Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Margery A. Connelly"'
Autor:
Constantin L. Palm, Irina Shalaurova, Margery A. Connelly, Stephan J. L. Bakker, Berend Daan Westenbrink, Robin P. F. Dullaart
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 6, p 1541 (2024)
Background: Heart failure (HF) features a shift in metabolism towards enhanced utilization of ketone bodies. While elevations in plasma natriuretic peptides represent a biochemical hallmark of HF, natriuretic peptides may promote lipolysis, thereby c
Externí odkaz:
https://doaj.org/article/8db7effde43b426b9a93c4de05b1c26d
Autor:
Arno R. Bourgonje, Margery A. Connelly, Harry van Goor, Peter R. van Dijk, Robin P. F. Dullaart
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 20, p 6670 (2023)
Circulating citrate may represent a proxy of mitochondrial dysfunction which plays a role in the development of vascular complications in type 2 diabetes (T2D). Here, we determined the associations between plasma citrate levels and cardiovascular (CV
Externí odkaz:
https://doaj.org/article/7aae35305e9647288b661e7aa8e9e060
Autor:
Eline H. van den Berg, Jose L. Flores-Guerrero, Eke G. Gruppen, Erwin Garcia, Margery A. Connelly, Vincent E. de Meijer, Stephan J. L. Bakker, Hans Blokzijl, Robin P. F. Dullaart
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 5, p 1223 (2022)
Detailed information regarding lipoprotein concentrations and subfractions in cirrhotic patients before and after orthotopic liver transplantation (OLT) is lacking. Lipoprotein-Z (LP-Z) is a recently characterised abnormal, hepatotoxic free cholester
Externí odkaz:
https://doaj.org/article/9b39e5b802c24eba83b1e9f131a80804
Temporal Course of Plasma Trimethylamine N-Oxide (TMAO) Levels in ST-Elevation Myocardial Infarction
Autor:
Mohammad A. Almesned, Femke M. Prins, Erik Lipšic, Margery A. Connelly, Erwin Garcia, Robin P. F. Dullaart, Hilde E. Groot, Pim van der Harst
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 23, p 5677 (2021)
The gut metabolite trimethylamine N-oxide (TMAO) at admission has a prognostic value in ST-elevation myocardial infarction (STEMI) patients. However, its sequential changes and relationship with long-term infarct-related outcomes after primary percut
Externí odkaz:
https://doaj.org/article/eca08cea83e44c7d9eed457727c7a8c0
Autor:
Jose L. Flores-Guerrero, Peter R. van Dijk, Margery A. Connelly, Erwin Garcia, Henk J. G. Bilo, Gerjan Navis, Stephan J. L. Bakker, Robin P. F. Dullaart
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 11, p 2269 (2021)
Trimethylamine N-oxide (TMAO), a novel cardiovascular (CV) disease and mortality risk marker, is a gut microbiota-derived metabolite as well. Recently, plasma concentrations of branched-chain amino acids (BCAA) have been reported to be affected by mi
Externí odkaz:
https://doaj.org/article/613f883f60a14cd2bb60efee27a7e73c
Autor:
Shimpi Bedi, Erwin Garcia, Elias J. Jeyarajah, Irina Shalaurova, Maria Camila Perez-Matos, Z. Gordon Jiang, Robin P. F. Dullaart, Steven P. Matyus, William J. Kirk, James D. Otvos, W. Sean Davidson, Margery A. Connelly
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 9, p 2915 (2020)
Background: Lipoprotein particles with abnormal compositions, such as lipoprotein X (LP-X) and lipoprotein Z (LP-Z), have been described in cases of obstructive jaundice and cholestasis. The study objectives were to: (1) develop an NMR-based assay fo
Externí odkaz:
https://doaj.org/article/ebf0ee129af948d5ab22c632c3e3340d
Autor:
Jose L. Flores-Guerrero, Eke. G. Gruppen, Margery A. Connelly, Irina Shalaurova, James D. Otvos, Erwin Garcia, Stephan J. L. Bakker, Robin P. F. Dullaart
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 9, p 2781 (2020)
Objective: Evaluate the ability of a newly developed diabetes risk score, the Diabetes Risk Index (DRI), to predict incident type 2 diabetes mellitus (T2D) in a large adult population. Methods: The DRI was developed by combining the Lipoprotein Insul
Externí odkaz:
https://doaj.org/article/967347bc6bc04caea7200b5b708f64f4
Autor:
Maryse C. J. Osté, Jose L. Flores-Guerrero, Eke G. Gruppen, Lyanne M. Kieneker, Margery A. Connelly, James D. Otvos, Robin P. F. Dullaart, Stephan J. L. Bakker
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 2, p 511 (2020)
Post-transplant diabetes mellitus (PTDM) is a serious complication in renal transplant recipients. Branched-chain amino acids (BCAAs) are involved in the pathogenesis of insulin resistance. We determined the association of plasma BCAAs with PTDM and
Externí odkaz:
https://doaj.org/article/3aa1c28a7163488bb7db97f49b691914
Autor:
Erwin Garcia, Irina Shalaurova, Steven P. Matyus, David N. Oskardmay, James D. Otvos, Robin P.F. Dullaart, Margery A. Connelly
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 2, p 321 (2020)
Background: Quantifying mildly elevated ketone bodies is clinically and pathophysiologically relevant, especially in the context of disease states as well as for monitoring of various diets and exercise regimens. As an alternative assay for measuring
Externí odkaz:
https://doaj.org/article/3f012e37a92746d1bee258f32f13e469
Autor:
Peter R. van Dijk, Amaal Eman Abdulle, Marian L.C. Bulthuis, Frank G. Perton, Margery A. Connelly, Harry van Goor, Robin P.F. Dullaart
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 1, p 49 (2019)
Decreased circulating levels of free thiols (R-SH, sulfhydryl groups) reflect enhanced oxidative stress, which plays an important role in the pathogenesis of cardiometabolic diseases. Since hyperglycemia causes oxidative stress, we questioned whether
Externí odkaz:
https://doaj.org/article/9a5fae32540649e6b55a186aafabb49a