Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Roslyn B. Mannon"'
Publikováno v:
Journal of Clinical Investigation. 116:769-774
CD154 is a cell surface molecule expressed on activated T cells that binds to CD40, an activating molecule on APCs. Its blockade has been shown to prevent allograft rejection, presumably by interrupting interactions between T cells and APCs. It is kn
Autor:
Roslyn B. Mannon, Chandra Nataraj, Peter J. Mannon, Oliver Smithies, Laurent P. Audoly, Carmen S. Amuchastegui, Michael I. Oliverio, Thomas M. Coffman, Phillip Ruiz
Publikováno v:
Journal of Clinical Investigation. 104:1693-1701
The renin-angiotensin system (RAS) is a key regulator of vascular tone and blood pressure. In addition, angiotensin II also has a number of cellular effects that may contribute to disease pathogenesis. Using Agtr1a–/– mice, which lack AT1A recept
Autor:
Roslyn B. Mannon, Thomas M. Coffman, K. Ferri, Roger Kurlander, Chandra Nataraj, Brian L. Kotzin, Ellen Roper
Publikováno v:
Journal of Clinical Investigation. 101:2517-2527
Allospecific CD8(+) T lymphocytes are an important component of the cellular response in allograft rejection. These cells recognize and engage MHC class I antigens, leading to allospecific cytolytic responses and graft rejection. In mouse kidney allo