Zobrazeno 1 - 10
of 52
pro vyhledávání: '"11"'
Autor:
Matthew K. Siggins, Wafa Khamri, Thomas O’Connor, Evangelos Triantafyllou, Mark Thursz, Marie-Anne Mawhin, Mark J. W. McPhail, Hannah C. Husbyn, Kevin J. Woollard, Sujit Mukherjee, Marina Botto, Cathrin Gudd, Robert D. Goldin, Christine Bernsmeier, Charalambos G. Antoniades, Lucia A. Possamai, Francesca M. Trovato, Julia Wendon, Hiromi Kudo
Publikováno v:
The Journal of Clinical Investigation
Patients with acute liver failure (ALF) have systemic innate immune suppression and increased susceptibility to infections. Programmed cell death 1 (PD-1) expression by macrophages has been associated with immune suppression during sepsis and cancer.
Autor:
Jennifer R. Brown, Carl D. Novina, Tara M. Love, Victoria Del Gaizo Moore, Michael Certo, Anthony Letai
Publikováno v:
Journal of Clinical Investigation. 117:112-121
Antiapoptotic B cell leukemia/lymphoma 2 (BCL2) family proteins are expressed in many cancers, but the circumstances under which these proteins are necessary for tumor maintenance are poorly understood. We exploited a novel functional assay that uses
Autor:
Jean-François Rahier, M S Gross-Morand, Francis Brunelle, Jean-Marie Saudubray, V Foussier, Marie-Claire Brusset, Claire Nihoul-Fékété, J.-J. Robert, Claudine Junien, Jean-Paul Bonnefont, P de Lonlay, F. Poggi-Travert, J.-C. Fournet
Publikováno v:
Journal of Clinical Investigation, Vol. 100, no. 4, p. 802-807 (1997)
Sporadic persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or nesidioblastosis is a heterogeneous disorder characterized by profound hypoglycemia due to inappropriate hypersecretion of insulin. An important diagnostic goal is to distinguish
Autor:
Keiichi Ozono, Soji Kasayama, Takuya Yamamoto, Kosei Yoh, Shintaro Okada, Tadamitsu Kishimoto, Toshimi Michigami, M Takagi, Kanji Yamaoka, Sayuri Matsumoto, K Hiroshima
Publikováno v:
Journal of Clinical Investigation. 98:30-35
McCune-Albright syndrome (MAS) is characterized by café-au-lait spot, multiple endocrine hyperfunction, and polyostotic fibrous dysplasia. A somatic point mutation of Gsalpha protein was reported to decrease GTPase activity, leading to increase in t
Autor:
Andrew L. Snow, Kejian Zhang, Rebecca A. Marsh, Kim E. Nichols, Lisa R. Young, Jack van Hoff, Helen C. Su, Alexandra H. Filipovich, Michael J. Lenardo, Jack J. Bleesing, Philip A. Roehrs, Deepali Dhar, Scott M. Krummey
Publikováno v:
Journal of Clinical Investigation.
X-linked lymphoproliferative disease (XLP) is a rare congenital immunodeficiency that leads to an extreme, usually fatal increase in the number of lymphocytes upon infection with EBV. It is most commonly defined molecularly by loss of expression of S
Autor:
Stephen J. Haggarty, Roy H. Perlis, Jacob M. Hooker, Baileigh G. Hightower, Minhae Kim, Tonya M. Gilbert, Anisha Bhanot, Joshua L. Roffman, Marco L. Loggia, Hsiao-Ying Wey, Thomas M. Morin, Changning Wang, Frederick A. Schroeder, Daphne J. Holt, Daniel S. Albrecht, Kamber L. Hart, Nicole R. Zürcher, Steven M. Stufflebeam, Amelia M. Pellegrini, Hannah E. Brown, Misha M. Riley, Anais Rodriguez-Thompson, Christine J. Wu
Publikováno v:
Journal of Clinical Investigation. 129:364-372
BACKGROUND. Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the role of HDACs in cognitive disorders, including SCZ, remains unknown in huma
Autor:
Joyce Mulders, Marie van Dijk, Daoud Sie, Hari K. Thulluru, Ankie Poutsma, Gunilla Kleiverda, Omar J. Michel, Cees B.M. Oudejans, Augusta M. A. Lachmeijer, Sandra Windhorst
Publikováno v:
van Dijk, M, Thulluru, H K, Mulders, J, Michel, O J, Poutsma, A, Windhorst, S, Kleiverda, G, Sie, D L S, Lachmeijer, A M A & Oudejans, C B M 2012, ' HELLP babies link a novel lincRNA to the trophoblast cell cycle ', Journal of Clinical Investigation, vol. 122, no. 11, pp. 4003-4011 . https://doi.org/10.1172/JCI65171
Journal of Clinical Investigation, 122(11), 4003-4011. The American Society for Clinical Investigation
Journal of Clinical Investigation, 122(11), 4003-4011. The American Society for Clinical Investigation
The HELLP syndrome is a pregnancy-associated disease inducing hemolysis, elevated liver enzymes, and low platelets in the mother. Although the HELLP symptoms occur in the third trimester in the mother, the origin of the disease can be found in the fi
Autor:
Basil Rapoport, Gregorio D. Chazenbalk, J S Hutchison, Sandra M. McLachlan, Pui Seto, Stefano Portolano
Publikováno v:
Journal of Clinical Investigation. 90:720-726
To characterize the nature of thyroid peroxidase (TPO) autoantibodies present in the sera of patients with autoimmune thyroid disease, we cloned three IgG1/kappa Fab fragments which bind 125I-TPO. This was accomplished by the molecular cloning and ex
Autor:
Edward J. O'Keefe, Thomas A. Burke, Ramsey S. Labib, Grant J. Anhalt, Judith R. Oursler, Lina Ariss-Abdo
Publikováno v:
Journal of Clinical Investigation. 89:1775-1782
Recently, a previously unrecognized autoantibody mediated blistering disease, paraneoplastic pemphigus has been described. Paraneoplastic pemphigus is associated with lymphoid malignancies, thymomas, and poorly differentiated sarcomas. Serum of affec
Autor:
Lijun Kuang, Liyan Wen, Ling Sang, Rongchang Chen, Nanshan Zhong, Feng Ye, Yanjun Zhang, Jingxian Zhao, Xiaofang Huang, Zhao Chen, Airu Zhu, Jieling Liang, Abeer N. Alshukairi, Mian Gan, Haitao Tan, Yanqun Wang, Zhengtu Li, Manal M. Al Gethamy, Tie Song, Yongbo Huang, Jianfen Zhuo, Zhen Zhuang, Ling Luo, Shicong Ruan, Jincun Zhao, Min Li, Yimin Li, Jicheng Huang, J Wang, Lan Tang, Zhaoyong Zhang, Yimin Lin, Jing Sun, J. S. Malik Peiris, Chris Ka Pun Mok, Chunke Chen, Yongliang Jiang, Fang Li, Lu Zhang, Yuming Li, Bei Zhong, Stanley Perlman, Huibin Lv, Ying Deng
Publikováno v:
J Clin Invest
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for coronavirus 2019 (COVID-19) pneumonia. Little is known about the kinetics, tissue distribution, cross-reactivity, and neutralization antibody response in patients