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Publikováno v:
Journal of Cellular Biochemistry. 105:313-320
Placenta growth factor (PlGF) is a member of the VEGF family and has been implicated in the aggressive capacity of solid tumours, partly via its impact on angiogenesis. The present study determined the direct biological function of endogenous PlGF in
Publikováno v:
Journal of Cellular Biochemistry. 104:1054-1064
Ouabain is Na(+)/K(+)-ATPase inhibitor and an endogenous regulator of blood pressure, it has dual effect on vascular endothelial cells(VEC) cell growth and VEC apoptosis is contributed to vascular dysfunction involved in vascular remolding. However,
Publikováno v:
Journal of Cellular Biochemistry. 102:759-768
Although the critical role of M-CSF in osteoclastogenesis is well documented, there has been no detailed analysis of how it regulates human osteoclast formation and function in vitro. We used a human osteoclastogenesis model employing CFU-GM osteocla
Autor:
Yong J. Lee, Young-Ho Kim
Publikováno v:
Journal of Cellular Biochemistry. 100:998-1009
TNF-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapy that preferentially induces apoptosis in cancer cells. However, many neoplasms are resistant to TRAIL by mechanisms that are poorly understood. Here we demonstrated that huma
Publikováno v:
Journal of Cellular Biochemistry. 100:1573-1580
We study the effect of fungal-derived chitosan on the development of chemical-induced colonic precancerous lesions in ICR mice and delineate its possible molecular mechanisms. In the 2 weeks preventive experiments, mice fed with a diet containing hig
Publikováno v:
Journal of Cellular Biochemistry. 100:174-183
Several studies indicate that progesterone exerts relevant effects in breast tissue. However, the exact role of this steroid in breast cancer development and progression has not been elucidated. Here, we show that platelet-derived growth factor (PDGF
Autor:
Humphrey Hodgson, Clare Selden, Sam Coward, Michael Kirwan, Peter Collins, Leonard H. Damelin
Publikováno v:
Journal of Cellular Biochemistry. 101:723-734
The mechanisms by which steatosis renders hepatocytes susceptible to damage in non-alcoholic steatohepatitis (NASH) are unclear although fat accumulation is believed to increase hepatocyte susceptibility to inflammatory cytokines and oxidative stress
Publikováno v:
Journal of Cellular Biochemistry. 102:689-703
Cellular life-span of neonatal human brain microvascular endotheliocytes (HBME) was estimated by population doubling levels (PDLs) for serial subcultivations until spontaneous proliferation stoppage, and was 2.4-fold longer for continuous administrat
Autor:
Paula H. Stern
Publikováno v:
Journal of Cellular Biochemistry. 101:1087-1096
Antiresorptive agents have proven to be effective therapies for the treatment of bone diseases associated with excessive osteoclast activity. Decreased osteoclast formation, inhibition of osteoclast actions, and reduced osteoclast survival represent
Publikováno v:
Journal of Cellular Biochemistry. 101:1520-1531
During inflammation, overproduction of nitric oxide (NO) can damage chondrocytes. In this study, we separately evaluated the toxic effects of exogenous and endogenous NO on human chondrocytes and their possible mechanisms. Human chondrocytes were exp