Zobrazeno 1 - 3
of 3
pro vyhledávání: '"35"'
Autor:
David M. Gershenson, Virginia Bayer, Neil S. Horowitz, Alexis Rabbit, Susana M. Campos, Shannon N. Westin, Lone Ottesen, Anil K. Sood, Pamela T. Soliman, Ying Yuan, Robert L. Coleman, Sobiya Tukdi, Alexi A. Wright, Panagiotis A. Konstantinopoulos, Gordon B. Mills, Robert Godin, Karen H. Lu, Charles F Levenback, Bryan Fellman, Joyce F. Liu
Publikováno v:
Journal of Clinical Oncology. 39:5505-5505
5505 Background: Wee1 phosphorylates and inhibits cyclin-dependent kinases 1 and 2 and is involved in regulation of the intra-S and G2/M cell cycle checkpoint arrest for premitotic DNA repair. The Wee1 inhibitor, adavosertib, has demonstrated activit
Autor:
Fan Jin, Roni Shapira, Ping Qiu, Mallika Sachdev Dhawan, Douglas A. Levine, Alexander Gozman, Timothy A. Yap, Taofeek K. Owonikoko, Andrew Eugene Hendifar, Miguel Quintela-Fandino, Michele Maio, Sanatan Saraf
Publikováno v:
Journal of Clinical Oncology. 38:TPS3156-TPS3156
TPS3156 Background: The anti-PD-1 antibody pembrolizumab (pembro) has improved clinical outcomes in multiple previously treated advanced solid tumors. The poly (ADP-ribose) polymerase (PARP) inhibitor olaparib (ola) has shown antitumor activity as mo
Autor:
Edward Chu, Ronald G. Stoller, Hussein Tawbi, Shannon Puhalla, Chandra P. Belani, Alice P. Chen, Leonard Joseph Appleman, Taofeek K. Owonikoko, R. Donald Harvey, Vincent L. Giranda, Stacie Peacock Shepherd, Yan Lin, Yixing Jiang, Brian F. Kiesel, Jan H. Beumer, Suresh S. Ramalingam, Athanassios Argiris, Sandra Strychor, Daniel P. Petro
Publikováno v:
Journal of Clinical Oncology. 30:3049-3049
3049 Background: Veliparib (ABT-888, NSC 737664) is an orally available inhibitor of poly(ADP-ribose) polymerase (PARP)-1 and -2: enzymes that recruit base excision repair machinery to single-stranded DNA breaks. Expression of PARP-1 may be increased