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Autor:
Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, Juan Zhao, Madison Schank, Xindi Dang, Dechao Cao, Sushant Khanal, Xiao Y. Wu, Yi Zhang, Jinyu Zhang, Shunbin Ning, Ling Wang, Mohamed El Gazzar, Jonathan P. Moorman, Zhi Q. Yao
Publikováno v:
J Cell Sci
We investigated the role of telomerase and telomere repeat-binding factor 2 (TRF2 or TERF2) in T-cell dysfunction in chronic viral infection. We found that the expression and activity of telomerase in CD4+ T (CD4T) cells from patients with hepatitis
Publikováno v:
J Cell Sci
We have previously demonstrated significant upregulation of dopamine D2 (DAD2) receptor (DRD2) expression on tumor endothelial cells. The dopamine D2 receptors, upon activation, inhibit the proangiogenic actions of vascular endothelial growth factor-
Publikováno v:
J Cell Sci
Polycystins are conserved mechanosensitive channels whose mutations lead to the common human renal disorder autosomal dominant polycystic kidney disease (ADPKD). Previously, we discovered that the plasma membrane-localized fission yeast polycystin ho
Autor:
Jessica L. Cote, Paul B. Vander, Michael Ellis, Joel M. Cline, Nadezhda Svezhova, Michael E. Doche, Travis J. Maures, Tahrim A. Choudhury, Seongbae Kong, Olivia G. J. Klaft, Ray M. Joe, Lawrence S. Argetsinger, Christin Carter-Su
Publikováno v:
J Cell Sci
The adapter protein SH2B1 is recruited to neurotrophin receptors, including TrkB (also known as NTRK2), the receptor for brain-derived neurotrophic factor (BDNF). Herein, we demonstrate that the four alternatively spliced isoforms of SH2B1 (SH2B1α
Publikováno v:
J Cell Sci
Integrin α6β4 binds plectin to associate with vimentin; however, the biological function remains unclear. Here, we utilized various integrin β4 mutants and CRISPR-Cas9 editing to investigate this association. Upon laminin binding, integrin α6β4
Autor:
Auriane C Ernault, Ingeborg van der Made, Simona Casini, Simona Aufiero, Pablo Montañés-Agudo, Carol Ann Remme, Yigal M. Pinto, Esther E. Creemers
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
Journal of cell science, 135(1):jcs259191. Company of Biologists Ltd
article-version (VoR) Version of Record
Journal of cell science, 135(1):jcs259191. Company of Biologists Ltd
Eukaryotic genomes contain a tiny subset of ‘minor class’ introns with unique sequence elements that require their own splicing machinery. These minor introns are present in certain gene families with specific functions, such as voltage-gated Na+
Autor:
Devon Cogswell, Mei Sun, Yasmin Ayoubi, Ambuj Kumar, Marcel Y. Avila, Curtis E. Margo, Edgar M. Espana, Tea Reljic, Sheila M. Adams
Publikováno v:
J Cell Sci
Collagen XI plays a role in nucleating collagen fibrils and in controlling fibril diameter. The aim of this research was to elucidate the role that collagen XI plays in corneal fibrillogenesis during development and following injury. The temporal and
Autor:
Neil A. R. Gow, Filomena Nogueira, Alessandra da Silva Dantas, Megan D. Lenardon, Louise A. Walker, Keunsook K. Lee, Alexandra C. Brand, Matt Edmondson
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Echinocandins such as caspofungin are frontline antifungal drugs that compromise β-1,3 glucan synthesis in the cell wall. Recent reports have shown that fungal cells can resist killing by caspofungin by upregulation of chitin synthesis, thereby sust
Autor:
Marika Meyer zu Brickwedde, Dietmar Vestweber, Giuseppe Trapani, Ute Ipe, Hans R. Schöler, Laura J Braun, Hermann vom Bruch, Britta Trappmann, Martina Schmitt, Stephan Huveneers, Mirsana P. Ebrahimkutty, Noboru Ishiyama, Cao Nguyen Duong, Johan de Rooij, Astrid F. Nottebaum, Mitsuhiko Ikura, Randy Brückner
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
Journal of cell science, 134(24). Company of Biologists Ltd
article-version (VoR) Version of Record
Journal of cell science, 134(24). Company of Biologists Ltd
Cadherin-mediated cell adhesion requires anchoring via the β-catenin–α-catenin complex to the actin cytoskeleton, yet, α-catenin only binds F-actin weakly. A covalent fusion of VE-cadherin to α-catenin enhances actin anchorage in endothelial ce
Autor:
Zhi-Xiong Jim Xiao, Simone Baldan, Anatoli B. Meriin, Michael Y. Sherman, Julia Yaglom, Xaralabos Varelas, Ilya Alexandrov
Publikováno v:
J Cell Sci
Protein abnormalities can accelerate aging causing protein misfolding diseases, and various adaptive responses have evolved to relieve proteotoxicity. To trigger these responses, cells must detect the buildup of aberrant proteins. Previously we demon