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Autor:
Ann B. Moser, Nancy Braverman, Yanqiu Liu, Ali Fatemi, Shandi Hiebler, Ulrike Schrifl, Paul A. Watkins, Xiaohai Shi, Steven J. Steinberg
Publikováno v:
J Cell Biochem
X-linked adrenoleukodystrophy (XALD) is a genetic neurologic disorder with multiple phenotypic presentations and limited therapeutic options. The childhood cerebral phenotype (CCALD), a fatal demyelinating disorder affecting about 35% of patients, an
Publikováno v:
Journal of Cellular Biochemistry
WNT5A activates noncanonical Wnt signaling pathways and has critical functions in early development, differentiation, and tissue homeostasis. Two major WNT5A protein isoforms, which in this study we term WNT5A‐L(A) and WNT5A‐S(B), have been ident
Autor:
Christian Behl, Marius W. Baeken
Publikováno v:
Journal of Cellular Biochemistry. 123:102-114
The B-cell CLL 2-associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence and d
Publikováno v:
J Cell Biochem
G protein-coupled receptors regulate a variety of cellular responses and have been considered as therapeutic targets for human diseases. Lysophosphatidic acid receptor 1 (LPA1) is a receptor for bioactive lysophospholipid, LPA. LPA/LPA1-mediated sign
Publikováno v:
Journal of Cellular Biochemistry. 122:760-769
As nano-level information carriers, extracellular vesicles (EVs) contain proteins, DNA or RNA, which maintain the transmembrane transport of biomolecules and the homeostasis of normal cells. EVs can be released by most cell types and absorbed by spec
Autor:
Hongsheng Liu, Yeye Chen, Cheng Huang, Xiaoyun Zhou, Zhenhuan Tian, Yingzhi Qin, Li Li, Jia He
Publikováno v:
Journal of Cellular Biochemistry. 122:315-325
It has been demonstrated in previous studies that lncPART1 is dysregulated in non-small cell lung cancer (NSCLC). However, the function of lncPART1 in NSCLC is unclear. Therefore, this experimental design was based on LncPART1 to explore the pathogen
Publikováno v:
Journal of Cellular Biochemistry. 122:403-412
Acute myeloid leukaemia (AML) is a blood cancer where undifferentiated myeloid cells are increased in the bone marrow and peripheral blood. As AML is dangerous and shows poor prognosis, many researchers categorised the relevant cytogenetic factors ac
Autor:
Kazuaki Miyagawa, Theresa A. Guise, Khalid S. Mohammad, Noriyoshi Kurihara, Daniela N. Petrusca, Jolene J. Windle, Yuki Nagata, Yasuhisa Ohata, G. David Roodman, Gabriel M. Pagnotti
Publikováno v:
Journal of Cellular Biochemistry
Paget's disease (PD) is characterized by increased numbers of abnormal osteoclasts (OCLs) that drive exuberant bone formation, but the mechanisms responsible for the increased bone formation remain unclear. We previously reported that OCLs from 70% o
Publikováno v:
Journal of Cellular Biochemistry. 122:153-165
Doxorubicin (DOX) is a boon for cancer-suffering patients. However, the undesirable effect on health on vital organs, especially the heart, is a limiting factor, resulting in an increased number of patients with cardiac dysfunction. The present revie
Publikováno v:
Journal of Cellular Biochemistry. 121:3266-3277
Bone morphogenetic proteins regulate a diverse range of biological processes through their activation of SMAD1, SMAD5, or SMAD8 proteins that, in turn, regulate gene expression. These SMAD transcription factors achieve a layer of functional specifici