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Publikováno v:
Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2019, 132 (24), pp.jcs230995. ⟨10.1242/jcs.230995⟩
Journal of Cell Science, Company of Biologists, 2019, 132 (24), pp.jcs230995. ⟨10.1242/jcs.230995⟩
Many studies have investigated the processes that support polarity establishment and maintenance in cells. On the one hand, polarity complexes at the cell cortex and their downstream signaling pathways have been assigned as major regulators of polari
Publikováno v:
Journal of cell science. 132(23)
The transcription factor Snai2, encoded by the SNAI2 gene, is an evolutionarily conserved C2H2 zinc finger protein that orchestrates biological processes critical to tissue development and tumorigenesis. Initially characterized as a prototypical epit
Autor:
Ling Qi, Asmita Bhattacharya
Publikováno v:
J Cell Sci
The recent literature has revolutionized our view on the vital importance of endoplasmic reticulum (ER)-associated degradation (ERAD) in health and disease. Suppressor/enhancer of Lin-12-like (Sel1L)–HMG-coA reductase degradation protein 1 (Hrd1)-m
Autor:
Rudolf Winklbauer
Publikováno v:
Journal of Cell Science. 132
Cell–cell adhesion strength, measured as tissue surface tension, spans an enormous 1000-fold range when different cell types are compared. However, the examination of basic mechanical principles of cell adhesion indicates that cadherin-based and re
Autor:
Peter Satir, Birgit H. Satir
Publikováno v:
Journal of Cell Science. 132
Many signaling molecules are localized to both the primary cilium and nucleus. Localization of specific transmembrane receptors and their signaling scaffold molecules in the cilium is necessary for correct physiological function. After a specific sig
Publikováno v:
Journal of Cell Science. 129:3067-3076
The pleated septate junction (pSJ), an ancient structure for cell–cell contact in invertebrate epithelia, has protein components that are found in three more-recent junctional structures, the neuronal synapse, the paranodal region of the myelinated
Autor:
Hananel Aharon, Aryeh Babkoff, Daniel Ronen, Einav Cohen-Kfir, Michael Rosenberg, Reuven Wiener, Shoshana Ravid
Publikováno v:
Journal of Cell Science. 132
An acto-myosin contractile ring, which forms after anaphase onset and is highly regulated in time and space, mediates cytokinesis, the final step of mitosis. The chromosomal passenger complex (CPC), composed of Aurora-B kinase, INCENP, borealin and s
Autor:
Ashutosh Agrawal, Tanmay P. Lele
Publikováno v:
J Cell Sci
Cellular nuclei are bound by two uniformly separated lipid membranes that are fused with each other at numerous donut-shaped pores. These membranes are structurally supported by an array of distinct proteins with distinct mechanical functions. As a r
Publikováno v:
Journal of Cell Science
Growth factor-induced signal transduction pathways are tightly regulated at multiple points intracellularly, but how cells monitor levels of extracellular ligand and translate this information into appropriate downstream responses remains unclear. Un
Publikováno v:
Journal of Cell Science. 132
The essential function of the T cell receptor (TCR) is to translate the engagement of peptides on the major histocompatibility complex (pMHC) into appropriate intracellular signals through the associated cluster of differentiation 3 (CD3) complex. Th