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BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple‐negative breast cancer cells
Publikováno v:
Journal of Cellular Biochemistry. 123:77-90
By regulating several hallmarks of cancer, BAG3 exerts oncogenic functions in a wide variety of malignant diseases including glioblastoma (GBM) and triple-negative breast cancer (TNBC). Here we performed global proteomic/phosphoproteomic analyses of
Autor:
Jessica Oyie Sousa Onyeisi, Martin Götte, Ludwig Kiesel, Nancy Adriana Espinoza-Sánchez, Burkhard Greve, Carla Cristina Lopes
Publikováno v:
Journal of Cellular Biochemistry. 122:1491-1505
Syndecan-4, a predicted target of the microRNA miR-140-3p, plays an important role in multiple steps of tumor progression and is the second most abundant heparan sulfate proteoglycan produced by breast carcinoma cell lines. To investigate the potenti
Autor:
Farah Anjum, Imtaiyaz Hassan, Alaa Shafie, Faizan Ahmad, Asimul Islam, Anas Shamsi, Saleha Anwar, Shama Khan
Publikováno v:
Journal of Cellular Biochemistry. 122:1445-1459
MAP/microtubule affinity-regulating kinase 4 (MARK4) is a member of serine/threonine kinase family and considered an attractive drug target for many diseases. Screening of Indian Medicinal Plants, Phytochemistry, and Therapeutics (IMPPAT) using virtu
Autor:
Ann B. Moser, Nancy Braverman, Yanqiu Liu, Ali Fatemi, Shandi Hiebler, Ulrike Schrifl, Paul A. Watkins, Xiaohai Shi, Steven J. Steinberg
Publikováno v:
J Cell Biochem
X-linked adrenoleukodystrophy (XALD) is a genetic neurologic disorder with multiple phenotypic presentations and limited therapeutic options. The childhood cerebral phenotype (CCALD), a fatal demyelinating disorder affecting about 35% of patients, an
Autor:
Ming-Cheng Chen, Liang-Yo Yang, Chi-Cheng Li, B Mahalakshmi, Tsung-Jung Ho, Do Chi Nhan, Tso-Fu Wang, Chiung-Hung Hsu, Chih Yang Huang, Mei-Chih Chen
Publikováno v:
Journal of Cellular Biochemistry. 122:1277-1294
Colorectal cancer is one of the most prevalent cancers in the world. Chemoresistance has always been a problem encountered in its treatment. It is known that SUMOylation may regulate protein stability and decomposition, and even affect the protein tr
Publikováno v:
Journal of Cellular Biochemistry
WNT5A activates noncanonical Wnt signaling pathways and has critical functions in early development, differentiation, and tissue homeostasis. Two major WNT5A protein isoforms, which in this study we term WNT5A‐L(A) and WNT5A‐S(B), have been ident
Publikováno v:
Journal of Cellular Biochemistry. 122:1302-1312
Although dysregulation and dysfunction of long noncoding RNAs (lncRNAs) have been implicated in malignant behavior of oral squamous cell carcinoma (OSCC), whether aberrant lncRNAs play a role in the carcinogenesis of oral leukoplakia (OL) as the best
Autor:
Christian Behl, Marius W. Baeken
Publikováno v:
Journal of Cellular Biochemistry. 123:102-114
The B-cell CLL 2-associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence and d
Autor:
Van T. Hoang, Jacqueline La, Brian G. Rowan, Saloni Patel, Aaron Buechlein, Matthew E. Burow, Bridgette M. Collins-Burow, Margarite D. Matossian, Lucio Miele, Douglas B. Rusch, Akshita B. Bhatt, Murali Anbalagan, Douglas B. Chrisey, Thomas D. Wright, Jane E. Cavanaugh, Kristine Hoang, Steven Elliott, Patrick T. Flaherty, Kenneth P. Nephew, Deniz A. Ucar, Theresa B. Phamduy, Hope E. Burks
Publikováno v:
Journal of Cellular Biochemistry. 122:835-850
Triple-negative breast cancer (TNBC) presents a clinical challenge due to the aggressive nature of the disease and a lack of targeted therapies. Constitutive activation of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kin
Publikováno v:
J Cell Biochem
G protein-coupled receptors regulate a variety of cellular responses and have been considered as therapeutic targets for human diseases. Lysophosphatidic acid receptor 1 (LPA1) is a receptor for bioactive lysophospholipid, LPA. LPA/LPA1-mediated sign