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Autor:
Ann B. Moser, Nancy Braverman, Yanqiu Liu, Ali Fatemi, Shandi Hiebler, Ulrike Schrifl, Paul A. Watkins, Xiaohai Shi, Steven J. Steinberg
Publikováno v:
J Cell Biochem
X-linked adrenoleukodystrophy (XALD) is a genetic neurologic disorder with multiple phenotypic presentations and limited therapeutic options. The childhood cerebral phenotype (CCALD), a fatal demyelinating disorder affecting about 35% of patients, an
Autor:
Ming-Cheng Chen, Liang-Yo Yang, Chi-Cheng Li, B Mahalakshmi, Tsung-Jung Ho, Do Chi Nhan, Tso-Fu Wang, Chiung-Hung Hsu, Chih Yang Huang, Mei-Chih Chen
Publikováno v:
Journal of Cellular Biochemistry. 122:1277-1294
Colorectal cancer is one of the most prevalent cancers in the world. Chemoresistance has always been a problem encountered in its treatment. It is known that SUMOylation may regulate protein stability and decomposition, and even affect the protein tr
Publikováno v:
J Cell Biochem
G protein-coupled receptors regulate a variety of cellular responses and have been considered as therapeutic targets for human diseases. Lysophosphatidic acid receptor 1 (LPA1) is a receptor for bioactive lysophospholipid, LPA. LPA/LPA1-mediated sign
Publikováno v:
Journal of Cellular Biochemistry. 122:305-314
Multiple myeloma (MM) is a malignant neoplasm featured by obvious drug resistance and poor prognosis. MicroRNAs (miRNAs) are a class of small noncoding RNAs with crucial roles in many biological processes including cancer initiation and progression.
Publikováno v:
Journal of Cellular Biochemistry. 122:394-402
Epidermal growth factor receptor (EGFR) induces peroxisome-proliferator-activated receptor-δ (PPARδ)-Y108 phosphorylation, while it is unclear the effect of phosphorylation of PPARδ on cancer cell metabolism. Here we found that EGF treatment incre
Publikováno v:
Journal of Cellular Biochemistry. 122:153-165
Doxorubicin (DOX) is a boon for cancer-suffering patients. However, the undesirable effect on health on vital organs, especially the heart, is a limiting factor, resulting in an increased number of patients with cardiac dysfunction. The present revie
Publikováno v:
Journal of Cellular Biochemistry. 121:4450-4457
The mechanisms driving the pathologic progression of osteoarthritis (OA) have not yet to be fully elucidated. Excessive and irreversible breakdown of the extracellular matrix is the main hallmark of OA. Inhibitors of DPP-4 have been widely used for o
Publikováno v:
Journal of Cellular Biochemistry. 121:3584-3592
Cisplatin is one of the conventional drugs used in chemotherapy which has a potent antitumor function. However, due to the dangerous side effects, including the damage to DNA of the normal cells, its clinical use is limited. The aim of this study was
Publikováno v:
Journal of Cellular Biochemistry. 121:2730-2738
Leukemia or cancer of blood is a well-known cancer, which affects a range of people from newborns to the very old. It is a public health problem throughout the world. By way of treatment, due to the lack of specific anticancer therapies, common treat
Publikováno v:
Journal of Cellular Biochemistry. 121:2225-2235
Purpose Long-chain noncoding RNAs (lncRNAs) are involved in regulating the sensitivity of cancer cells to chemotherapeutic drugs, but the specific mechanism of action is not well understood. The aim of this study was to investigate the effect of lncR