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Autor:
Waleed H. Almalki, Rehan Abdur Rub, Kriti Soni, Majed Alrobaian, Fahad A. Al-Abbasi, Mahfoozur Rahman, Naushad Alam, Imran Kazmi, Manal A Alossaimi, Ozair Alam, Obaid Afzal, Sagar Suman Panda, Sarwar Beg
Publikováno v:
Journal of Chromatographic Science. 60:551-558
Neratinib, a tyrosine kinase inhibitor, was very recently approved by USFDA in 2017 as an anticancer drug to treat of HER2 positive breast cancers. The present work provides an account on the development of a validated bioanalytical UPLC–MS/MS meth
Publikováno v:
Journal of Chromatographic Science. 59:785-794
A simple, accurate, rapid and sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) method was established for determination of a novel non-vitamin K antagonist oral anticoagulant drug, betrixaban, and its co-administered calcium-
Autor:
Aline Correa Ribeiro, Jorge Willian Leandro Nascimento, Carlos Alberto Mourão-Júnior, Luciane Henriques Furtado Barroso, Julio Maria Fonseca Chebli
Publikováno v:
Journal of Chromatographic Science. 60:518-524
The conversion of azathioprine (AZA) to active 6-thioguanine nucleotides (6-TGN) is essential for its clinical efficacy; however, another metabolite formed, 6-methylmercaptopurine (6-MMP), is related to hepatotoxicity. Blood samples were collected fr
Publikováno v:
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Made available in DSpace on 2022-04-28T17:23:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-06-15 Ceftriaxone sodium is a widely used antimicrobial, which is only available as a lyophilized powder. The presence of methods for evaluating th
Autor:
Alptug Atila, Tugrul Cagri Akman, Mevlut Albayrak, Yucel Kadioglu, Mehmet Yaman, Zekai Halici
Publikováno v:
Journal of Chromatographic Science. 59:502-509
For the quantification of flurbiprofen in rat plasma, a simple UPLC-MS/MS method with high sensitivity and short retention time for flurbiprofen was developed and validated using specific parameters. Etodolac was used as internal standard. The transi
Publikováno v:
Journal of Chromatographic Science. 59:576-583
A high-performance thin-layer chromatographic method was developed and validated for the concurrent determination of simeprevir (SMV) and sofosbuvir (SOF). The chromatographic separation was attained on silica gel 60 F254 as stationary phase and ethy
Publikováno v:
Journal of Chromatographic Science. 59:521-525
A rapid, simple and sensitive liquid chromatography tandem mass spectrometry method for the determination of methohexital in human whole blood was developed and validated. Ethyl acetate/n-hexane (9:1) was used as extraction solvent while aprobarbital
Autor:
Gajanan G Kalyankar, Sandesh Lodha, Kunjan B Bodiwala, Shrikant V. Joshi, Pintu B Prajapati, Shailesh A. Shah, Prakruti N Desai, Ashish A Mishra
Publikováno v:
Journal of Chromatographic Science. 60:179-185
Pranlukast hydrate is an anti-asthmatic drug and used in the treatment of acute asthma. Stability-indicating RP-HPLC method for pranlukast hydrate has been developed and validated. The reverse phase high performance liquid chromatographic method was
Publikováno v:
Journal of Chromatographic Science. 59:510-520
Ticagrelor is recommended for management of patients with acute coronary syndromes. Green tea is one of the most popular beverages in China and around the world. Their concomitant use is unavoidable. In this study, a selective and sensitive liquid ch
Autor:
Krishnaveni Nagappan, S G Vasantharaju, Ramalingam Peraman, Pokuri Chiranjeevi, Yerrigamreddy Padmanabha Reddy, Kondreddy Vinod Kumar
Publikováno v:
Journal of Chromatographic Science. 59:899-908
In the present analytical approach, beta-alanine (ALA) and tris-(hydroxyl methyl) aminomethane (TRIS) were investigated as peak modifiers due to their water solubility and their possible peak modifying a property. These reagents were tested for their