lajos Pusztai, Gabriel N. Hortobagyi, Bryan T. Hennessy, Massimo Cristofanilli, Chafika Mazouni, Fabrice Andre, Attila Tordai, W. Fraser Symmans, Cornelia Liedtke, Marjorie C. Green, Ana M. Gonzalez-Angulo, Kenneth R. Hess, Jaime A. Mejia
Publikováno v:
Journal of Clinical Oncology. 41:1809-1815
PURPOSE Triple-negative breast cancer (TNBC) is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression. In this study, we compared response to neoadjuvant chemotherap
Autor:
Rachel Würstlein, Friedrich Feuerhake, Bahriye Aktas, Ronald E. Kates, O Gluz, Cornelia Liedtke, C Hackmann, M Garke, H.H. Kreipe, EM Grischke, Claudia Schumacher, Nadia Harbeck, Matthias Christgen, S. Kuemmel, U Nitz, Helmut Forstbauer, Christoph Uleer, M Warm, Michael Braun
Publikováno v:
Journal of Clinical Oncology. 36:12102-12102
12102Background: In triple-negative breast cancer (TNBC), pathological complete response (pCR, ypT0/is/ypN0) is associated with improved prognosis. The randomized prospective WSG-ADAPT TN phase II ...
Autor:
Caroline Schweiger, Jens Uwe Blohmer, Karolin Fuchs, Olga Gorea, Jens Hoffmann, Guido Gambara, V Kiver, Ulrich Keilholz, MM Karsten, Philipp Jurmeister, Susen Burock, Bernadette Brzezicha, Cornelia Liedtke, Christian R. A. Regenbrecht, Nikola Bangemann, Carsten Denkert
Publikováno v:
Journal of Clinical Oncology. 36:12080-12080
12080Background: The establishment of patient-derived preclinical models in breast cancer has been a challenge for many years. We report our successful experience in establishing breast cancer pati...
Autor:
Michael Braun, Cornelia Liedtke, John Hackmann, Christoph Uleer, Nadia Harbeck, Matthias Christgen, Sherko Kümmel, Rachel Wuerstlein, Mathias Warm, Oleg Gluz, Helmut Forstbauer, Bahriye Aktas, Ronald E. Kates, Ulrike Nitz, Hans Kreipe, Eva-Maria Grischke, Claudia Schumacher, Christoph Lindner, Nikola Bangemann
Publikováno v:
Journal of Clinical Oncology. 36:573-573
573Background: Optimal chemotherapy in TNBC EBC is unclear. ADAPT TN demonstrated higher pCR (46% vs. 29%) and better safety for only 12 weeks nab-paclitaxel/carboplatin vs nab-paclitaxel/gemcitabine (JNCI 2017). Methods: Patients with centrally conf
Autor:
Thorsten Kühn, Sibylle Loibl, Cornelia Liedtke, Gisela Helms, Ingo Bauerfeind, Sabine Schmatloch, Barbara Fleige, Tanja Fehm, Gunter von Minckwitz, Hans-Christian Kolberg, Maik Hauschild, Peter Schrenk, Annette Lebeau, Annette Staebler, Michael Untch, Lukas Schwentner
Publikováno v:
Journal of Clinical Oncology. 36:559-559
559Background: The association between pathological complete remission (pCR) in the breast and clinical/pathological parameters is well established, whereas the association of clinical/pathological...
Autor:
Cornelia Liedtke, Sanne de Haas, Anke Kleine-Tebbe, Wolfram Malter, Michael Braun, Bahriye Aktas, Ronald E. Kates, Helmut Forstbauer, Regula Deurloo, Matthias Christgen, Nadia Harbeck, J. Tio, Ulrike Nitz, Rachel Wuerstlein, Hans Kreipe, Oleg Gluz, Doris Augustin, Sherko Kümmel, Claudia Schumacher, Jochem Potenberg
Publikováno v:
Journal of Clinical Oncology. 36:572-572
572Background: The ADAPT HER2+/HR+ phase II trial (NCT01745965) compared for the first time 12 wks. neoadjuvant T-DM1 (+/- endocrine therapy (ET)) with trastuzumab (T)+ET; pCR (ypT0/is ypN0) was > ...
Publikováno v:
Journal of Clinical Oncology. 36:e13119-e13119
e13119Background: Immunotherapy emerges to a promising concept for patients with Triple-Negative Breast Cancer (TNBC). Immune Checkpoint Inhibitors (ICI) are expressed by tumor tissue to evade the ...
Autor:
Sao Jiralerspong, Funda Meric-Bernstam, Shana L. Palla, Chad M. Barnett, Cornelia Liedtke, Limin Hsu, Sharon H. Giordano, Ana M. Gonzalez-Angulo, Gabriel N. Hortobagyi, Mien Chie Hung
Publikováno v:
Journal of Clinical Oncology. 27:3297-3302
Purpose Population studies have suggested that metformin use in diabetic patients decreases cancer incidence and mortality. Metformin inhibits the growth of cancer cells in vitro and tumors in vivo. However, there is little clinical data to support t
Autor:
Henry Mark Kuerer, Christos Sotiriou, Martine Piccart-Gebhart, Gabriel N. Hortobagyi, Christine Desmedt, Lajos Pusztai, Benjamin Haibe-Kains, Cornelia Liedtke, William Fraser Symmans, Christos Hatzis, Vicente Valero
Publikováno v:
Journal of Clinical Oncology. 27:3185-3191
Purpose The genomic grade index (GGI) is a 97-gene measure of histological tumor grade. High GGI is associated with decreased relapse-free survival in patients receiving either endocrine or no systemic adjuvant therapy. Herein we examined whether GGI
Autor:
Annette Staebler, Ingo Bauerfeind, Sabine Schmatloch, Tanja Fehm, Michael Untch, Barbara Fleige, Maik Hauschild, Hans-Christian Kolberg, Peter Schrenk, Lukas Schwentner, Annette Lebeau, Laura Kerschke, Dennis Goerlich, Cornelia Liedtke, Gunter von Minckwitz, Thorsten Kuehn, Sibylle Loibl, Gisela Helms
Publikováno v:
Journal of Clinical Oncology. 35:560-560
560 Background: Optimization of axillary staging in patients converting from cN+ to ycN0 through PST is needed. The aim of this analysis was to develop a nomogram predicting the probability of ypN+ after PST based on clinical/pathological parameters.