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Publikováno v:
Journal of Clinical and Translational Science. 5:138-139
IMPACT: Our data identify a novel candidate for combination strategy in melanoma treatment, and can inform clinicians in their decision-making process regarding therapeutic intervention for melanoma patients. OBJECTIVES/GOALS: Soluble adenylyl cyclas
Autor:
Emma I. Brett, Kim Pulvers, Myra Rice, Eleanor L S Leavens, Nicole L. Nollen, Matthew S. Mayo, Jasjit S. Ahluwalia
Publikováno v:
Journal of Clinical and Translational Science. 5:85-86
IMPACT: This research suggests that African American and Latinx smokers who bear a disproportionate burden of tobacco-related harms are able to switch to e-cigarettes that present reduced harm to the user due to their similar reinforcement profile to
Autor:
Natalia A. Quijano Cardé, Bethany L. Stangl, Mariella De Biasi, Shyamala K. Venkatesh, Vijay A. Ramchandani
Publikováno v:
Journal of Clinical and Translational Science. 5:2-3
IMPACT: Understanding the influence of genetic variation and smoking on alcohol consumption helps in improving the treatment strategies for alcohol addiction OBJECTIVES/GOALS: Variation in the nicotinic receptor gene CHRNA5 (rs16969968) is associated
Publikováno v:
Journal of Clinical and Translational Science. 5:3-3
IMPACT: The first-line chemotherapies used to treat leishmaniasis are highly toxic intravenous antimonials yet drug resistance has begun to develop, causing the use of oral treatment options with high price tags; there is a strong need for new, safe,
Autor:
Zvezdana Zivorad Kojic
Publikováno v:
Journal of Clinical and Translational Science. 4:17-18
OBJECTIVES/GOALS: High cholesterol is among the major causes of cardiometabolic complications. People with high cholesterol have about twice the risk of heart disease as people with lower levels. Approximately every 40 seconds, an American will have
Autor:
Rebecca Selove, Maureen Sanderson, Karen Gilliam, William J. Blot, Rachel F. Tyndale, Hilary A. Tindle, Quiyin Cai, Nicole Senft, Suman Kundu
Publikováno v:
Journal of Clinical and Translational Science. 4:105-105
OBJECTIVES/GOALS: Precision care may engage smokers and providers in treatment but is understudied in the community. We piloted guideline-based care (GBC) alone or with Respiragene, a lung cancer polygenic risk score (PRS, 1-10), or metabolism-inform
Autor:
Jovia L. Nierenberg, Alexander C. Razavi, Xuenan Mi, Shengxu Li, Jiang He, Lydia A. Bazzano, Camilo Fernandez, Tanika N. Kelly
Publikováno v:
Journal of Clinical and Translational Science
OBJECTIVES/SPECIFIC AIMS: This population-based study aims to assess the individual and collective relationship between TMA-associated metabolites and echocardiographic parameters of left ventricular diastolic function. METHODS/STUDY POPULATION: The
Publikováno v:
Journal of Clinical and Translational Science
OBJECTIVES/SPECIFIC AIMS: Despite advancements in therapies, such as surgery, irradiation (IR) and chemotherapy, outcome for patients suffering from glioblastoma remains fatal; the median survival rate is only about 15 months. Even with novel therape
Autor:
Xin Lu
Publikováno v:
Journal of Clinical and Translational Science
OBJECTIVES/SPECIFIC AIMS: Prostate cancer (PCa) is the most common noncutaneous malignancy in men in the United States. A significant fraction of advanced PCa treated with androgen deprivation therapy experience relentless progression to lethal metas