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Autor:
Celestia S. Higano
Publikováno v:
Journal of Clinical Oncology. 32:1107-1111
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33(24), 2585-2587. AMER SOC CLINICAL ONCOLOGY
In drug development and clinical trials, attention is paid not only to pharmacokinetic analysis of the drug, but increasingly to characteristics of the tumor, using techniques such as immunohistochemistry and genotyping. In the article that accompani
Autor:
Morie A. Gertz
Publikováno v:
Journal of Clinical Oncology. 33:537-539
In this issue of Journal of Clinical Oncology, Dimopoulos and thought leaders in the field of myeloma, representing the International Myeloma Working Group, provide evidence-based, consensus recommendations on the use of magnetic resonance imaging (M
Autor:
Richard Stone
Publikováno v:
Journal of Clinical Oncology. 31:1262-1266
A 42-year-old woman presented with bruising and fatigue. Her WBC count was 10,370/μL, with a differential showing 5% polys, 5% monos, 10% lymphocytes, and 80% myeloid-appearing blasts, some of which contained Auer rods (Fig 1). Bone marrow examinati
Autor:
Martine Piccart-Gebhart, Gabriel N. Hortobagyi, Richard L. Theriault, Ana M. Gonzalez-Angulo, D. Larsimont, Vicente Valero, Florentia Peintinger, Aysegul A. Sahin, Fatima Cardoso, Heidi Stranzl, Ronjay Rakkhit, Kristine Broglio, Donald A Berry, Emer O Hanrahan, Peter M. Ravdin, Merih Guray, Thomas A. Buchholz, Funda Meric-Bernstam, Jennifer K. Litton, Francesco Feoli
Publikováno v:
Journal of Clinical Oncology. 27:5700-5706
Purpose To evaluate the risk of recurrence in women diagnosed with T1a and T1b, node-negative, human epidermal growth factor receptor 2 (HER2) –positive breast cancer. Methods We reviewed 965 T1a,bN0M0 breast cancers diagnosed at our institution be
Autor:
Alessandra Cancellieri, Pasi A. Jänne, Luca Toschi, Fortunato Ciardiello, Marco Patelli, Stefania Bartolini, Alison J. Holmes, Rocco Trisolini, Elisa Rossi, Daniela Paioli, Elisabetta Magrini, C. Ligorio, Marileila Varella-Garcia, Federico Cappuzzo, Giovanna Finocchiaro, Lucio Crinò
Publikováno v:
Journal of Clinical Oncology. 25:2248-2255
Purpose In non–small-cell lung cancer (NSCLC), clinical and biologic predictors for epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor sensitivity have been identified in retrospective studies, and there is urgent need to validate th
Autor:
Luca Gianni, Gabriella Mariani, W. Fraser Symmans, Jenny Wu, Joffre B. Baker, Gabriel N. Hortobagyi, Jeffrey S. Ross, Milvia Zambetti, Roman Rouzier, Kim Clark, Jaime Rodriguez, Steven Shak, Drew Watson, Marialuisa Carcangiu, Maureen T. Cronin, Pinuccia Valagussa, Lajos Pusztai
Publikováno v:
Journal of Clinical Oncology. 23:7265-7277
Purpose We sought to identify gene expression markers that predict the likelihood of chemotherapy response. We also tested whether chemotherapy response is correlated with the 21-gene Recurrence Score assay that quantifies recurrence risk. Methods Pa
Autor:
Kelly Cox, Diane L. Persons, Jessica Tse, Ann D. Thor, Daniel F. Hayes, Debra B. Novotny, Dan R. Budman, I. Craig Henderson, Edison T. Liu, Hy Muss, Larry Norton, Lynn G. Dressler, Ashley Miller, Donald A. Berry, Maurice Barcos, Gloria Broadwater, David Cowan, Stephanie Griffin
Publikováno v:
Journal of Clinical Oncology. 23:4287-4297
Purpose HER2 is a clinically important tumor marker in breast cancer; however, there is controversy regarding which method reliably measures HER2 status. We compared three HER2 laboratory methods: immunohistochemistry (IHC), fluorescence in situ hybr
Autor:
Merrill J. Egorin, Steven R. Tahan, Jo Ann Proper, Glenn J. Bubley, Bruce J. Dezube, Thomas Miller, Henry B. Koon, Liron Pantanowitz, David Masiello, Pamela Chatis, Brad Smith, Will Weeden, Katherine Crosby
Publikováno v:
Journal of Clinical Oncology. 23:982-989
Purpose Activation of the platelet-derived growth factor (PDGF) and c-kit receptors has been proposed as important in mediating the growth of AIDS-related Kaposi's sarcoma (KS). We investigated the response of KS to the PDGF receptor (PDGFR)/c-kit in
Autor:
Volker Diehl, Lutz-Dietrich Leder, Rudolf Zankovich, Hans E. Schaefer, Annette Schmitt-Graeff, Juergen Thiele, Hans Michael Kvasnicka, Norbert Niederle
Publikováno v:
Journal of Clinical Oncology. 19:2994-3009
PURPOSE: Multivariate risk classifications for chronic (stable)-phase Ph1+ chronic myelogenous leukemia (CML) are generally focused on hematologic variables, and the putative prognostic property of bone morphology has been neglected or even contested