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Autor:
Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, Juan Zhao, Madison Schank, Xindi Dang, Dechao Cao, Sushant Khanal, Xiao Y. Wu, Yi Zhang, Jinyu Zhang, Shunbin Ning, Ling Wang, Mohamed El Gazzar, Jonathan P. Moorman, Zhi Q. Yao
Publikováno v:
J Cell Sci
We investigated the role of telomerase and telomere repeat-binding factor 2 (TRF2 or TERF2) in T-cell dysfunction in chronic viral infection. We found that the expression and activity of telomerase in CD4+ T (CD4T) cells from patients with hepatitis
Publikováno v:
J Cell Sci
We have previously demonstrated significant upregulation of dopamine D2 (DAD2) receptor (DRD2) expression on tumor endothelial cells. The dopamine D2 receptors, upon activation, inhibit the proangiogenic actions of vascular endothelial growth factor-
Publikováno v:
J Cell Sci
Polycystins are conserved mechanosensitive channels whose mutations lead to the common human renal disorder autosomal dominant polycystic kidney disease (ADPKD). Previously, we discovered that the plasma membrane-localized fission yeast polycystin ho
Publikováno v:
J Cell Sci
Integrin α6β4 binds plectin to associate with vimentin; however, the biological function remains unclear. Here, we utilized various integrin β4 mutants and CRISPR-Cas9 editing to investigate this association. Upon laminin binding, integrin α6β4
Autor:
Neil A. R. Gow, Filomena Nogueira, Alessandra da Silva Dantas, Megan D. Lenardon, Louise A. Walker, Keunsook K. Lee, Alexandra C. Brand, Matt Edmondson
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Echinocandins such as caspofungin are frontline antifungal drugs that compromise β-1,3 glucan synthesis in the cell wall. Recent reports have shown that fungal cells can resist killing by caspofungin by upregulation of chitin synthesis, thereby sust
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Centromeres are chromosomal regions that serve as sites for kinetochore formation and microtubule attachment, processes that are essential for chromosome segregation during mitosis. Centromeres are almost universally defined by the histone variant CE
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The WAVE regulatory complex (WRC) is the main activator of the Arp2/3 complex, promoting lamellipodial protrusions in migrating cells. The WRC is basally inactive but can be activated by Rac1 and phospholipids, and through phosphorylation. However, t
Autor:
Shinya Tashiro, Chie Motono, Kenichiro Imai, Waka Kojima, Kouhei Tsumoto, Mayumi Kimura, Jose M. M. Caaveiro, Noriyuki Matsuda, Chisato Udagawa, Bruno B. Queliconi, Takatsugu Hirokawa, Keiji Tanaka, Koji Yamano
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Diverse genes associated with familial Parkinson's disease (familial Parkinsonism) have been implicated in mitochondrial quality control. One such gene, PARK7 encodes the protein DJ-1, pathogenic mutations of which trigger its translocation from the
Autor:
Christopher M. Hammell, Françoise Schwager, Alexandra Bondaz, Jing Wang, Monica Gotta, Simona Abbatemarco
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
Journal of cell science, Vol. 134, No 22 (2021) P. jcs258834
article-version (VoR) Version of Record
Journal of cell science, Vol. 134, No 22 (2021) P. jcs258834
When exposed to stressful conditions, eukaryotic cells respond by inducing the formation of cytoplasmic ribonucleoprotein complexes called stress granules. Here, we use C. elegans to study two proteins that are important for stress granule assembly i
Autor:
Daniela Nicastro, Kai Cai, Lei Zhao, George B. Witman, Yuqing Hou, Yanhe Zhao, Nhan Phan, Xi Cheng
Publikováno v:
J Cell Sci
Motile cilia have a ‘9+2’ structure containing nine doublet microtubules and a central apparatus (CA) composed of two singlet microtubules with associated projections. The CA plays crucial roles in regulating ciliary motility. Defects in CA assem