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Autor:
Theoklis E. Zaoutis, Danielle M. Zerr, Rangaraj Selvarangan, Neena Kanwar, Christopher J. Harrison, Jason G. Newland, Dithi Banerjee, Xuan Qin
Publikováno v:
Journal of Chemotherapy. 33:288-293
Ceftolozane/tazobactam (C/T), a cephalosporin/beta-lactamase inhibitor combination, was evaluated in vitro vs. 10 comparators against 299 pediatric extended-spectrum-cephalosporin-resistant or carbapenem-resistant (ESC-R/CR) Gram-negative Enterobacte
Publikováno v:
Journal of Chemotherapy. 33:354-357
Pandrug-resistant A. baumannii (PDRAB) is increasingly being reported but remains rare. Several case studies show that A. baumannii can acquire resistance to last resort antibiotics during treatment by single-step chromosomal mutations. However, re-e
Autor:
Stamatis Karakonstantis
Publikováno v:
Journal of Chemotherapy. 33:1-11
The potential of A. baumannii for acquired resistance to last resort antibiotics (colistin and tigecycline) during treatment has important clinical implications, especially when dealing with patients failing to improve despite treatment with an activ
Autor:
Hamed Ebrahimzadeh Leylabadlo, Zainab Ahmadian, Reza Ghotaslou, Samin Alihosseini, Fatemah Sadeghpour Heravi
Publikováno v:
Journal of Chemotherapy. 32:273-285
Helicobacter pylori is a common gastric bacterial pathogen implicated in the pathogenesis of many digestive tract disorders. H. pylori infection prevalence has been reported alarmingly in Iran. A plethora of studies have been conducted to evaluate th
Autor:
Stephen H. Zinner, Elena N. Strukova, Svetlana A Dovzhenko, Alexander A. Firsov, Yury A. Portnoy, Maria V Golikova, Mikhail B Kobrin
Publikováno v:
Journal of Chemotherapy. 31:320-328
The search for optimal predictors of anti-mutant effects remains a pressing problem in studies of antibiotic-associated bacterial resistance. To relate the emergence of bacterial resistance with the antibiotic mutant prevention concentration (MPC), a
Publikováno v:
Journal of Chemotherapy. 31:195-201
Resistance to carbapenems in Enterobacteriaceae is a serious concern for public health. Alternative treatment options involving carbapenem-sparing regimen for patients with serious infections caused by multidrug-resistant Enterobacteriaceae are urgen
Autor:
Jesus Ruiz, Carmen Amaro, Paula Ramirez, Monica Gordon, Álvaro Castellanos-Ortega, Eva Sanjuán, Esther Villarreal
Publikováno v:
Journal of Chemotherapy. 31:202-208
Effective treatment approaches for biofilms in endotracheal tubes (ETTs) are lacking. In this study, we evaluated the in vitro effects of five antimicrobials against biofilms formed by Klebsiella pneumoniae in ETTs. K. pneumoniae was added to minimal
Autor:
Dianne Gardam, Peter Boan
Publikováno v:
Journal of Chemotherapy. 31:137-140
Candidemia is a common invasive fungal infection with a high mortality rate. We performed a retrospective audit of candidemia at a tertiary centre in Western Australia, 2005-2014. There were 167 episodes of candidemia due to 173 isolates of Candida.
Autor:
Maria Alicia Verzura, Esteban Gabriel Jauregui, Paula Scibona, María Guadalupe Pallotta, J.N. Minatta, Heidy Díaz de Arce, Carolina Vázquez, María Orlova, Waldo H. Belloso
Publikováno v:
Journal of Chemotherapy. 31:95-104
Pemetrexed is an antimetabolite approved for treatment of non-small cell lung cancer. Harbouring interindividual variability in both the pharmacokinetic and pharmacogenetic profiles may lead to life-threatening toxicities. A prospective cohort study
Autor:
Mary Jane Ferraro
Publikováno v:
Journal of Chemotherapy. 14:31-41
Fluoroquinolone antibiotics have been available since the 1980s when ciprofloxacin and norfloxacin were licensed. Structural revisions of the quinolone molecule have provided new compounds that were well suited to the treatment of upper and lower com