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Autor:
Jinghuan Fang, Michael Chopp, Li He, Li Zhang, Zheng Gang Zhang, Zhongwu Liu, William A. Golembieski, Fengjie Wang, Hongqi Xin
Publikováno v:
J Cereb Blood Flow Metab
Plasminogen is involved in the process of angiogenesis; however, the underlying mechanism is unclear. Here, we investigated the potential contribution of plasmin/plasminogen in mediating angiogenesis and thereby contributing to functional recovery po
Autor:
Agustin Liotta, Coline L. Lemale, Jens P. Dreier, Susanne Mueller, Svetlana Lublinsky, Alon Friedman, Philipp Boehm-Sturm, Majed Kikhia, Karl Schoknecht
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
Spreading depolarization (SD) and seizures are pathophysiological events associated with cerebral ischemia. Here, we investigated their role for injury progression in the cerebral cortex. Cerebral ischemia was induced in anesthetized male Wistar rats
Autor:
Yongjuan Fu, Mo Zhang, Xiaoduo He, Mohammed Hussain, Shengli Li, Cui Ma, Longfei Wu, Qi Yang, Yanhui Ma, Yong-Biao Zhang, Lipeng Cai, Yunxia Duan, Di Wu, Xinglong Zhi, Yuchuan Ding, Chuanjie Wu, Jingfei Shi, Chuanhui Li, Jian Chen, Tianqi Yao, Feng Yan, Ming Song, Zixin Zhu, Xunming Ji, Chunxiu Wang
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
Nearly all stroke neuroprotection modalities, including selective intra-arterial cooling (SI-AC), have failed to be translated from bench to bed side. Potentially overlooked reasons may be biological gaps, inadequate attention to reperfusion states a
Publikováno v:
J Cereb Blood Flow Metab
There is increasing evidence that widespread cortical cerebral blood flow deficits occur early in the course of Parkinson’s disease. Although cerebral blood flow measurement has been suggested as a potential biomarker for early diagnosis of Parkins
Autor:
Steven G. Kernie, Changhee Lee, Patricia M. Washington, Barclay Morrison, Mary Kate R Dwyer, Elisa E. Konofagou
Publikováno v:
J Cereb Blood Flow Metab
Cerebral edema and the subsequent increased intracranial pressure are associated with mortality and poor outcome following traumatic brain injury. Previous in vitro studies have shown that the Gibbs-Donnan effect, which describes the tendency of a po
Autor:
Ge Li, Yue Lan, Cheng Wu, Xiao-fei He, Yu Zhang, Yi-xuan Zeng, Guang-qing Xu, Fengyin Liang, Yukun Feng, Zhong Pei
Publikováno v:
J Cereb Blood Flow Metab
Using a photothrombotic mouse model of single stroke, we show that a single stroke onset increases the nuclear factor-κB (NF-κB), NLR family CARD domain containing protein 4 (NLRC4), and absent in melanoma 2 (AIM2) inflammasomes, as well as the mRN
Publikováno v:
J Cereb Blood Flow Metab
Hydrocephalus has been reported to occur in spontaneous hypertensive rats (SHRs). The purposes of this study were (1) to use T2 magnetic resonance imaging to examine time of onset, (2) to elucidate potential underlying mechanisms and (3) to determine
Autor:
Geir Ringstad, Per Kristian Eide
Publikováno v:
J Cereb Blood Flow Metab
The glymphatic system plays a key role for clearance of waste solutes from the rodent brain. We recently found evidence of glymphatic circulation in the human brain when using magnetic resonance imaging (MRI) contrast agent as cerebrospinal fluid (CS
Autor:
David R. Jacobs, Reto Auer, Martine Elbejjani, Christos Davatzikos, John A. Detre, Lenore J. Launer, Thaddeus J. Haight, David C. Goff, R. Nick Bryan, Sudipto Dolui
Publikováno v:
J Cereb Blood Flow Metab
Cigarette smoking is often associated with dementia. This association is thought to be mediated by hypoperfusion; however, how smoking behavior relates to cerebral blood flow (CBF) remains unclear. Using data from the Coronary Artery Risk Development
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 37:3110-3123
Iron overload plays a key role in the secondary brain damage that develops after intracerebral hemorrhage (ICH). The significant increase in iron deposition is associated with the generation of reactive oxygen species (ROS), which leads to oxidative