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Autor:
Yukiko Mori, Noriomi Matsumura, Atsushi Kawaguchi, Satoshi Morita, Ikuo Konishi, Ken Yamaguchi, Akihiko Ueda, Takafumi Ikeda, Akira Shimizu, Tsukasa Baba, Masaki Mandai, Shigemi Matsumoto, Shunsuke Chikuma, Masayuki Yokode, Toshinori Murayama, Junzo Hamanishi, Masashi Kanai, Kaoru Abiko, Yuko Hosoe, Manabu Minami, Tasuku Honjo
Publikováno v:
Journal of Clinical Oncology. 33:4015-4022
Purpose Programmed death-1 (PD-1), a coinhibitory immune signal receptor expressed in T cells, binds to PD-1 ligand and regulates antitumor immunity. Nivolumab is an anti–PD-1 antibody that blocks PD-1 signaling. We assessed the safety and antitumo
Autor:
Jiuzhou Wang, Eun Kyung Cho, David R. Spigel, Philip C. Hoffman, Julie D. Horan, Lucio Crinò, Sergey Orlov, Frances A. Shepherd, Joo Hang Kim, Mary O'Brien, Karen Kelly, Margaret A. Foley, Nasser K. Altorki, Piotr Serwatowski, Wilfried Eberhardt, C.-M. Tsai
Publikováno v:
Kelly, K; Altorki, NK; Eberhardt, WEE; OBrien, MER; Spigel, DR; Crinò, L; et al.(2015). Adjuvant erlotinib versus placebo in patients with stage IB-IIIA nonsmall-cell lung cancer (RADIANT): A randomized, double-blind, Phase III trial. Journal of Clinical Oncology, 33(34), 4007-4014. doi: 10.1200/JCO.2015.61.8918. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/2nv2v0wk
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 33, iss 34
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 33, iss 34
Purpose Epidermal growth factor receptor (EGFR) –tyrosine kinase inhibitors have proven efficacy in advanced non–small-cell lung cancer (NSCLC). We hypothesized that erlotinib would be efficacious in the adjuvant setting. Patients and Methods An
Autor:
Jennifer Zlott, Tomoko Freshwater, Khanh T. Do, Jerry M. Collins, Deborah Wilsker, Jiuping Ji, S. Kummar, James H. Doroshow, Robert J. Kinders, Alice P. Chen
Publikováno v:
Journal of Clinical Oncology. 33:3409-3415
Purpose Wee1 tyrosine kinase phosphorylates and inactivates cyclin-dependent kinase (Cdk) 1/2 in response to DNA damage. AZD1775 is a first-in-class inhibitor of Wee1 kinase with single-agent antitumor activity in preclinical models. We conducted a p
Autor:
Jennifer N. Uram, Andrea Wang-Gillam, Ed Lemmens, Dung T. Le, Justin Skoble, Deirdre Jill Cohen, Daniel A. Laheru, Beth Onners, Robert L. Fine, Todd S. Crocenzi, Michael A. Morse, John Grous, Tim F. Greten, Herbert J. Zeh, Thomas W. Dubensky, Dirk G. Brockstedt, Vincent J. Picozzi, Sara Solt, Gregory M. Springett, Aimee Murphy, Elizabeth M. Jaffee, Eric R. Lutz
Publikováno v:
Journal of Clinical Oncology. 33:1325-1333
Purpose GVAX pancreas, granulocyte-macrophage colony-stimulating factor–secreting allogeneic pancreatic tumor cells, induces T-cell immunity to cancer antigens, including mesothelin. GVAX is administered with low-dose cyclophosphamide (Cy) to inhib
Autor:
Dawen Sui, Anthony Lucci, Christopher W. Schacherer, Roland L. Bassett, Shenying Fang, Merrick I. Ross, Richard E. Royal, Yuling Wang, Huey Liu, Julie M. Gardner, Jeffrey E. Lee, Janice N. Cormier, John D. Reveille, Christopher I. Amos, Li E. Wang, Jeffrey E. Gershenwald, Qingyi Wei
Publikováno v:
Journal of Clinical Oncology. 33:1389-1396
Purpose To investigate the association between blood levels of C-reactive protein (CRP) in patients with melanoma and overall survival (OS), melanoma-specific survival (MSS), and disease-free survival. Patients and Methods Two independent sets of pla
Autor:
Tara Sanft, Brenda Cartmel, Elizabeth Ercolano, Scott Capozza, Maura Harrigan, Yang Zhou, Melinda L. Irwin, Tuhina Neogi, Marianna Rothbard, Fangyong Li, Jennifer A. Ligibel, Kathryn H. Schmitz, Cary P. Gross, Xiaopan Yao, Martha Fiellin, Dawn L. Hershman
Publikováno v:
Journal of Clinical Oncology. 33:1104-1111
Purpose Arthralgia occurs in up to 50% of breast cancer survivors treated with aromatase inhibitors (AIs) and is the most common reason for poor AI adherence. We conducted, in 121 breast cancer survivors receiving an AI and reporting arthralgia, a ye
Autor:
Xuehong Zhang, Shelley S. Tworoger, Bernard Rosner, Walter C. Willett, Jing Qian, Peter Kraft, A. Heather Eliassen, Susan E. Hankinson, Graham A. Colditz
Publikováno v:
Journal of Clinical Oncology. 32:3111-3117
Purpose Endogenous hormones are risk factors for postmenopausal breast cancer, and their measurement may improve our ability to identify high-risk women. Therefore, we evaluated whether inclusion of plasma estradiol, estrone, estrone sulfate, testost
Publikováno v:
Journal of Clinical Oncology. 32:1818-1824
Purpose Patients with Cowden syndrome (CS) with underlying germline PTEN mutations are at increased risk of breast, thyroid, endometrial, and renal cancers. To our knowledge, risk of subsequent cancers in these patients has not been previously explor
Integrative and Comparative Genomic Analysis of Lung Squamous Cell Carcinomas in East Asian Patients
Autor:
Young-Wook Kim, Andrey Sivachenko, Hong Kwan Kim, Gad Getz, Yeong Kyung Yoo, Jhingook Kim, Yoon-La Choi, Kyu Sik Kim, Yong Soo Choi, Jong Mu Sun, Michael S. Lawrence, Scott L. Carter, Keunchil Park, Chip Stewart, Matthew D. Wilkerson, Young Mog Shim, Petar Stojanov, Matthew Meyerson, Yoomi Lee, Kwhanmien Kim, Jin Seok Ahn, Sukki Cho, Jaegil Kim, D. Neil Hayes, Young-Chul Kim, Aaron McKenna, Sang Yun Song, Ji Ae Yoon, Myung-Ju Ahn, Kook Joo Na, Chandra Sekhar Pedamallu, Peter S. Hammerman, In-Jae Oh, Kristian Cibulskis
Publikováno v:
Journal of Clinical Oncology. 32:121-128
Purpose Lung squamous cell carcinoma (SCC) is the second most prevalent type of lung cancer. Currently, no targeted therapeutics are approved for treatment of this cancer, largely because of a lack of systematic understanding of the molecular pathoge
Autor:
Josenel Maria Barcelos Marçal, Bradley MacGregor, Mario Bernardes Wagner, Mateus W. De Bacco, André P. Fay, Guru Sonpavde, Gustavo F. Carvalhal
Publikováno v:
Journal of Clinical Oncology. 37:515-515
515 Background: Penile squamous cell carcinoma (PSCC) is a rare malignancy with limited treatment option in advanced stages. Brazil has one of the highest incidences of PSCC in the world, and different biology has been postulated across distinct popu